Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon?
Main Author: | |
---|---|
Publication Date: | 2021 |
Other Authors: | , , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1590/S1984-29612021092 http://hdl.handle.net/11449/230214 |
Summary: | Trypanosomiasis, caused by Trypanosoma vivax, is responsible for great economic losses among livestock in Africa and South America. During the life cycle of these parasites, they may present different morphological, metabolic and physiological characteristics depending on the interactions that are encountered at each point of their life cycle. Although T. vivax is frequently reported in the circulation of its mammalian hosts, it has the ability to migrate to the tissues of these individuals. However, this characteristic is poorly understood. In this context, we aimed to investigate the presence of T. vivax and the changes caused in different tissues of experimentally infected goats. Despite the animals were not perfused before tissues collection, using different approaches, we demonstrated its presence in different samples, including in the adipose tissue and skin of infected animals. In addition, a mononuclear inflammatory reaction, mostly characterized by an infiltrate of lymphocytes, plasma cells and macrophages were observed. The results highlight the possibility that, like other trypanosomatids, T. vivax may use these tissues during its life cycle. Future studies aiming to elucidate the length of time for which T. vivax remains active in these sites, and whether it uses these sites as a refuge from trypanocidal drugs, and whether it is capable of recolonizing the blood circulation, are much needed. |
id |
UNSP_88acfd5986a90b4dcb54f7c6d2bbbf9e |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/230214 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon?Trypanosomiasis, caused by Trypanosoma vivax, is responsible for great economic losses among livestock in Africa and South America. During the life cycle of these parasites, they may present different morphological, metabolic and physiological characteristics depending on the interactions that are encountered at each point of their life cycle. Although T. vivax is frequently reported in the circulation of its mammalian hosts, it has the ability to migrate to the tissues of these individuals. However, this characteristic is poorly understood. In this context, we aimed to investigate the presence of T. vivax and the changes caused in different tissues of experimentally infected goats. Despite the animals were not perfused before tissues collection, using different approaches, we demonstrated its presence in different samples, including in the adipose tissue and skin of infected animals. In addition, a mononuclear inflammatory reaction, mostly characterized by an infiltrate of lymphocytes, plasma cells and macrophages were observed. The results highlight the possibility that, like other trypanosomatids, T. vivax may use these tissues during its life cycle. Future studies aiming to elucidate the length of time for which T. vivax remains active in these sites, and whether it uses these sites as a refuge from trypanocidal drugs, and whether it is capable of recolonizing the blood circulation, are much needed.Departamento de Patologia Reprodução e Saúde Única Faculdade de Ciências Agrárias e Veterinárias - FCAV Universidade Estadual Paulista - UNESPDepartamento de Clínica Cirurgia e Reprodução Animal Faculdade de Medicina Veterinária - FMVA Universidade Estadual Paulista - UNESPDepartment of Infection Biology University of LiverpoolDepartment of Biology Hull York Medical School University of York, Wentworth WayDepartamento de Parasitologia Instituto de Ciências Biomédicas - ICB Universidade de São Paulo - USPDepartamento de Patologia Reprodução e Saúde Única Faculdade de Ciências Agrárias e Veterinárias - FCAV Universidade Estadual Paulista - UNESPDepartamento de Clínica Cirurgia e Reprodução Animal Faculdade de Medicina Veterinária - FMVA Universidade Estadual Paulista - UNESPUniversidade Estadual Paulista (UNESP)University of LiverpoolUniversity of YorkUniversidade de São Paulo (USP)Machado, Rosangela Zacarias [UNESP]Castilho Neto, Kayo José Garcia de Almeida [UNESP]Gonçalves, Luiz Ricardo [UNESP]Machado, Gisele Fabrino [UNESP]Luvizotto, Maria Cecília Rui [UNESP]Vasconcelos, Rosemeri de Oliveira [UNESP]Jussiani, Giulia [UNESP]Silva, Thiago Merighi Vieira da [UNESP]Gimenes, Lindsay Unno [UNESP]Jackson, AndrewWright, GavinTeixeira, Marta Maria Geraldes2022-04-29T08:38:35Z2022-04-29T08:38:35Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlee017721http://dx.doi.org/10.1590/S1984-29612021092Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, v. 30, n. 4, p. e017721-, 2021.1984-2961http://hdl.handle.net/11449/23021410.1590/S1984-296120210922-s2.0-85122772289Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinariainfo:eu-repo/semantics/openAccess2022-04-29T08:38:35Zoai:repositorio.unesp.br:11449/230214Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:38:35Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? |
