High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
DOI: | 10.1590/1678-77572016-0313 |
Texto Completo: | http://dx.doi.org/10.1590/1678-77572016-0313 http://hdl.handle.net/11449/162479 |
Resumo: | The role of human papillomavirus (HPV) in oral carcinogenesis is still controversial as detection rates of the virus in oral cavity reported in the literature varies greatly. Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Genotyping was performed by multiplex PCR. Results: Benign, premalignant and malignant lesions were diagnosed by histopathology. HPV was detected in 17 samples. Of these, HPV-6 was detected in 10 samples, HPV-18 in four and HPV-16 in one sample. When samples were categorized by lesion types, HPV was detected in two papilloma cases (2/3), five carcinomas (5/6), one hyperplasia (1/1) and nine dysplasia cases (9/11). Conclusion: Unlike other studies in the literature, we reported high occurrence of HPV in oral lesions. Further studies are required to enhance the comprehension of natural history of oral lesions. |
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High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern BrazilPapilomaviridaeMouth mucosaEpidemiologyBrazilThe role of human papillomavirus (HPV) in oral carcinogenesis is still controversial as detection rates of the virus in oral cavity reported in the literature varies greatly. Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Genotyping was performed by multiplex PCR. Results: Benign, premalignant and malignant lesions were diagnosed by histopathology. HPV was detected in 17 samples. Of these, HPV-6 was detected in 10 samples, HPV-18 in four and HPV-16 in one sample. When samples were categorized by lesion types, HPV was detected in two papilloma cases (2/3), five carcinomas (5/6), one hyperplasia (1/1) and nine dysplasia cases (9/11). Conclusion: Unlike other studies in the literature, we reported high occurrence of HPV in oral lesions. Further studies are required to enhance the comprehension of natural history of oral lesions.FAPITEC/SE - Fundacao de Apoio a Pesquisa e Inovacao Tecnilogica do Estado do SergipeUniv Fed Sergipe, Dept Morfol, Lab Entomol & Parasitol Trop, Sao Cristovao, SE, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Patol, Botucatu, SE, BrazilUniv Fed Sergipe, Dept Odontol, Aracaju, SE, BrazilUniv Fed Sergipe, Dept Med, Aracaju, SE, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Patol, Botucatu, SE, BrazilFAPITEC/SE - Fundacao de Apoio a Pesquisa e Inovacao Tecnilogica do Estado do Sergipe: MS/CNPq/ FAPITEC/SE/SES 02/2013 - PPSUS SergipeUniv Sao Paulo Fac Odontologia BauruUniversidade Federal de Sergipe (UFS)Universidade Estadual Paulista (Unesp)Melo Ribeiro, Mariana GoveiaMarcolino, Larissa Doddi [UNESP]Andrade Ramos, Bruna Ribeiro de [UNESP]Miranda, Elaine AlvesTrento, Cleverson Luciano [UNESP]Jain, SonaGurgel, Ricardo QueirozSilva, Marcia Guimaraes da [UNESP]Dolabella, Silvio Santana2018-11-26T17:18:29Z2018-11-26T17:18:29Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article69-74application/pdfhttp://dx.doi.org/10.1590/1678-77572016-0313Journal Of Applied Oral Science. Bauru-sp: Univ Sao Paulo Fac Odontologia Bauru, v. 25, n. 1, p. 69-74, 2017.1678-7757http://hdl.handle.net/11449/16247910.1590/1678-77572016-0313S1678-77572017000100069WOS:000394165400010S1678-77572017000100069.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Applied Oral Science0,645info:eu-repo/semantics/openAccess2024-09-03T13:15:15Zoai:repositorio.unesp.br:11449/162479Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil |
title |
High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil |
spellingShingle |
High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil Melo Ribeiro, Mariana Goveia Papilomaviridae Mouth mucosa Epidemiology Brazil Melo Ribeiro, Mariana Goveia Papilomaviridae Mouth mucosa Epidemiology Brazil |
