Ação do extrato de própolis na Leishmaniose

Detalhes bibliográficos
Autor(a) principal: Oda, Julie Massayo Maeda
Data de Publicação: 2011
Outros Autores: Fujita, Thiago Cezar, Pitz, Amanda de Fáveri, Amarante, Marla Karine, Felipe, Ionice, Saridakis, Halha Ostrensky, Sforcin, José Maurício [UNESP], Watanabe, Maria Angélica Ehara, Costa, Ivete Conchon
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5433/1679-0367.2011v32n1p111
http://hdl.handle.net/11449/141041
Resumo: Leishmaniasis is a public health problem causing morbidity and mortality in over 80 countries and features a parasitic disease with several manifestations. In the New World occur Visceral Leishmaniasis (VL) and American Cutaneous Leishmaniasis (ACL). The ACL is considered a disease polymorphic of skin and mucous membranes, grouped in different clinical forms: cutaneous leishmaniasis in the skin and mucosa and diffuse cutaneous, and the evolution of this disease is closely related to the mechanisms of escape of the protozoan Leishmania from the immune response, allowing the development of the disease and consequently the onset of clinical manifestations known. The World Health Organization recommends the pentavalent antimony as the first choice drugs. However, they usually give unsatisfactory results, requiring the development of new and affordable drugs for its treatment. It has been investigated that use of propolis it is related to exhibit several biological activities such as antibacterial, antifungal, anti-ulcer agents, antiviral, anti-protozoan, anti-inflammatory, hepatoprotective, antioxidant, antitumor, among others. Recent studies have shown that green propolis active macrophages and stimulates lymphocytes B to produce antibodies. It was also reported that propolis shows a potential antileishmanial activity by reducing the diameter of the lesions, avoiding complications of the lesions by bacteria or by improving the immune response against the Leishmania through macrophages activation. The aim of this work was related the main activities leishmanicida using propolis, by searched the electronic literature PubMed and Scielo during the year 2009.
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spelling Ação do extrato de própolis na LeishmaniosePRÓPOLISLeishmaniaLeishmaniasis is a public health problem causing morbidity and mortality in over 80 countries and features a parasitic disease with several manifestations. In the New World occur Visceral Leishmaniasis (VL) and American Cutaneous Leishmaniasis (ACL). The ACL is considered a disease polymorphic of skin and mucous membranes, grouped in different clinical forms: cutaneous leishmaniasis in the skin and mucosa and diffuse cutaneous, and the evolution of this disease is closely related to the mechanisms of escape of the protozoan Leishmania from the immune response, allowing the development of the disease and consequently the onset of clinical manifestations known. The World Health Organization recommends the pentavalent antimony as the first choice drugs. However, they usually give unsatisfactory results, requiring the development of new and affordable drugs for its treatment. It has been investigated that use of propolis it is related to exhibit several biological activities such as antibacterial, antifungal, anti-ulcer agents, antiviral, anti-protozoan, anti-inflammatory, hepatoprotective, antioxidant, antitumor, among others. Recent studies have shown that green propolis active macrophages and stimulates lymphocytes B to produce antibodies. It was also reported that propolis shows a potential antileishmanial activity by reducing the diameter of the lesions, avoiding complications of the lesions by bacteria or by improving the immune response against the Leishmania through macrophages activation. The aim of this work was related the main activities leishmanicida using propolis, by searched the electronic literature PubMed and Scielo during the year 2009.A leishmaniose causa mortalidade e morbidade em mais de 80 países e caracteriza-se como uma doença parasitária com diversas manifestações, por isso constitui um sério problema de saúde pública. No Novo Mundo ocorre a Leishmaniose Visceral (LV) e Leishmaniose Tegumentar Americana (LTA). A LTA é considerada uma enfermidade polimórfica, espectral da pele e das mucosas, agrupada em diferentes formas clínicas: a leishmaniose cutânea, a cutaneomucosa e a cutânea difusa. A Organização Mundial da Saúde recomenda os antimoniais pentavalentes como drogas de primeira escolha no tratamento da leishmaniose. Entretanto, devido aos efeitos indesejados dessas drogas, tem sido proposto o estudo para o desenvolvimento de novos fármacos para seu tratamento. Assim, tem-se investigado o uso da própolis, visto que está relacionada a muitas atividades biológicas, como antibacteriana, antifúngica, antiulcerativa, antiviral, antiprotozoária, antiinflamatória, hepatoprotetora, antioxidante, antitumoral, entre outras. Estudos recentes mostraram que a própolis verde ativa macrófagos e estimula os linfócitos B a produzirem anticorpos. A própolis tem demonstrado potencial atividade leishmanicida, por diminuir o diâmetro das lesões, causar alterações morfológicas nas formas promastigotas ou ainda por melhorar a resposta imunológica frente às Leishmanias, ativando macrófagos.Portanto, o objetivo deste trabalho foi relatar as principais atividades leishmanicidas da própolis, por meio de pesquisa bibliográfica eletrônica no PubMed e Scielo durante o ano de 2009.Programa de Pós-Graduação em Patologia Experimental, Universidade Estadual de