Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2013/795916 http://hdl.handle.net/11449/76293 |
Resumo: | Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions. © 2013 Francielli de Cássia Yukari Nishimura et al. |
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Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activityhypochlorous acidnaringeninquercetinreactive oxygen metaboliteantioxidant activitycontrolled studyflow cytometryhumanhuman cellin vitro studymicrobial activityneutrophilphagocytepriority journalscanning electron microscopyStaphylococcus aureusNaringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions. © 2013 Francielli de Cássia Yukari Nishimura et al.Departamento de Ciências Básicas da Saúde Universidade Estadual de Maringá, Avenida Colombo 5.790, 87020-900 Maringá, PRDepartamento de Química Faculdade de Ciências Universidade Estadual Paulista, Avenida Eng. Luiz Edmundo Carrijo Coube 14-01, 17033-360 Bauru, SPDepartamento de Química Faculdade de Ciências Universidade Estadual Paulista, Avenida Eng. Luiz Edmundo Carrijo Coube 14-01, 17033-360 Bauru, SPUniversidade Estadual de Maringá (UEM)Universidade Estadual Paulista (Unesp)Nishimura, Francielli de Cássia YukariDe Almeida, Ana Carolina [UNESP]Ratti, Bianca AltrãoUeda-Nakamura, TâniaNakamura, Celso VataruXimenes, Valdecir Farias [UNESP]De Oliveira Silva, Sueli2014-05-27T11:30:11Z2014-05-27T11:30:11Z2013-08-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2013/795916Evidence-based Complementary and Alternative Medicine, v. 2013.1741-427X1741-4288http://hdl.handle.net/11449/7629310.1155/2013/795916WOS:0003226380000012-s2.0-848815055512-s2.0-84881505551.pdf4066413997908572Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary and Alternative Medicine2.0640,683info:eu-repo/semantics/openAccess2024-04-29T18:16:59Zoai:repositorio.unesp.br:11449/76293Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:42:22.718103Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity |
title |
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity |
spellingShingle |
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity Nishimura, Francielli de Cássia Yukari hypochlorous acid naringenin quercetin reactive oxygen metabolite antioxidant activity controlled study flow cytometry human human cell in vitro study microbial activity neutrophil phagocyte priority journal scanning electron microscopy Staphylococcus aureus |
title_short |
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity |
title_full |
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity |
title_fullStr |
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity |
title_full_unstemmed |
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity |
title_sort |
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity |
author |
Nishimura, Francielli de Cássia Yukari |
author_facet |
Nishimura, Francielli de Cássia Yukari De Almeida, Ana Carolina [UNESP] Ratti, Bianca Altrão Ueda-Nakamura, Tânia Nakamura, Celso Vataru Ximenes, Valdecir Farias [UNESP] De Oliveira Silva, Sueli |
author_role |
author |
author2 |
De Almeida, Ana Carolina [UNESP] Ratti, Bianca Altrão Ueda-Nakamura, Tânia Nakamura, Celso Vataru Ximenes, Valdecir Farias [UNESP] De Oliveira Silva, Sueli |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Maringá (UEM) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Nishimura, Francielli de Cássia Yukari De Almeida, Ana Carolina [UNESP] Ratti, Bianca Altrão Ueda-Nakamura, Tânia Nakamura, Celso Vataru Ximenes, Valdecir Farias [UNESP] De Oliveira Silva, Sueli |
dc.subject.por.fl_str_mv |
hypochlorous acid naringenin quercetin reactive oxygen metabolite antioxidant activity controlled study flow cytometry human human cell in vitro study microbial activity neutrophil phagocyte priority journal scanning electron microscopy Staphylococcus aureus |
topic |
hypochlorous acid naringenin quercetin reactive oxygen metabolite antioxidant activity controlled study flow cytometry human human cell in vitro study microbial activity neutrophil phagocyte priority journal scanning electron microscopy Staphylococcus aureus |
description |
Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions. © 2013 Francielli de Cássia Yukari Nishimura et al. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-08-20 2014-05-27T11:30:11Z 2014-05-27T11:30:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2013/795916 Evidence-based Complementary and Alternative Medicine, v. 2013. 1741-427X 1741-4288 http://hdl.handle.net/11449/76293 10.1155/2013/795916 WOS:000322638000001 2-s2.0-84881505551 2-s2.0-84881505551.pdf 4066413997908572 |
url |
http://dx.doi.org/10.1155/2013/795916 http://hdl.handle.net/11449/76293 |
identifier_str_mv |
Evidence-based Complementary and Alternative Medicine, v. 2013. 1741-427X 1741-4288 10.1155/2013/795916 WOS:000322638000001 2-s2.0-84881505551 2-s2.0-84881505551.pdf 4066413997908572 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evidence-based Complementary and Alternative Medicine 2.064 0,683 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128847616409600 |