Bone structure, strength and microhardness resulting after hindlimb unloading in rats
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://jms.org.br/v26n3-4/04 http://hdl.handle.net/11449/71393 |
Resumo: | Introduction: Bone strength is influenced by a number of different determinants, such as mass, size, geometry and also by the intrinsic material properties of the tissue. Aims: The structure and mechanical properties of the femur were analyzed in aged (14 mo-old) animals submitted to hindlimb unloading (HU) for 21 days. Methods: Twenty Wistar rats were randomly divided into Control and HU groups and the femur was submitted to dual X ray absorptiometry (DXA), DIGORA radiographic density, mechanical compression testing and Knoop microhardness analyse in cortical and cancellous bone. Results: Femurs from HU group presented significantly lower failure load, decreased bone mineral density (BMD)/bone mineral content (BMC) in whole bone; proximal/distal epiphysis and middiaphyseal cortical bone measured by DXA were similar in the two groups; radiographic density from areas in proximal epiphysis was significantly lower in HU group, and microhardness measured at periosteal and endosteal levels were also signifcantly diminished in HU compared with Control group. Conclusion: Disuse induced damage in the trabecular femoral bone architecture with decisive effect on the head and trochanteric fossa, which became weaker. Bone diaphyseal cortical hardness also suffered effect of unloading, probably related to osteocyte/osteoblast activity. |
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Repositório Institucional da UNESP |
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Bone structure, strength and microhardness resulting after hindlimb unloading in ratsBone densitometryBone microhardnessMechanical strengthRat femurIntroduction: Bone strength is influenced by a number of different determinants, such as mass, size, geometry and also by the intrinsic material properties of the tissue. Aims: The structure and mechanical properties of the femur were analyzed in aged (14 mo-old) animals submitted to hindlimb unloading (HU) for 21 days. Methods: Twenty Wistar rats were randomly divided into Control and HU groups and the femur was submitted to dual X ray absorptiometry (DXA), DIGORA radiographic density, mechanical compression testing and Knoop microhardness analyse in cortical and cancellous bone. Results: Femurs from HU group presented significantly lower failure load, decreased bone mineral density (BMD)/bone mineral content (BMC) in whole bone; proximal/distal epiphysis and middiaphyseal cortical bone measured by DXA were similar in the two groups; radiographic density from areas in proximal epiphysis was significantly lower in HU group, and microhardness measured at periosteal and endosteal levels were also signifcantly diminished in HU compared with Control group. Conclusion: Disuse induced damage in the trabecular femoral bone architecture with decisive effect on the head and trochanteric fossa, which became weaker. Bone diaphyseal cortical hardness also suffered effect of unloading, probably related to osteocyte/osteoblast activity.Department of Pathology, Araçatuba Dental School São Paulo State University - UNESP, Rua José Bonifácio, 1193, CEP 16015-050, Araçatuba, SPDepartment of Support, Production and Animal Health Veterinary Medicine Course at Araçatuba São Paulo State University - UNESPDepartment of Basic Sciences Araçatuba Dental School São Paulo State University - UNESPDepartment of Pathology, Araçatuba Dental School São Paulo State University - UNESP, Rua José Bonifácio, 1193, CEP 16015-050, Araçatuba, SPDepartment of Support, Production and Animal Health Veterinary Medicine Course at Araçatuba São Paulo State University - UNESPDepartment of Basic Sciences Araçatuba Dental School São Paulo State University - UNESPUniversidade Estadual Paulista (Unesp)Carvalho, Antonio Augusto Ferreira [UNESP]Louzada, Mário Jefferson Quirino [UNESP]Nakamune, Ana Cláudia de Melo Stevanato [UNESP]2014-05-27T11:24:31Z2014-05-27T11:24:31Z2009-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article145-150http://jms.org.br/v26n3-4/04Brazilian Journal for Morphological Sciences, v. 26, n. 3-4, p. 145-150, 2009.0102-9010http://hdl.handle.net/11449/713932-s2.0-799538507988110154498443749Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal for Morphological Sciencesinfo:eu-repo/semantics/openAccess2024-09-19T18:57:29Zoai:repositorio.unesp.br:11449/71393Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:57:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bone structure, strength and microhardness resulting after hindlimb unloading in rats |
title |
Bone structure, strength and microhardness resulting after hindlimb unloading in rats |
spellingShingle |
Bone structure, strength and microhardness resulting after hindlimb unloading in rats Carvalho, Antonio Augusto Ferreira [UNESP] Bone densitometry Bone microhardness Mechanical strength Rat femur |
title_short |
Bone structure, strength and microhardness resulting after hindlimb unloading in rats |
title_full |
Bone structure, strength and microhardness resulting after hindlimb unloading in rats |
title_fullStr |
Bone structure, strength and microhardness resulting after hindlimb unloading in rats |
title_full_unstemmed |
Bone structure, strength and microhardness resulting after hindlimb unloading in rats |
title_sort |
Bone structure, strength and microhardness resulting after hindlimb unloading in rats |
author |
Carvalho, Antonio Augusto Ferreira [UNESP] |
author_facet |
Carvalho, Antonio Augusto Ferreira [UNESP] Louzada, Mário Jefferson Quirino [UNESP] Nakamune, Ana Cláudia de Melo Stevanato [UNESP] |
author_role |
author |
author2 |
Louzada, Mário Jefferson Quirino [UNESP] Nakamune, Ana Cláudia de Melo Stevanato [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Carvalho, Antonio Augusto Ferreira [UNESP] Louzada, Mário Jefferson Quirino [UNESP] Nakamune, Ana Cláudia de Melo Stevanato [UNESP] |
dc.subject.por.fl_str_mv |
Bone densitometry Bone microhardness Mechanical strength Rat femur |
topic |
Bone densitometry Bone microhardness Mechanical strength Rat femur |
description |
Introduction: Bone strength is influenced by a number of different determinants, such as mass, size, geometry and also by the intrinsic material properties of the tissue. Aims: The structure and mechanical properties of the femur were analyzed in aged (14 mo-old) animals submitted to hindlimb unloading (HU) for 21 days. Methods: Twenty Wistar rats were randomly divided into Control and HU groups and the femur was submitted to dual X ray absorptiometry (DXA), DIGORA radiographic density, mechanical compression testing and Knoop microhardness analyse in cortical and cancellous bone. Results: Femurs from HU group presented significantly lower failure load, decreased bone mineral density (BMD)/bone mineral content (BMC) in whole bone; proximal/distal epiphysis and middiaphyseal cortical bone measured by DXA were similar in the two groups; radiographic density from areas in proximal epiphysis was significantly lower in HU group, and microhardness measured at periosteal and endosteal levels were also signifcantly diminished in HU compared with Control group. Conclusion: Disuse induced damage in the trabecular femoral bone architecture with decisive effect on the head and trochanteric fossa, which became weaker. Bone diaphyseal cortical hardness also suffered effect of unloading, probably related to osteocyte/osteoblast activity. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 2014-05-27T11:24:31Z 2014-05-27T11:24:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://jms.org.br/v26n3-4/04 Brazilian Journal for Morphological Sciences, v. 26, n. 3-4, p. 145-150, 2009. 0102-9010 http://hdl.handle.net/11449/71393 2-s2.0-79953850798 8110154498443749 |
url |
http://jms.org.br/v26n3-4/04 http://hdl.handle.net/11449/71393 |
identifier_str_mv |
Brazilian Journal for Morphological Sciences, v. 26, n. 3-4, p. 145-150, 2009. 0102-9010 2-s2.0-79953850798 8110154498443749 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal for Morphological Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
145-150 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546495756992512 |