Potencial cognitivo P300 em indivíduos com diabetes mellitus

• Autor(a) principal: De Freitas Alvarenga, Kátia
• Data de Publicação: 2005
• Outros Autores: Duarte, Josilene Luciene, Camargo Da Silva, Daniela Polo [UNESP], Agostinho-Pesse, Raquel Sampaio [UNESP], Negrato, Carlos Antonio [UNESP], Alves Costa, Orozimbo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S0034-72992005000200014; http://hdl.handle.net/11449/68151
• topic: Audiometry; Diabetes mellitus; Event-related potentials; Hearing loss; P300; glucose; adolescent; adult; aged; auditory cortex; brain cortex; clinical article; cognition; cohort analysis; controlled study; correlation analysis; cranial nerve; diabetes mellitus; diagnostic value; ear; early diagnosis; event related potential; evoked response; eye; female; glucose blood level; human; insulin dependent diabetes mellitus; kidney; male; neurologic disease; peripheral nerve; pure tone audiometry; school child; sensitivity analysis; statistical significance; child; cognitive defect; cross-sectional study; diabetic neuropathy; hearing loss; middle aged; pathophysiology; physiology; Adolescent; Adult; Aged; Auditory Cortex; Child; Cognition; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Diabetic Neuropathies; Event-Related Potentials, P300; Female; Hearing Loss; Humans; Male; Middle Aged

Diabetes Mellitus may lead to alterations in the eyes, kidneys, cranial nerves, peripheral nerves, ears etc. The cognitive function, also, seems to be compromised in subjects presented with Diabetes Mellitus, since the cortical and subcortical structures responsible for this function are hindered in some insulin-dependent patients. The cognitive potential P300 has been used as an objective procedure to assess cerebral cognitive functions. Objective: Analyze the sensitivity of P300 cognitive potential for the detection of alterations on the auditory cortex secondary to Diabetes Mellitus. Study design: transversal cohort. Material and Method: Sixteen diabetic subjects of both genders aged 7 to 71 years, and seventeen non-diabetic individuals at the same age range participated in this study, the evaluation procedures were pure tone audiometry (PTA) and P300 cognitive potential. Glycemia of the group presented with Diabetes was assessed prior to applying the P300. Results: No statistically significant difference was shown for the PTA results. A statically significant difference was observed between groups when analyzing the latency of the P300 component measured in Fz. there was a correlation between glycemia and the latency and amplitude of P300. Conclusion: The investigation of the cognitive potential of P300 is an important procedure for the prevention and early diagnosis of neurological changes in individuals presented with Diabetes Mellitus.