title_short |
High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil |
title_full |
High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil |
title_fullStr |
High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil |
title_full_unstemmed |
High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil |
title_sort |
High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil |
author |
Melo Ribeiro, Mariana Goveia |
author_facet |
Melo Ribeiro, Mariana Goveia Melo Ribeiro, Mariana Goveia Marcolino, Larissa Doddi [UNESP] Andrade Ramos, Bruna Ribeiro de [UNESP] Miranda, Elaine Alves Trento, Cleverson Luciano [UNESP] Jain, Sona Gurgel, Ricardo Queiroz Silva, Marcia Guimaraes da [UNESP] Dolabella, Silvio Santana Marcolino, Larissa Doddi [UNESP] Andrade Ramos, Bruna Ribeiro de [UNESP] Miranda, Elaine Alves Trento, Cleverson Luciano [UNESP] Jain, Sona Gurgel, Ricardo Queiroz Silva, Marcia Guimaraes da [UNESP] Dolabella, Silvio Santana |
author_role |
author |
author2 |
Marcolino, Larissa Doddi [UNESP] Andrade Ramos, Bruna Ribeiro de [UNESP] Miranda, Elaine Alves Trento, Cleverson Luciano [UNESP] Jain, Sona Gurgel, Ricardo Queiroz Silva, Marcia Guimaraes da [UNESP] Dolabella, Silvio Santana |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Sergipe (UFS) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Melo Ribeiro, Mariana Goveia Marcolino, Larissa Doddi [UNESP] Andrade Ramos, Bruna Ribeiro de [UNESP] Miranda, Elaine Alves Trento, Cleverson Luciano [UNESP] Jain, Sona Gurgel, Ricardo Queiroz Silva, Marcia Guimaraes da [UNESP] Dolabella, Silvio Santana |
dc.subject.por.fl_str_mv |
Papilomaviridae Mouth mucosa Epidemiology Brazil |
topic |
Papilomaviridae Mouth mucosa Epidemiology Brazil |
description |
The role of human papillomavirus (HPV) in oral carcinogenesis is still controversial as detection rates of the virus in oral cavity reported in the literature varies greatly. Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Genotyping was performed by multiplex PCR. Results: Benign, premalignant and malignant lesions were diagnosed by histopathology. HPV was detected in 17 samples. Of these, HPV-6 was detected in 10 samples, HPV-18 in four and HPV-16 in one sample. When samples were categorized by lesion types, HPV was detected in two papilloma cases (2/3), five carcinomas (5/6), one hyperplasia (1/1) and nine dysplasia cases (9/11). Conclusion: Unlike other studies in the literature, we reported high occurrence of HPV in oral lesions. Further studies are required to enhance the comprehension of natural history of oral lesions. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-11-26T17:18:29Z 2018-11-26T17:18:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-77572016-0313 Journal Of Applied Oral Science. Bauru-sp: Univ Sao Paulo Fac Odontologia Bauru, v. 25, n. 1, p. 69-74, 2017. 1678-7757 http://hdl.handle.net/11449/162479 10.1590/1678-77572016-0313 S1678-77572017000100069 WOS:000394165400010 S1678-77572017000100069.pdf |
url |
http://dx.doi.org/10.1590/1678-77572016-0313 http://hdl.handle.net/11449/162479 |
identifier_str_mv |
Journal Of Applied Oral Science. Bauru-sp: Univ Sao Paulo Fac Odontologia Bauru, v. 25, n. 1, p. 69-74, 2017. 1678-7757 10.1590/1678-77572016-0313 S1678-77572017000100069 WOS:000394165400010 S1678-77572017000100069.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Applied Oral Science 0,645 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
69-74 application/pdf |
dc.publisher.none.fl_str_mv |
Univ Sao Paulo Fac Odontologia Bauru |
publisher.none.fl_str_mv |
Univ Sao Paulo Fac Odontologia Bauru |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1822179118388609024 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1678-77572016-0313 |