title |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? |
spellingShingle |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? Machado, Rosangela Zacarias [UNESP] |
title_short |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? |
title_full |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? |
title_fullStr |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? |
title_full_unstemmed |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? |
title_sort |
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon? |
author |
Machado, Rosangela Zacarias [UNESP] |
author_facet |
Machado, Rosangela Zacarias [UNESP] Castilho Neto, Kayo José Garcia de Almeida [UNESP] Gonçalves, Luiz Ricardo [UNESP] Machado, Gisele Fabrino [UNESP] Luvizotto, Maria Cecília Rui [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] Jussiani, Giulia [UNESP] Silva, Thiago Merighi Vieira da [UNESP] Gimenes, Lindsay Unno [UNESP] Jackson, Andrew Wright, Gavin Teixeira, Marta Maria Geraldes |
author_role |
author |
author2 |
Castilho Neto, Kayo José Garcia de Almeida [UNESP] Gonçalves, Luiz Ricardo [UNESP] Machado, Gisele Fabrino [UNESP] Luvizotto, Maria Cecília Rui [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] Jussiani, Giulia [UNESP] Silva, Thiago Merighi Vieira da [UNESP] Gimenes, Lindsay Unno [UNESP] Jackson, Andrew Wright, Gavin Teixeira, Marta Maria Geraldes |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) University of Liverpool University of York Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Machado, Rosangela Zacarias [UNESP] Castilho Neto, Kayo José Garcia de Almeida [UNESP] Gonçalves, Luiz Ricardo [UNESP] Machado, Gisele Fabrino [UNESP] Luvizotto, Maria Cecília Rui [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] Jussiani, Giulia [UNESP] Silva, Thiago Merighi Vieira da [UNESP] Gimenes, Lindsay Unno [UNESP] Jackson, Andrew Wright, Gavin Teixeira, Marta Maria Geraldes |
description |
Trypanosomiasis, caused by Trypanosoma vivax, is responsible for great economic losses among livestock in Africa and South America. During the life cycle of these parasites, they may present different morphological, metabolic and physiological characteristics depending on the interactions that are encountered at each point of their life cycle. Although T. vivax is frequently reported in the circulation of its mammalian hosts, it has the ability to migrate to the tissues of these individuals. However, this characteristic is poorly understood. In this context, we aimed to investigate the presence of T. vivax and the changes caused in different tissues of experimentally infected goats. Despite the animals were not perfused before tissues collection, using different approaches, we demonstrated its presence in different samples, including in the adipose tissue and skin of infected animals. In addition, a mononuclear inflammatory reaction, mostly characterized by an infiltrate of lymphocytes, plasma cells and macrophages were observed. The results highlight the possibility that, like other trypanosomatids, T. vivax may use these tissues during its life cycle. Future studies aiming to elucidate the length of time for which T. vivax remains active in these sites, and whether it uses these sites as a refuge from trypanocidal drugs, and whether it is capable of recolonizing the blood circulation, are much needed. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-29T08:38:35Z 2022-04-29T08:38:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1984-29612021092 Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, v. 30, n. 4, p. e017721-, 2021. 1984-2961 http://hdl.handle.net/11449/230214 10.1590/S1984-29612021092 2-s2.0-85122772289 |
url |
http://dx.doi.org/10.1590/S1984-29612021092 http://hdl.handle.net/11449/230214 |
identifier_str_mv |
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, v. 30, n. 4, p. e017721-, 2021. 1984-2961 10.1590/S1984-29612021092 2-s2.0-85122772289 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
e017721 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965614049067008 |