Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.36660/abc.20180433 http://hdl.handle.net/11449/231440 |
Resumo: | Background: Cigarette smoking is usually associated with hypertension and may modify vasoconstrictor response. Objective: The present study aimed to analyze and compare the interaction of passive cigarette smoking and hypertension on epinephrine and felypressin blood pressure effects after intravascular injection. Methods: 45-day male Wistar rats had the main left renal artery partially constricted and the right kidney removed (1K1C model). Rats were placed in the chamber for exposition to passive cigarette smoking (10 cigarettes) during 10 min (6 days a week). Hypertensive rats received atenolol (90 mg/kg/day) by gavage for two weeks. Hypotensive and hypertensive response, response duration and heart rate were recorded from direct blood pressure values. The significance level was 5%. Results: Passive cigarette smoking increased maximal hypertensive response to epinephrine in normotensive and 1K1C-atenolol treated rats and to felypressin only in 1K1C-atenolol treated rats; it also reduced epinephrine hypotensive response. Epinephrine increased heart rate in normotensive and hypertensive passive smokers or non-smoker rats. Comparing the two vasoconstrictors, epinephrine showed greater hypertensive response in normotensive smokers, 1K1C-atenolol treated smokers and non-smokers. However, in normotensive-nonsmoker rats, felypressin showed a greater and longer hypertensive effect. Conclusions: Our results suggest that passive cigarette smoking may reduce epinephrine vasodilation and increase hypertensive response when compared to felypressin. Therefore, felypressin may be safe for hypertensive patients to avoid tachycardia and atenolol interaction, but for normotensive and non-smoker patients, epinephrine may be safer than felypressin. |
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Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenololImpacto do tabagismo passivo na resposta pressórica à epinefrina e felipressina em ratos hipertensos 1k1c tratados ou não com atenololAtenololEpinephrineFelypressinHypertensionNicotine/adverse effectsRatsTobacco smoke pollutionTobacco use disorderBackground: Cigarette smoking is usually associated with hypertension and may modify vasoconstrictor response. Objective: The present study aimed to analyze and compare the interaction of passive cigarette smoking and hypertension on epinephrine and felypressin blood pressure effects after intravascular injection. Methods: 45-day male Wistar rats had the main left renal artery partially constricted and the right kidney removed (1K1C model). Rats were placed in the chamber for exposition to passive cigarette smoking (10 cigarettes) during 10 min (6 days a week). Hypertensive rats received atenolol (90 mg/kg/day) by gavage for two weeks. Hypotensive and hypertensive response, response duration and heart rate were recorded from direct blood pressure values. The significance level was 5%. Results: Passive cigarette smoking increased maximal hypertensive response to epinephrine in normotensive and 1K1C-atenolol treated rats and to felypressin only in 1K1C-atenolol treated rats; it also reduced epinephrine hypotensive response. Epinephrine increased heart rate in normotensive and hypertensive passive smokers or non-smoker rats. Comparing the two vasoconstrictors, epinephrine showed greater hypertensive response in normotensive smokers, 1K1C-atenolol treated smokers and non-smokers. However, in normotensive-nonsmoker rats, felypressin showed a greater and longer hypertensive effect. Conclusions: Our results suggest that passive cigarette smoking may reduce epinephrine vasodilation and increase hypertensive response when compared to felypressin. Therefore, felypressin may be safe for hypertensive patients to avoid tachycardia and atenolol interaction, but for normotensive and non-smoker patients, epinephrine may be safer than felypressin.Faculdade de Odontologia de Bauru Universidade de São Paulo-Ciências Biológicas-FarmacologiaPrograma Conjunto de Pós-Graduação em Ciências Fisiológicas-Departamento de Educação Física-Faculdade de Ciências Universidade Estadual de São PauloPrograma Conjunto de Pós-Graduação em Ciências Fisiológicas-Departamento de Educação Física-Faculdade de Ciências Universidade Estadual de São PauloUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Fleury, Camila A.Almeida, Elizandra P. M.Dionisio, Thiago J.Calvo, Adriana M.Oliveira, Gabriela M.Amaral, Sandra L. [UNESP]Santos, Carlos F.Faria, Flávio A. C.2022-04-29T08:45:27Z2022-04-29T08:45:27Z2020-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article295-303http://dx.doi.org/10.36660/abc.20180433Arquivos Brasileiros de Cardiologia, v. 114, n. 2, p. 295-303, 2020.1678-41700066-782Xhttp://hdl.handle.net/11449/23144010.36660/abc.201804332-s2.0-85081533151Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccess2024-06-24T13:07:38Zoai:repositorio.unesp.br:11449/231440Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:15:52.084569Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol Impacto do tabagismo passivo na resposta pressórica à epinefrina e felipressina em ratos hipertensos 1k1c tratados ou não com atenolol |
