Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.7324/JAPS.2012.2830 http://hdl.handle.net/11449/73472 |
Resumo: | Flavonoids have been widely incorporated into cosmetic and dermatological formulations, affording benefits such as antioxidant action, improved skin tone and fewer lines and wrinkles. Brazil has a huge biodiversity, with one of the richest flora in the world, and existing studies justify the quest for greater research efforts in this area. The cajazeira (Spondias lutea L.), a plant of the Anacardiaceae family from tropical America, is widely disseminated in Brazil. This plant was chosen because of the presence of flavonoids that exhibit antioxidant activity. The purpose of this research was to develop a stable topical formulation containing Spondias lutea extract with the aim of preventing skin diseases caused by UV radiation. Hydro ethanolic extract of Spondias lutea fruit was prepared and assayed for its the flavonoids content. The antioxidant activity was estimated by DPPH and superoxide assay. The physicochemical stability and skin permeation of the cream containing 8% (w/w) of extract were assessed. The results showed that the S. lutea extract possessed antioxidant activity, and that it is possible to obtain a stable cosmetic containing the extract, which is able to penetrate the skin. Thus, it is possible to use this extract to produce an anti-aging cosmetic. |
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Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeationAntioxidantCutaneous permeationEmulsionQuercetinRutinSpondias luteaFlavonoids have been widely incorporated into cosmetic and dermatological formulations, affording benefits such as antioxidant action, improved skin tone and fewer lines and wrinkles. Brazil has a huge biodiversity, with one of the richest flora in the world, and existing studies justify the quest for greater research efforts in this area. The cajazeira (Spondias lutea L.), a plant of the Anacardiaceae family from tropical America, is widely disseminated in Brazil. This plant was chosen because of the presence of flavonoids that exhibit antioxidant activity. The purpose of this research was to develop a stable topical formulation containing Spondias lutea extract with the aim of preventing skin diseases caused by UV radiation. Hydro ethanolic extract of Spondias lutea fruit was prepared and assayed for its the flavonoids content. The antioxidant activity was estimated by DPPH and superoxide assay. The physicochemical stability and skin permeation of the cream containing 8% (w/w) of extract were assessed. The results showed that the S. lutea extract possessed antioxidant activity, and that it is possible to obtain a stable cosmetic containing the extract, which is able to penetrate the skin. Thus, it is possible to use this extract to produce an anti-aging cosmetic.Faculdade de Ciências Farmacêuticas UNESP Univ Estadual Paulista, AraraquaraDepartamento de Fármacos e Medicamentos Laboratório de Cosmetologia, LaCosAgroParis Tech - MassyiMed (Research Institute for Medicines and Pharmaceutical Sciences) Lisboan University, LisboaFaculdade de Ciências Farmacêuticas UNESP Univ Estadual Paulista, AraraquaraUniversidade Estadual Paulista (Unesp)Laboratório de CosmetologiaAgroParis Tech - MassyLisboan UniversityIsaac, Vera Lucia Borges [UNESP]Chiari, Bruna G. [UNESP]Miglioli, Kamila [UNESP]Moreira, Raquel [UNESP]Oliveira, José Ricardo SoaresSalgado, Hérida [UNESP]Relkin, PerlaCorrea, Marcos Antonio [UNESP]Salgado, AnaRibeiro, Helena M.2014-05-27T11:26:54Z2014-05-27T11:26:54Z2012-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article174-179application/pdfhttp://dx.doi.org/10.7324/JAPS.2012.2830Journal of Applied Pharmaceutical Science, v. 2, n. 8, p. 174-179, 2012.2231-3354http://hdl.handle.net/11449/7347210.7324/JAPS.2012.28302-s2.0-848761327752-s2.0-84876132775.pdf48424625132856063316011688829943Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Pharmaceutical Science0,244info:eu-repo/semantics/openAccess2024-06-24T13:45:50Zoai:repositorio.unesp.br:11449/73472Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:28:39.512963Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation |
