Bone structure, strength and microhardness resulting after hindlimb unloading in rats

Detalhes bibliográficos
Autor(a) principal: Carvalho, Antonio Augusto Ferreira [UNESP]
Data de Publicação: 2009
Outros Autores: Louzada, Mário Jefferson Quirino [UNESP], Nakamune, Ana Cláudia de Melo Stevanato [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://jms.org.br/v26n3-4/04
http://hdl.handle.net/11449/71393
Resumo: Introduction: Bone strength is influenced by a number of different determinants, such as mass, size, geometry and also by the intrinsic material properties of the tissue. Aims: The structure and mechanical properties of the femur were analyzed in aged (14 mo-old) animals submitted to hindlimb unloading (HU) for 21 days. Methods: Twenty Wistar rats were randomly divided into Control and HU groups and the femur was submitted to dual X ray absorptiometry (DXA), DIGORA radiographic density, mechanical compression testing and Knoop microhardness analyse in cortical and cancellous bone. Results: Femurs from HU group presented significantly lower failure load, decreased bone mineral density (BMD)/bone mineral content (BMC) in whole bone; proximal/distal epiphysis and middiaphyseal cortical bone measured by DXA were similar in the two groups; radiographic density from areas in proximal epiphysis was significantly lower in HU group, and microhardness measured at periosteal and endosteal levels were also signifcantly diminished in HU compared with Control group. Conclusion: Disuse induced damage in the trabecular femoral bone architecture with decisive effect on the head and trochanteric fossa, which became weaker. Bone diaphyseal cortical hardness also suffered effect of unloading, probably related to osteocyte/osteoblast activity.
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spelling Bone structure, strength and microhardness resulting after hindlimb unloading in ratsBone densitometryBone microhardnessMechanical strengthRat femurIntroduction: Bone strength is influenced by a number of different determinants, such as mass, size, geometry and also by the intrinsic material properties of the tissue. Aims: The structure and mechanical properties of the femur were analyzed in aged (14 mo-old) animals submitted to hindlimb unloading (HU) for 21 days. Methods: Twenty Wistar rats were randomly divided into Control and HU groups and the femur was submitted to dual X ray absorptiometry (DXA), DIGORA radiographic density, mechanical compression testing and Knoop microhardness analyse in cortical and cancellous bone. Results: Femurs from HU group presented significantly lower failure load, decreased bone mineral density (BMD)/bone mineral content (BMC) in whole bone; proximal/distal epiphysis and middiaphyseal cortical bone measured by DXA were similar in the two groups; radiographic density from areas in proximal epiphysis was significantly lower in HU group, and microhardness measured at periosteal and endosteal levels were also signifcantly diminished in HU compared with Control group. Conclusion: Disuse induced damage in the trabecular femoral bone architecture with decisive effect on the head and trochanteric fossa, which became weaker. Bone diaphyseal cortical hardness also suffered effect of unloading, probably related to osteocyte/osteoblast activity.Department of Pathology, Araçatuba Dental School São Paulo State University - UNESP, Rua José Bonifácio, 1193, CEP 16015-050, Araçatuba, SPDepartment of Support, Production and Animal Health Veterinary Medicine Course at Araçatuba São Paulo State University - UNESPDepartment of Basic Sciences Araçatuba Dental School São Paulo State University - UNESPDepartment of Pathology, Araçatuba Dental School São Paulo State University - UNESP, Rua José Bonifácio, 1193, CEP 16015-050, Araçatuba, SPDepartment of Support, Production and Animal Health Veterinary Medicine Course at Araçatuba São Paulo State University - UNESPDepartment of Basic Sciences Araçatuba Dental School São Paulo State University - UNESPUniversidade Estadual Paulista (Unesp)Carvalho, Antonio Augusto Ferreira [UNESP]Louzada, Mário Jefferson Quirino [UNESP]Nakamune, Ana Cláudia de Melo Stevanato [UNESP]2014-05-27T11:24:31Z2014-05-27T11:24:31Z2009-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article145-150http://jms.org.br/v26n3-4/04Brazilian Journal for Morphological Sciences, v. 26, n. 3-4, p. 145-150, 2009.0102-9010http://hdl.handle.net/11449/713932-s2.0-799538507988110154498443749Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal for Morphological Sciencesinfo:eu-repo/semantics/openAccess2024-09-19T18:57:29Zoai:repositorio.unesp.br:11449/71393Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:57:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Bone structure, strength and microhardness resulting after hindlimb unloading in rats
