Factors affecting successful antituberculosis treatment: a single-center experience
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1806-9282.20221054 http://hdl.handle.net/11449/247206 |
Resumo: | OBJECTIVE: The identification of factors that influence a favorable antituberculosis treatment outcome could be of great use for the promotion of specific health actions to increase the success rate. Thus, the objective of this study was to investigate the factors affecting successful antituberculosis treatment in patients seen at a reference service in the Western region of São Paulo State/Brazil. METHODS: A retrospective study was carried out from 2010 to 2016 based on the data obtained from the Notification Disease Information System of TB patients treated at a reference service in Brazil. The study included patients with treatment outcomes and excluded those from the penitentiary system or with resistant or multidrug-resistant TB. Patients were categorized as having a successful (cured) or unsuccessful (treatment default and death) treatment outcome. The association between TB treatment outcomes and social and clinical factors was analyzed. RESULTS: A total of 356 cases of TB were treated between 2010 and 2016. Among the cases, the majority were cured and the overall treatment success rate was 85.96%, with a range between 80.33% (2010) and 97.65% (2016). After the exclusion of resistant/multidrug-resistant TB, 348 patients were analyzed. In the final logistic regression model analysis, education less than 8 years (OR 1.66; p<0.0001) and people living with human immunodeficiency virus/acquired immunodeficiency syndrome (OR 0.23; p<0.0046) were found to be significantly related to an unfavorable treatment outcome. CONCLUSION: Low education and being a person living with human immunodeficiency virus/acquired immunodeficiency syndrome are vulnerability factors that can affect the successful outcome of antituberculosis treatment. |
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Factors affecting successful antituberculosis treatment: a single-center experienceAntitubercular agentsHIV infectionsSocioeconomic factorsTuberculosisOBJECTIVE: The identification of factors that influence a favorable antituberculosis treatment outcome could be of great use for the promotion of specific health actions to increase the success rate. Thus, the objective of this study was to investigate the factors affecting successful antituberculosis treatment in patients seen at a reference service in the Western region of São Paulo State/Brazil. METHODS: A retrospective study was carried out from 2010 to 2016 based on the data obtained from the Notification Disease Information System of TB patients treated at a reference service in Brazil. The study included patients with treatment outcomes and excluded those from the penitentiary system or with resistant or multidrug-resistant TB. Patients were categorized as having a successful (cured) or unsuccessful (treatment default and death) treatment outcome. The association between TB treatment outcomes and social and clinical factors was analyzed. RESULTS: A total of 356 cases of TB were treated between 2010 and 2016. Among the cases, the majority were cured and the overall treatment success rate was 85.96%, with a range between 80.33% (2010) and 97.65% (2016). After the exclusion of resistant/multidrug-resistant TB, 348 patients were analyzed. In the final logistic regression model analysis, education less than 8 years (OR 1.66; p<0.0001) and people living with human immunodeficiency virus/acquired immunodeficiency syndrome (OR 0.23; p<0.0046) were found to be significantly related to an unfavorable treatment outcome. CONCLUSION: Low education and being a person living with human immunodeficiency virus/acquired immunodeficiency syndrome are vulnerability factors that can affect the successful outcome of antituberculosis treatment.Estratégia Saúde da Família, SPUniversidade Estadual Paulista “Julio de Mesquita Filho”, SPUniversidade do Oeste Paulista, SPSetor de Tisiologia do Ambulatório “Profª Ana Cardoso Maia de Oliveira Lima”, SPUniversidade Estadual Paulista “Julio de Mesquita Filho”, SPEstratégia Saúde da FamíliaUniversidade Estadual Paulista (UNESP)Universidade do Oeste PaulistaSetor de Tisiologia do Ambulatório “Profª Ana Cardoso Maia de Oliveira Lima”Gonçalves, Marcella Cardosode Aguiar, Amanda Aparecida Silva [UNESP]Biadola, Ana PaulaMazaro, Paulo José MascarenhasRodrigues, Marcus Vinícius Pimentado Prado, Rosana LealPeresi-Lordelo, Eliana2023-07-29T13:09:37Z2023-07-29T13:09:37Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/1806-9282.20221054Revista da Associacao Medica Brasileira, v. 69, n. 4, 2023.1806-92820104-4230http://hdl.handle.net/11449/24720610.1590/1806-9282.202210542-s2.0-85152978598Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Associacao Medica Brasileirainfo:eu-repo/semantics/openAccess2023-07-29T13:09:37Zoai:repositorio.unesp.br:11449/247206Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:06:35.618920Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Factors affecting successful antituberculosis treatment: a single-center experience |
