Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/00914037.2016.1157796 http://hdl.handle.net/11449/178046 |
Resumo: | The biocompatibility of ureasil-polyether hybrid materials has been tested for future application as membrane barrier. The authors evaluated ureasil-polyether hybrids membranes with different swollen behaviors: more swellable ureasil-poliethylene oxide (ureasil-PEO) of molecular wheigth 1900g.mol−1 and less swellable ureasil-polypropilene oxide (ureasil-PPO) of molecular wheigth 400g.mol−1. The swollen behavior was monitored by SAXS measurements and in vivo assays using Rattus Norvegicus were used to study their biocompatibility. The results obtained were compared with the same treatment made with collagen commercial membranes. It was observed that for commercial collagen membranes, inflammatory levels declined after seven days. The ureasil-PEO induced a greater influx of inflammatory cells during 30 days which could be associated with the higher degree of swelling. The ureasil-PPO membranes exhibited a smaller level of inflammatory cells and are good candidates for application as biomaterial, considering their low cost, ability to deliver active molecules, and biocompatibility. |
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Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontologyBiocompatibilityMembranesUreasil-polyether hybrid materialsThe biocompatibility of ureasil-polyether hybrid materials has been tested for future application as membrane barrier. The authors evaluated ureasil-polyether hybrids membranes with different swollen behaviors: more swellable ureasil-poliethylene oxide (ureasil-PEO) of molecular wheigth 1900g.mol−1 and less swellable ureasil-polypropilene oxide (ureasil-PPO) of molecular wheigth 400g.mol−1. The swollen behavior was monitored by SAXS measurements and in vivo assays using Rattus Norvegicus were used to study their biocompatibility. The results obtained were compared with the same treatment made with collagen commercial membranes. It was observed that for commercial collagen membranes, inflammatory levels declined after seven days. The ureasil-PEO induced a greater influx of inflammatory cells during 30 days which could be associated with the higher degree of swelling. The ureasil-PPO membranes exhibited a smaller level of inflammatory cells and are good candidates for application as biomaterial, considering their low cost, ability to deliver active molecules, and biocompatibility.Faculdade de Ciências Farmacêuticas UNESP- Univ Estadual PaulistaFaculdade de Odontologia UNESP- Univ Estadual PaulistaInstituto de Química UNESP-Univ Estadual PaulistaFaculdade de Ciências Farmacêuticas UNESP- Univ Estadual PaulistaFaculdade de Odontologia UNESP- Univ Estadual PaulistaInstituto de Química UNESP-Univ Estadual PaulistaUniversidade Estadual Paulista (Unesp)Oshiro Junior, João Augusto [UNESP]Mortari, Gabriel Riquieri [UNESP]de Freitas, Rubens Moreno [UNESP]Marcantonio-Junior, Elcio [UNESP]Lopes, Leandro [UNESP]Spolidorio, Luis Carlos [UNESP]Marcantonio, Rosemary Adriana [UNESP]Chiavacci, Leila Aparecida [UNESP]2018-12-11T17:28:21Z2018-12-11T17:28:21Z2016-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article647-652application/pdfhttp://dx.doi.org/10.1080/00914037.2016.1157796International Journal of Polymeric Materials and Polymeric Biomaterials, v. 65, n. 13, p. 647-652, 2016.1563-535X0091-4037http://hdl.handle.net/11449/17804610.1080/00914037.2016.11577962-s2.0-849714496302-s2.0-84971449630.pdf2640929291808415Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Polymeric Materials and Polymeric Biomaterials0,489info:eu-repo/semantics/openAccess2024-06-24T13:46:00Zoai:repositorio.unesp.br:11449/178046Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:10:32.126945Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology |
title |
Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology |
spellingShingle |
Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology Oshiro Junior, João Augusto [UNESP] Biocompatibility Membranes Ureasil-polyether hybrid materials |
title_short |
Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology |
title_full |
Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology |
title_fullStr |
Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology |
title_full_unstemmed |
Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology |
title_sort |
Assessment of biocompatibility of ureasil-polyether hybrid membranes for future use in implantodontology |
author |
Oshiro Junior, João Augusto [UNESP] |
author_facet |
Oshiro Junior, João Augusto [UNESP] Mortari, Gabriel Riquieri [UNESP] de Freitas, Rubens Moreno [UNESP] Marcantonio-Junior, Elcio [UNESP] Lopes, Leandro [UNESP] Spolidorio, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana [UNESP] Chiavacci, Leila Aparecida [UNESP] |
author_role |
author |
author2 |
Mortari, Gabriel Riquieri [UNESP] de Freitas, Rubens Moreno [UNESP] Marcantonio-Junior, Elcio [UNESP] Lopes, Leandro [UNESP] Spolidorio, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana [UNESP] Chiavacci, Leila Aparecida [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Oshiro Junior, João Augusto [UNESP] Mortari, Gabriel Riquieri [UNESP] de Freitas, Rubens Moreno [UNESP] Marcantonio-Junior, Elcio [UNESP] Lopes, Leandro [UNESP] Spolidorio, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana [UNESP] Chiavacci, Leila Aparecida [UNESP] |
dc.subject.por.fl_str_mv |
Biocompatibility Membranes Ureasil-polyether hybrid materials |
topic |
Biocompatibility Membranes Ureasil-polyether hybrid materials |
description |
The biocompatibility of ureasil-polyether hybrid materials has been tested for future application as membrane barrier. The authors evaluated ureasil-polyether hybrids membranes with different swollen behaviors: more swellable ureasil-poliethylene oxide (ureasil-PEO) of molecular wheigth 1900g.mol−1 and less swellable ureasil-polypropilene oxide (ureasil-PPO) of molecular wheigth 400g.mol−1. The swollen behavior was monitored by SAXS measurements and in vivo assays using Rattus Norvegicus were used to study their biocompatibility. The results obtained were compared with the same treatment made with collagen commercial membranes. It was observed that for commercial collagen membranes, inflammatory levels declined after seven days. The ureasil-PEO induced a greater influx of inflammatory cells during 30 days which could be associated with the higher degree of swelling. The ureasil-PPO membranes exhibited a smaller level of inflammatory cells and are good candidates for application as biomaterial, considering their low cost, ability to deliver active molecules, and biocompatibility. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 2018-12-11T17:28:21Z 2018-12-11T17:28:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/00914037.2016.1157796 International Journal of Polymeric Materials and Polymeric Biomaterials, v. 65, n. 13, p. 647-652, 2016. 1563-535X 0091-4037 http://hdl.handle.net/11449/178046 10.1080/00914037.2016.1157796 2-s2.0-84971449630 2-s2.0-84971449630.pdf 2640929291808415 |
url |
http://dx.doi.org/10.1080/00914037.2016.1157796 http://hdl.handle.net/11449/178046 |
identifier_str_mv |
International Journal of Polymeric Materials and Polymeric Biomaterials, v. 65, n. 13, p. 647-652, 2016. 1563-535X 0091-4037 10.1080/00914037.2016.1157796 2-s2.0-84971449630 2-s2.0-84971449630.pdf 2640929291808415 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Polymeric Materials and Polymeric Biomaterials 0,489 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
647-652 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129168470179840 |