A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.carbpol.2020.117604 http://hdl.handle.net/11449/207114 |
Resumo: | This study demonstrated a drug-delivery system with anionic beta cyclodextrin (β-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium. The drug-delivery capacity of the multilayer system was proven by controlled drug release over 15 days and sustained released over 30 days. Qualitative images confirmed TC retention within the layer-by-layer (LbL) over 30 days of incubation. Antibacterial activity of TC/anionic β-CD released from the LbL was established against Staphylococcus aureus species. Remarkably, [PAA/PLL]10/TC/anionic β-CD antibacterial effect was sustained even after 30 days of incubation. The non-cytotoxic effect of the multilayer system revealed normal human gingival fibroblast growth. It is expected that this novel approach and the chemical concept to improve drug incorporation into the multilayer system will open up possibilities to make the drug release system more applicable to implantable percutaneous devices. |
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A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devicesCoatingCyclodextrinDrug deliveryLayer-By-LayerPercutaneous deviceThis study demonstrated a drug-delivery system with anionic beta cyclodextrin (β-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium. The drug-delivery capacity of the multilayer system was proven by controlled drug release over 15 days and sustained released over 30 days. Qualitative images confirmed TC retention within the layer-by-layer (LbL) over 30 days of incubation. Antibacterial activity of TC/anionic β-CD released from the LbL was established against Staphylococcus aureus species. Remarkably, [PAA/PLL]10/TC/anionic β-CD antibacterial effect was sustained even after 30 days of incubation. The non-cytotoxic effect of the multilayer system revealed normal human gingival fibroblast growth. It is expected that this novel approach and the chemical concept to improve drug incorporation into the multilayer system will open up possibilities to make the drug release system more applicable to implantable percutaneous devices.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Dental Materials and Prosthodontics School of Dentistry at Araraquara São Paulo State University (UNESP), Humaita, 1680 AraraquaraRegenerative Biomaterials Radboudumc, Philips Van Leydenlaan 25Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP)Department of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP), Av. Limeira, 901Department of Tumor Immunology Radboudumc and Radboud Institute for Molecular Life Sciences (RIMLS), Geert Grooteplein Zuid, 28 NijmegenDepartment of Physiology and Pathology School of Dentistry at Araraquara São Paulo State University (UNESP)Department of Dental Materials and Prosthodontics School of Dentistry at Araraquara São Paulo State University (UNESP), Humaita, 1680 AraraquaraDepartment of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP)Department of Physiology and Pathology School of Dentistry at Araraquara São Paulo State University (UNESP)FAPESP: 2015/03567-7FAPESP: 2018/19345-1Universidade Estadual Paulista (Unesp)RadboudumcUniversidade Estadual de Campinas (UNICAMP)Radboudumc and Radboud Institute for Molecular Life Sciences (RIMLS)Verza, Beatriz S. [UNESP]van den Beucken, Jeroen J.J.P.Brandt, João V. [UNESP]Jafelicci Junior, Miguel [UNESP]Barão, Valentim A.R.Piazza, Rodolfo D. [UNESP]Tagit, OyaSpolidorio, Denise M.P. [UNESP]Vergani, Carlos Eduardo [UNESP]de Avila, Erica D. [UNESP]2021-06-25T10:49:10Z2021-06-25T10:49:10Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.carbpol.2020.117604Carbohydrate Polymers, v. 257.0144-8617http://hdl.handle.net/11449/20711410.1016/j.carbpol.2020.1176042-s2.0-85099179527Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCarbohydrate Polymersinfo:eu-repo/semantics/openAccess2021-10-23T15:34:11Zoai:repositorio.unesp.br:11449/207114Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T15:34:11Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices |
title |
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices |
spellingShingle |
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices Verza, Beatriz S. [UNESP] Coating Cyclodextrin Drug delivery Layer-By-Layer Percutaneous device |
title_short |
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices |
title_full |
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices |
title_fullStr |
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices |
title_full_unstemmed |
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices |
title_sort |
A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices |
author |
Verza, Beatriz S. [UNESP] |
author_facet |
Verza, Beatriz S. [UNESP] van den Beucken, Jeroen J.J.P. Brandt, João V. [UNESP] Jafelicci Junior, Miguel [UNESP] Barão, Valentim A.R. Piazza, Rodolfo D. [UNESP] Tagit, Oya Spolidorio, Denise M.P. [UNESP] Vergani, Carlos Eduardo [UNESP] de Avila, Erica D. [UNESP] |
author_role |
author |
author2 |
van den Beucken, Jeroen J.J.P. Brandt, João V. [UNESP] Jafelicci Junior, Miguel [UNESP] Barão, Valentim A.R. Piazza, Rodolfo D. [UNESP] Tagit, Oya Spolidorio, Denise M.P. [UNESP] Vergani, Carlos Eduardo [UNESP] de Avila, Erica D. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Radboudumc Universidade Estadual de Campinas (UNICAMP) Radboudumc and Radboud Institute for Molecular Life Sciences (RIMLS) |
dc.contributor.author.fl_str_mv |
Verza, Beatriz S. [UNESP] van den Beucken, Jeroen J.J.P. Brandt, João V. [UNESP] Jafelicci Junior, Miguel [UNESP] Barão, Valentim A.R. Piazza, Rodolfo D. [UNESP] Tagit, Oya Spolidorio, Denise M.P. [UNESP] Vergani, Carlos Eduardo [UNESP] de Avila, Erica D. [UNESP] |
dc.subject.por.fl_str_mv |
Coating Cyclodextrin Drug delivery Layer-By-Layer Percutaneous device |
topic |
Coating Cyclodextrin Drug delivery Layer-By-Layer Percutaneous device |
description |
This study demonstrated a drug-delivery system with anionic beta cyclodextrin (β-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium. The drug-delivery capacity of the multilayer system was proven by controlled drug release over 15 days and sustained released over 30 days. Qualitative images confirmed TC retention within the layer-by-layer (LbL) over 30 days of incubation. Antibacterial activity of TC/anionic β-CD released from the LbL was established against Staphylococcus aureus species. Remarkably, [PAA/PLL]10/TC/anionic β-CD antibacterial effect was sustained even after 30 days of incubation. The non-cytotoxic effect of the multilayer system revealed normal human gingival fibroblast growth. It is expected that this novel approach and the chemical concept to improve drug incorporation into the multilayer system will open up possibilities to make the drug release system more applicable to implantable percutaneous devices. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:49:10Z 2021-06-25T10:49:10Z 2021-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.carbpol.2020.117604 Carbohydrate Polymers, v. 257. 0144-8617 http://hdl.handle.net/11449/207114 10.1016/j.carbpol.2020.117604 2-s2.0-85099179527 |
url |
http://dx.doi.org/10.1016/j.carbpol.2020.117604 http://hdl.handle.net/11449/207114 |
identifier_str_mv |
Carbohydrate Polymers, v. 257. 0144-8617 10.1016/j.carbpol.2020.117604 2-s2.0-85099179527 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carbohydrate Polymers |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965387469619200 |