title |
Factors affecting successful antituberculosis treatment: a single-center experience |
spellingShingle |
Factors affecting successful antituberculosis treatment: a single-center experience Gonçalves, Marcella Cardoso Antitubercular agents HIV infections Socioeconomic factors Tuberculosis |
title_short |
Factors affecting successful antituberculosis treatment: a single-center experience |
title_full |
Factors affecting successful antituberculosis treatment: a single-center experience |
title_fullStr |
Factors affecting successful antituberculosis treatment: a single-center experience |
title_full_unstemmed |
Factors affecting successful antituberculosis treatment: a single-center experience |
title_sort |
Factors affecting successful antituberculosis treatment: a single-center experience |
author |
Gonçalves, Marcella Cardoso |
author_facet |
Gonçalves, Marcella Cardoso de Aguiar, Amanda Aparecida Silva [UNESP] Biadola, Ana Paula Mazaro, Paulo José Mascarenhas Rodrigues, Marcus Vinícius Pimenta do Prado, Rosana Leal Peresi-Lordelo, Eliana |
author_role |
author |
author2 |
de Aguiar, Amanda Aparecida Silva [UNESP] Biadola, Ana Paula Mazaro, Paulo José Mascarenhas Rodrigues, Marcus Vinícius Pimenta do Prado, Rosana Leal Peresi-Lordelo, Eliana |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Estratégia Saúde da Família Universidade Estadual Paulista (UNESP) Universidade do Oeste Paulista Setor de Tisiologia do Ambulatório “Profª Ana Cardoso Maia de Oliveira Lima” |
dc.contributor.author.fl_str_mv |
Gonçalves, Marcella Cardoso de Aguiar, Amanda Aparecida Silva [UNESP] Biadola, Ana Paula Mazaro, Paulo José Mascarenhas Rodrigues, Marcus Vinícius Pimenta do Prado, Rosana Leal Peresi-Lordelo, Eliana |
dc.subject.por.fl_str_mv |
Antitubercular agents HIV infections Socioeconomic factors Tuberculosis |
topic |
Antitubercular agents HIV infections Socioeconomic factors Tuberculosis |
description |
OBJECTIVE: The identification of factors that influence a favorable antituberculosis treatment outcome could be of great use for the promotion of specific health actions to increase the success rate. Thus, the objective of this study was to investigate the factors affecting successful antituberculosis treatment in patients seen at a reference service in the Western region of São Paulo State/Brazil. METHODS: A retrospective study was carried out from 2010 to 2016 based on the data obtained from the Notification Disease Information System of TB patients treated at a reference service in Brazil. The study included patients with treatment outcomes and excluded those from the penitentiary system or with resistant or multidrug-resistant TB. Patients were categorized as having a successful (cured) or unsuccessful (treatment default and death) treatment outcome. The association between TB treatment outcomes and social and clinical factors was analyzed. RESULTS: A total of 356 cases of TB were treated between 2010 and 2016. Among the cases, the majority were cured and the overall treatment success rate was 85.96%, with a range between 80.33% (2010) and 97.65% (2016). After the exclusion of resistant/multidrug-resistant TB, 348 patients were analyzed. In the final logistic regression model analysis, education less than 8 years (OR 1.66; p<0.0001) and people living with human immunodeficiency virus/acquired immunodeficiency syndrome (OR 0.23; p<0.0046) were found to be significantly related to an unfavorable treatment outcome. CONCLUSION: Low education and being a person living with human immunodeficiency virus/acquired immunodeficiency syndrome are vulnerability factors that can affect the successful outcome of antituberculosis treatment. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:09:37Z 2023-07-29T13:09:37Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1806-9282.20221054 Revista da Associacao Medica Brasileira, v. 69, n. 4, 2023. 1806-9282 0104-4230 http://hdl.handle.net/11449/247206 10.1590/1806-9282.20221054 2-s2.0-85152978598 |
url |
http://dx.doi.org/10.1590/1806-9282.20221054 http://hdl.handle.net/11449/247206 |
identifier_str_mv |
Revista da Associacao Medica Brasileira, v. 69, n. 4, 2023. 1806-9282 0104-4230 10.1590/1806-9282.20221054 2-s2.0-85152978598 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista da Associacao Medica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129393187356672 |