Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/14786419.2019.1682574 http://hdl.handle.net/11449/199639 |
Resumo: | This study aimed to identify and evaluate the cytotoxicity, genotoxicity, antigenotoxicity and chemoprevention assessment of flavonoids myricetin-3-O-(2″-O-galloyl)-α-rhamnopyranoside and myricetin-3-rhamnoside from Inga laurina leaves extract. The Quinone reductase induction as a biomarker for cancer chemoprevention was evaluated in murine hepatocellular carcinoma, the cytotoxicity was evaluated by sulforhonamide B assay and genotoxicity was evaluated by comet assay using HepG2 cell line. The results demonstrated that the flavonoids didn´t show cytotoxicity in HepG2 cells. In the chemoprevention evaluations were not able to promote the induction of Quinone Reductase and also no genotoxic effect was observed by evaluation of the comet assay in none of the concentrations tested. In the antigenotoxicity test, all compounds had a protective effect against damage induced by hydrogen peroxide and were repaired against damage. Although none of the flavonoids were capable of inducing the enzyme Quinone Reductase at the concentrations tested, the antigenotoxicity results showed a powerful chemoprotective action. |
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Repositório Institucional da UNESP |
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Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)chemopreventioncytotoxicityFlavonoidsgenotoxicityInga laurinaThis study aimed to identify and evaluate the cytotoxicity, genotoxicity, antigenotoxicity and chemoprevention assessment of flavonoids myricetin-3-O-(2″-O-galloyl)-α-rhamnopyranoside and myricetin-3-rhamnoside from Inga laurina leaves extract. The Quinone reductase induction as a biomarker for cancer chemoprevention was evaluated in murine hepatocellular carcinoma, the cytotoxicity was evaluated by sulforhonamide B assay and genotoxicity was evaluated by comet assay using HepG2 cell line. The results demonstrated that the flavonoids didn´t show cytotoxicity in HepG2 cells. In the chemoprevention evaluations were not able to promote the induction of Quinone Reductase and also no genotoxic effect was observed by evaluation of the comet assay in none of the concentrations tested. In the antigenotoxicity test, all compounds had a protective effect against damage induced by hydrogen peroxide and were repaired against damage. Although none of the flavonoids were capable of inducing the enzyme Quinone Reductase at the concentrations tested, the antigenotoxicity results showed a powerful chemoprotective action.School of Pharmaceutical Sciences Department of Clinical Analysis São Paulo State University UNESPInstitute of Chemistry Nucleus Bioassays Biosynthesis & Ecophysiology of Natural Products São Paulo State University UNESPNIAC-Nucleus of Research Applied to Sciences-IFMA-Federal Institute of Education Science and Technology of MaranhãoSchool of Pharmaceutical Sciences Department of Clinical Analysis São Paulo State University UNESPInstitute of Chemistry Nucleus Bioassays Biosynthesis & Ecophysiology of Natural Products São Paulo State University UNESPUniversidade Estadual Paulista (Unesp)Science and Technology of MaranhãoSanzovo, T. O.R. [UNESP]Lima, N. M. [UNESP]Marqui, S. R. [UNESP]Andrade, T. J.A.S.Navegante, G. [UNESP]Serafim, R. B. [UNESP]Sorbo, J. M. [UNESP]Valente, V. [UNESP]Silva, D. H.S. [UNESP]Soares, C. P. [UNESP]2020-12-12T01:45:22Z2020-12-12T01:45:22Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/14786419.2019.1682574Natural Product Research.1478-64271478-6419http://hdl.handle.net/11449/19963910.1080/14786419.2019.16825742-s2.0-85074826014Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Researchinfo:eu-repo/semantics/openAccess2024-06-21T15:18:35Zoai:repositorio.unesp.br:11449/199639Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:26:10.241655Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE) |
title |
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE) |
spellingShingle |
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE) Sanzovo, T. O.R. [UNESP] chemoprevention cytotoxicity Flavonoids genotoxicity Inga laurina |
title_short |
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE) |
title_full |
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE) |
title_fullStr |
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE) |
title_full_unstemmed |
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE) |
title_sort |
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE) |
author |
Sanzovo, T. O.R. [UNESP] |
author_facet |
Sanzovo, T. O.R. [UNESP] Lima, N. M. [UNESP] Marqui, S. R. [UNESP] Andrade, T. J.A.S. Navegante, G. [UNESP] Serafim, R. B. [UNESP] Sorbo, J. M. [UNESP] Valente, V. [UNESP] Silva, D. H.S. [UNESP] Soares, C. P. [UNESP] |
author_role |
author |
author2 |
Lima, N. M. [UNESP] Marqui, S. R. [UNESP] Andrade, T. J.A.S. Navegante, G. [UNESP] Serafim, R. B. [UNESP] Sorbo, J. M. [UNESP] Valente, V. [UNESP] Silva, D. H.S. [UNESP] Soares, C. P. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Science and Technology of Maranhão |
dc.contributor.author.fl_str_mv |
Sanzovo, T. O.R. [UNESP] Lima, N. M. [UNESP] Marqui, S. R. [UNESP] Andrade, T. J.A.S. Navegante, G. [UNESP] Serafim, R. B. [UNESP] Sorbo, J. M. [UNESP] Valente, V. [UNESP] Silva, D. H.S. [UNESP] Soares, C. P. [UNESP] |
dc.subject.por.fl_str_mv |
chemoprevention cytotoxicity Flavonoids genotoxicity Inga laurina |
topic |
chemoprevention cytotoxicity Flavonoids genotoxicity Inga laurina |
description |
This study aimed to identify and evaluate the cytotoxicity, genotoxicity, antigenotoxicity and chemoprevention assessment of flavonoids myricetin-3-O-(2″-O-galloyl)-α-rhamnopyranoside and myricetin-3-rhamnoside from Inga laurina leaves extract. The Quinone reductase induction as a biomarker for cancer chemoprevention was evaluated in murine hepatocellular carcinoma, the cytotoxicity was evaluated by sulforhonamide B assay and genotoxicity was evaluated by comet assay using HepG2 cell line. The results demonstrated that the flavonoids didn´t show cytotoxicity in HepG2 cells. In the chemoprevention evaluations were not able to promote the induction of Quinone Reductase and also no genotoxic effect was observed by evaluation of the comet assay in none of the concentrations tested. In the antigenotoxicity test, all compounds had a protective effect against damage induced by hydrogen peroxide and were repaired against damage. Although none of the flavonoids were capable of inducing the enzyme Quinone Reductase at the concentrations tested, the antigenotoxicity results showed a powerful chemoprotective action. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 2020-12-12T01:45:22Z 2020-12-12T01:45:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/14786419.2019.1682574 Natural Product Research. 1478-6427 1478-6419 http://hdl.handle.net/11449/199639 10.1080/14786419.2019.1682574 2-s2.0-85074826014 |
url |
http://dx.doi.org/10.1080/14786419.2019.1682574 http://hdl.handle.net/11449/199639 |
identifier_str_mv |
Natural Product Research. 1478-6427 1478-6419 10.1080/14786419.2019.1682574 2-s2.0-85074826014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Natural Product Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128651000020992 |