Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)

Detalhes bibliográficos
Autor(a) principal: Sanzovo, T. O.R. [UNESP]
Data de Publicação: 2019
Outros Autores: Lima, N. M. [UNESP], Marqui, S. R. [UNESP], Andrade, T. J.A.S., Navegante, G. [UNESP], Serafim, R. B. [UNESP], Sorbo, J. M. [UNESP], Valente, V. [UNESP], Silva, D. H.S. [UNESP], Soares, C. P. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/14786419.2019.1682574
http://hdl.handle.net/11449/199639
Resumo: This study aimed to identify and evaluate the cytotoxicity, genotoxicity, antigenotoxicity and chemoprevention assessment of flavonoids myricetin-3-O-(2″-O-galloyl)-α-rhamnopyranoside and myricetin-3-rhamnoside from Inga laurina leaves extract. The Quinone reductase induction as a biomarker for cancer chemoprevention was evaluated in murine hepatocellular carcinoma, the cytotoxicity was evaluated by sulforhonamide B assay and genotoxicity was evaluated by comet assay using HepG2 cell line. The results demonstrated that the flavonoids didn´t show cytotoxicity in HepG2 cells. In the chemoprevention evaluations were not able to promote the induction of Quinone Reductase and also no genotoxic effect was observed by evaluation of the comet assay in none of the concentrations tested. In the antigenotoxicity test, all compounds had a protective effect against damage induced by hydrogen peroxide and were repaired against damage. Although none of the flavonoids were capable of inducing the enzyme Quinone Reductase at the concentrations tested, the antigenotoxicity results showed a powerful chemoprotective action.
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spelling Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)chemopreventioncytotoxicityFlavonoidsgenotoxicityInga laurinaThis study aimed to identify and evaluate the cytotoxicity, genotoxicity, antigenotoxicity and chemoprevention assessment of flavonoids myricetin-3-O-(2″-O-galloyl)-α-rhamnopyranoside and myricetin-3-rhamnoside from Inga laurina leaves extract. The Quinone reductase induction as a biomarker for cancer chemoprevention was evaluated in murine hepatocellular carcinoma, the cytotoxicity was evaluated by sulforhonamide B assay and genotoxicity was evaluated by comet assay using HepG2 cell line. The results demonstrated that the flavonoids didn´t show cytotoxicity in HepG2 cells. In the chemoprevention evaluations were not able to promote the induction of Quinone Reductase and also no genotoxic effect was observed by evaluation of the comet assay in none of the concentrations tested. In the antigenotoxicity test, all compounds had a protective effect against damage induced by hydrogen peroxide and were repaired against damage. Although none of the flavonoids were capable of inducing the enzyme Quinone Reductase at the concentrations tested, the antigenotoxicity results showed a powerful chemoprotective action.School of Pharmaceutical Sciences Department of Clinical Analysis São Paulo State University UNESPInstitute of Chemistry Nucleus Bioassays Biosynthesis & Ecophysiology of Natural Products São Paulo State University UNESPNIAC-Nucleus of Research Applied to Sciences-IFMA-Federal Institute of Education Science and Technology of MaranhãoSchool of Pharmaceutical Sciences Department of Clinical Analysis São Paulo State University UNESPInstitute of Chemistry Nucleus Bioassays Biosynthesis & Ecophysiology of Natural Products São Paulo State University UNESPUniversidade Estadual Paulista (Unesp)Science and Technology of MaranhãoSanzovo, T. O.R. [UNESP]Lima, N. M. [UNESP]Marqui, S. R. [UNESP]Andrade, T. J.A.S.Navegante, G. [UNESP]Serafim, R. B. [UNESP]Sorbo, J. M. [UNESP]Valente, V. [UNESP]Silva, D. H.S. [UNESP]Soares, C. P. [UNESP]2020-12-12T01:45:22Z2020-12-12T01:45:22Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/14786419.2019.1682574Natural Product Research.1478-64271478-6419http://hdl.handle.net/11449/19963910.1080/14786419.2019.16825742-s2.0-85074826014Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Researchinfo:eu-repo/semantics/openAccess2024-06-21T15:18:35Zoai:repositorio.unesp.br:11449/199639Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:26:10.241655Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
title Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
spellingShingle Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
Sanzovo, T. O.R. [UNESP]
chemoprevention
cytotoxicity
Flavonoids
genotoxicity
Inga laurina
title_short Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
title_full Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
title_fullStr Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
title_full_unstemmed Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
title_sort Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
author Sanzovo, T. O.R. [UNESP]
author_facet Sanzovo, T. O.R. [UNESP]
Lima, N. M. [UNESP]
Marqui, S. R. [UNESP]
Andrade, T. J.A.S.
Navegante, G. [UNESP]
Serafim, R. B. [UNESP]
Sorbo, J. M. [UNESP]
Valente, V. [UNESP]
Silva, D. H.S. [UNESP]
Soares, C. P. [UNESP]
author_role author
author2 Lima, N. M. [UNESP]
Marqui, S. R. [UNESP]
Andrade, T. J.A.S.
Navegante, G. [UNESP]
Serafim, R. B. [UNESP]
Sorbo, J. M. [UNESP]
Valente, V. [UNESP]
Silva, D. H.S. [UNESP]
Soares, C. P. [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Science and Technology of Maranhão
dc.contributor.author.fl_str_mv Sanzovo, T. O.R. [UNESP]
Lima, N. M. [UNESP]
Marqui, S. R. [UNESP]
Andrade, T. J.A.S.
Navegante, G. [UNESP]
Serafim, R. B. [UNESP]
Sorbo, J. M. [UNESP]
Valente, V. [UNESP]
Silva, D. H.S. [UNESP]
Soares, C. P. [UNESP]
dc.subject.por.fl_str_mv chemoprevention
cytotoxicity
Flavonoids
genotoxicity
Inga laurina
topic chemoprevention
cytotoxicity
Flavonoids
genotoxicity
Inga laurina
description This study aimed to identify and evaluate the cytotoxicity, genotoxicity, antigenotoxicity and chemoprevention assessment of flavonoids myricetin-3-O-(2″-O-galloyl)-α-rhamnopyranoside and myricetin-3-rhamnoside from Inga laurina leaves extract. The Quinone reductase induction as a biomarker for cancer chemoprevention was evaluated in murine hepatocellular carcinoma, the cytotoxicity was evaluated by sulforhonamide B assay and genotoxicity was evaluated by comet assay using HepG2 cell line. The results demonstrated that the flavonoids didn´t show cytotoxicity in HepG2 cells. In the chemoprevention evaluations were not able to promote the induction of Quinone Reductase and also no genotoxic effect was observed by evaluation of the comet assay in none of the concentrations tested. In the antigenotoxicity test, all compounds had a protective effect against damage induced by hydrogen peroxide and were repaired against damage. Although none of the flavonoids were capable of inducing the enzyme Quinone Reductase at the concentrations tested, the antigenotoxicity results showed a powerful chemoprotective action.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
2020-12-12T01:45:22Z
2020-12-12T01:45:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/14786419.2019.1682574
Natural Product Research.
1478-6427
1478-6419
http://hdl.handle.net/11449/199639
10.1080/14786419.2019.1682574
2-s2.0-85074826014
url http://dx.doi.org/10.1080/14786419.2019.1682574
http://hdl.handle.net/11449/199639
identifier_str_mv Natural Product Research.
1478-6427
1478-6419
10.1080/14786419.2019.1682574
2-s2.0-85074826014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Natural Product Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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