title |
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol |
spellingShingle |
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol Fleury, Camila A. Atenolol Epinephrine Felypressin Hypertension Nicotine/adverse effects Rats Tobacco smoke pollution Tobacco use disorder |
title_short |
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol |
title_full |
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol |
title_fullStr |
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol |
title_full_unstemmed |
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol |
title_sort |
Passive cigarette smoking impact on blood pressure response to epinephrine and felypressin in 1K1C hypertensive rats treated or not with atenolol |
author |
Fleury, Camila A. |
author_facet |
Fleury, Camila A. Almeida, Elizandra P. M. Dionisio, Thiago J. Calvo, Adriana M. Oliveira, Gabriela M. Amaral, Sandra L. [UNESP] Santos, Carlos F. Faria, Flávio A. C. |
author_role |
author |
author2 |
Almeida, Elizandra P. M. Dionisio, Thiago J. Calvo, Adriana M. Oliveira, Gabriela M. Amaral, Sandra L. [UNESP] Santos, Carlos F. Faria, Flávio A. C. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Fleury, Camila A. Almeida, Elizandra P. M. Dionisio, Thiago J. Calvo, Adriana M. Oliveira, Gabriela M. Amaral, Sandra L. [UNESP] Santos, Carlos F. Faria, Flávio A. C. |
dc.subject.por.fl_str_mv |
Atenolol Epinephrine Felypressin Hypertension Nicotine/adverse effects Rats Tobacco smoke pollution Tobacco use disorder |
topic |
Atenolol Epinephrine Felypressin Hypertension Nicotine/adverse effects Rats Tobacco smoke pollution Tobacco use disorder |
description |
Background: Cigarette smoking is usually associated with hypertension and may modify vasoconstrictor response. Objective: The present study aimed to analyze and compare the interaction of passive cigarette smoking and hypertension on epinephrine and felypressin blood pressure effects after intravascular injection. Methods: 45-day male Wistar rats had the main left renal artery partially constricted and the right kidney removed (1K1C model). Rats were placed in the chamber for exposition to passive cigarette smoking (10 cigarettes) during 10 min (6 days a week). Hypertensive rats received atenolol (90 mg/kg/day) by gavage for two weeks. Hypotensive and hypertensive response, response duration and heart rate were recorded from direct blood pressure values. The significance level was 5%. Results: Passive cigarette smoking increased maximal hypertensive response to epinephrine in normotensive and 1K1C-atenolol treated rats and to felypressin only in 1K1C-atenolol treated rats; it also reduced epinephrine hypotensive response. Epinephrine increased heart rate in normotensive and hypertensive passive smokers or non-smoker rats. Comparing the two vasoconstrictors, epinephrine showed greater hypertensive response in normotensive smokers, 1K1C-atenolol treated smokers and non-smokers. However, in normotensive-nonsmoker rats, felypressin showed a greater and longer hypertensive effect. Conclusions: Our results suggest that passive cigarette smoking may reduce epinephrine vasodilation and increase hypertensive response when compared to felypressin. Therefore, felypressin may be safe for hypertensive patients to avoid tachycardia and atenolol interaction, but for normotensive and non-smoker patients, epinephrine may be safer than felypressin. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02-01 2022-04-29T08:45:27Z 2022-04-29T08:45:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.36660/abc.20180433 Arquivos Brasileiros de Cardiologia, v. 114, n. 2, p. 295-303, 2020. 1678-4170 0066-782X http://hdl.handle.net/11449/231440 10.36660/abc.20180433 2-s2.0-85081533151 |
url |
http://dx.doi.org/10.36660/abc.20180433 http://hdl.handle.net/11449/231440 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia, v. 114, n. 2, p. 295-303, 2020. 1678-4170 0066-782X 10.36660/abc.20180433 2-s2.0-85081533151 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
295-303 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128913352687616 |