title |
Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation |
spellingShingle |
Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation Isaac, Vera Lucia Borges [UNESP] Antioxidant Cutaneous permeation Emulsion Quercetin Rutin Spondias lutea |
title_short |
Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation |
title_full |
Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation |
title_fullStr |
Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation |
title_full_unstemmed |
Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation |
title_sort |
Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation |
author |
Isaac, Vera Lucia Borges [UNESP] |
author_facet |
Isaac, Vera Lucia Borges [UNESP] Chiari, Bruna G. [UNESP] Miglioli, Kamila [UNESP] Moreira, Raquel [UNESP] Oliveira, José Ricardo Soares Salgado, Hérida [UNESP] Relkin, Perla Correa, Marcos Antonio [UNESP] Salgado, Ana Ribeiro, Helena M. |
author_role |
author |
author2 |
Chiari, Bruna G. [UNESP] Miglioli, Kamila [UNESP] Moreira, Raquel [UNESP] Oliveira, José Ricardo Soares Salgado, Hérida [UNESP] Relkin, Perla Correa, Marcos Antonio [UNESP] Salgado, Ana Ribeiro, Helena M. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Laboratório de Cosmetologia AgroParis Tech - Massy Lisboan University |
dc.contributor.author.fl_str_mv |
Isaac, Vera Lucia Borges [UNESP] Chiari, Bruna G. [UNESP] Miglioli, Kamila [UNESP] Moreira, Raquel [UNESP] Oliveira, José Ricardo Soares Salgado, Hérida [UNESP] Relkin, Perla Correa, Marcos Antonio [UNESP] Salgado, Ana Ribeiro, Helena M. |
dc.subject.por.fl_str_mv |
Antioxidant Cutaneous permeation Emulsion Quercetin Rutin Spondias lutea |
topic |
Antioxidant Cutaneous permeation Emulsion Quercetin Rutin Spondias lutea |
description |
Flavonoids have been widely incorporated into cosmetic and dermatological formulations, affording benefits such as antioxidant action, improved skin tone and fewer lines and wrinkles. Brazil has a huge biodiversity, with one of the richest flora in the world, and existing studies justify the quest for greater research efforts in this area. The cajazeira (Spondias lutea L.), a plant of the Anacardiaceae family from tropical America, is widely disseminated in Brazil. This plant was chosen because of the presence of flavonoids that exhibit antioxidant activity. The purpose of this research was to develop a stable topical formulation containing Spondias lutea extract with the aim of preventing skin diseases caused by UV radiation. Hydro ethanolic extract of Spondias lutea fruit was prepared and assayed for its the flavonoids content. The antioxidant activity was estimated by DPPH and superoxide assay. The physicochemical stability and skin permeation of the cream containing 8% (w/w) of extract were assessed. The results showed that the S. lutea extract possessed antioxidant activity, and that it is possible to obtain a stable cosmetic containing the extract, which is able to penetrate the skin. Thus, it is possible to use this extract to produce an anti-aging cosmetic. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-08-01 2014-05-27T11:26:54Z 2014-05-27T11:26:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.7324/JAPS.2012.2830 Journal of Applied Pharmaceutical Science, v. 2, n. 8, p. 174-179, 2012. 2231-3354 http://hdl.handle.net/11449/73472 10.7324/JAPS.2012.2830 2-s2.0-84876132775 2-s2.0-84876132775.pdf 4842462513285606 3316011688829943 |
url |
http://dx.doi.org/10.7324/JAPS.2012.2830 http://hdl.handle.net/11449/73472 |
identifier_str_mv |
Journal of Applied Pharmaceutical Science, v. 2, n. 8, p. 174-179, 2012. 2231-3354 10.7324/JAPS.2012.2830 2-s2.0-84876132775 2-s2.0-84876132775.pdf 4842462513285606 3316011688829943 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Pharmaceutical Science 0,244 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
174-179 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128937278046208 |