Londrina. Londrina - PRDepartamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de LondrinaDepartamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de LondrinaUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Microbiologia e Imunologia, Instituto de Biociências, Botucatu, Instituto de Biociências - UNESP, Distrito de Rubião Jr., CEP 18618970, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Microbiologia e Imunologia, Instituto de Biociências, Botucatu, Instituto de Biociências - UNESP, Distrito de Rubião Jr., CEP 18618970, SP, BrasilUniversidade Estadual de Londrina (UEL)Universidade Estadual Paulista (Unesp)Oda, Julie Massayo MaedaFujita, Thiago CezarPitz, Amanda de FáveriAmarante, Marla KarineFelipe, IoniceSaridakis, Halha OstrenskySforcin, José Maurício [UNESP]Watanabe, Maria Angélica EharaCosta, Ivete Conchon2016-07-07T12:36:35Z2016-07-07T12:36:35Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article111-121application/pdfhttp://dx.doi.org/10.5433/1679-0367.2011v32n1p111Semina. Ciências Biológicas e da Saúde, v. 32, p. 111-121, 2011.1679-0367http://hdl.handle.net/11449/14104110.5433/1679-0367.2011v32n1p111ISSN1679-0367-2011-32-01-111-121.pdfCurrículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporSemina. Ciências Biológicas e da Saúdeinfo:eu-repo/semantics/openAccess2023-12-02T06:11:17Zoai:repositorio.unesp.br:11449/141041Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:16:35.144532Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Ação do extrato de própolis na Leishmaniose
title Ação do extrato de própolis na Leishmaniose
spellingShingle Ação do extrato de própolis na Leishmaniose
Oda, Julie Massayo Maeda
PRÓPOLIS
Leishmania
title_short Ação do extrato de própolis na Leishmaniose
title_full Ação do extrato de própolis na Leishmaniose
title_fullStr Ação do extrato de própolis na Leishmaniose
title_full_unstemmed Ação do extrato de própolis na Leishmaniose
title_sort Ação do extrato de própolis na Leishmaniose
author Oda, Julie Massayo Maeda
author_facet Oda, Julie Massayo Maeda
Fujita, Thiago Cezar
Pitz, Amanda de Fáveri
Amarante, Marla Karine
Felipe, Ionice
Saridakis, Halha Ostrensky
Sforcin, José Maurício [UNESP]
Watanabe, Maria Angélica Ehara
Costa, Ivete Conchon
author_role author
author2 Fujita, Thiago Cezar
Pitz, Amanda de Fáveri
Amarante, Marla Karine
Felipe, Ionice
Saridakis, Halha Ostrensky
Sforcin, José Maurício [UNESP]
Watanabe, Maria Angélica Ehara
Costa, Ivete Conchon
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Londrina (UEL)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Oda, Julie Massayo Maeda
Fujita, Thiago Cezar
Pitz, Amanda de Fáveri
Amarante, Marla Karine
Felipe, Ionice
Saridakis, Halha Ostrensky
Sforcin, José Maurício [UNESP]
Watanabe, Maria Angélica Ehara
Costa, Ivete Conchon
dc.subject.por.fl_str_mv PRÓPOLIS
Leishmania
topic PRÓPOLIS
Leishmania
description Leishmaniasis is a public health problem causing morbidity and mortality in over 80 countries and features a parasitic disease with several manifestations. In the New World occur Visceral Leishmaniasis (VL) and American Cutaneous Leishmaniasis (ACL). The ACL is considered a disease polymorphic of skin and mucous membranes, grouped in different clinical forms: cutaneous leishmaniasis in the skin and mucosa and diffuse cutaneous, and the evolution of this disease is closely related to the mechanisms of escape of the protozoan Leishmania from the immune response, allowing the development of the disease and consequently the onset of clinical manifestations known. The World Health Organization recommends the pentavalent antimony as the first choice drugs. However, they usually give unsatisfactory results, requiring the development of new and affordable drugs for its treatment. It has been investigated that use of propolis it is related to exhibit several biological activities such as antibacterial, antifungal, anti-ulcer agents, antiviral, anti-protozoan, anti-inflammatory, hepatoprotective, antioxidant, antitumor, among others. Recent studies have shown that green propolis active macrophages and stimulates lymphocytes B to produce antibodies. It was also reported that propolis shows a potential antileishmanial activity by reducing the diameter of the lesions, avoiding complications of the lesions by bacteria or by improving the immune response against the Leishmania through macrophages activation. The aim of this work was related the main activities leishmanicida using propolis, by searched the electronic literature PubMed and Scielo during the year 2009.
publishDate 2011
dc.date.none.fl_str_mv 2011
2016-07-07T12:36:35Z
2016-07-07T12:36:35Z
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dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5433/1679-0367.2011v32n1p111
Semina. Ciências Biológicas e da Saúde, v. 32, p. 111-121, 2011.
1679-0367
http://hdl.handle.net/11449/141041
10.5433/1679-0367.2011v32n1p111
ISSN1679-0367-2011-32-01-111-121.pdf
url http://dx.doi.org/10.5433/1679-0367.2011v32n1p111
http://hdl.handle.net/11449/141041
identifier_str_mv Semina. Ciências Biológicas e da Saúde, v. 32, p. 111-121, 2011.
1679-0367
10.5433/1679-0367.2011v32n1p111
ISSN1679-0367-2011-32-01-111-121.pdf
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Semina. Ciências Biológicas e da Saúde
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 111-121
application/pdf
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
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instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
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