title Bone structure, strength and microhardness resulting after hindlimb unloading in rats
spellingShingle Bone structure, strength and microhardness resulting after hindlimb unloading in rats
Carvalho, Antonio Augusto Ferreira [UNESP]
Bone densitometry
Bone microhardness
Mechanical strength
Rat femur
title_short Bone structure, strength and microhardness resulting after hindlimb unloading in rats
title_full Bone structure, strength and microhardness resulting after hindlimb unloading in rats
title_fullStr Bone structure, strength and microhardness resulting after hindlimb unloading in rats
title_full_unstemmed Bone structure, strength and microhardness resulting after hindlimb unloading in rats
title_sort Bone structure, strength and microhardness resulting after hindlimb unloading in rats
author Carvalho, Antonio Augusto Ferreira [UNESP]
author_facet Carvalho, Antonio Augusto Ferreira [UNESP]
Louzada, Mário Jefferson Quirino [UNESP]
Nakamune, Ana Cláudia de Melo Stevanato [UNESP]
author_role author
author2 Louzada, Mário Jefferson Quirino [UNESP]
Nakamune, Ana Cláudia de Melo Stevanato [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Carvalho, Antonio Augusto Ferreira [UNESP]
Louzada, Mário Jefferson Quirino [UNESP]
Nakamune, Ana Cláudia de Melo Stevanato [UNESP]
dc.subject.por.fl_str_mv Bone densitometry
Bone microhardness
Mechanical strength
Rat femur
topic Bone densitometry
Bone microhardness
Mechanical strength
Rat femur
description Introduction: Bone strength is influenced by a number of different determinants, such as mass, size, geometry and also by the intrinsic material properties of the tissue. Aims: The structure and mechanical properties of the femur were analyzed in aged (14 mo-old) animals submitted to hindlimb unloading (HU) for 21 days. Methods: Twenty Wistar rats were randomly divided into Control and HU groups and the femur was submitted to dual X ray absorptiometry (DXA), DIGORA radiographic density, mechanical compression testing and Knoop microhardness analyse in cortical and cancellous bone. Results: Femurs from HU group presented significantly lower failure load, decreased bone mineral density (BMD)/bone mineral content (BMC) in whole bone; proximal/distal epiphysis and middiaphyseal cortical bone measured by DXA were similar in the two groups; radiographic density from areas in proximal epiphysis was significantly lower in HU group, and microhardness measured at periosteal and endosteal levels were also signifcantly diminished in HU compared with Control group. Conclusion: Disuse induced damage in the trabecular femoral bone architecture with decisive effect on the head and trochanteric fossa, which became weaker. Bone diaphyseal cortical hardness also suffered effect of unloading, probably related to osteocyte/osteoblast activity.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-01
2014-05-27T11:24:31Z
2014-05-27T11:24:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://jms.org.br/v26n3-4/04
Brazilian Journal for Morphological Sciences, v. 26, n. 3-4, p. 145-150, 2009.
0102-9010
http://hdl.handle.net/11449/71393
2-s2.0-79953850798
8110154498443749
url http://jms.org.br/v26n3-4/04
http://hdl.handle.net/11449/71393
identifier_str_mv Brazilian Journal for Morphological Sciences, v. 26, n. 3-4, p. 145-150, 2009.
0102-9010
2-s2.0-79953850798
8110154498443749
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal for Morphological Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 145-150
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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