Estudo histológico do comportamento biológico da matriz óssea homógena no processo de osteoindução

• Autor(a) principal: Abate, Stefania de Paula Assunção [UNESP]
• Data de Publicação: 2011
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149383; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-26/000845722.pdf
• topic: Regeneração óssea; Aloenxertos; Transplante homólogo; Bone regeneration

Purpose: The aim of this study was to evaluate the biological behavior of demineralized bone matrix. Materials and Methods: For this we used twenty-seven rats male, seven animals which donated their calvariae. . The bones were taken to the cycle of demineralization, after processing of the calvariae obtained membranes with about 5mm thick, which were stored in a sterile container containing 98% glycerin. After processing of membrane bone were implanted subcutaneously in 20 rats. After 7, 15, 28, 40 days after surgery was performed orthothanasia animals. Then, the locations of the deployments were dissected and removed to contain the implants and surrounding tissues, the pieces obtained were processed in laboratory for the realization of semi serial six micrometers thick, and stained with hematoxylin and eosin for histological analysis. Results and Conclusion: Clinically, in periods 7, 15, 28 and 40 days, the MOD were incorporated into the surrounding tissue, not inflammatory in character, having no macroscopic signs of calcification, with a consistency similar to MOD. The results obtained in this study show that the fibrous capsule was present in all periodsand that the foreign body type inflammatory reaction tended to increase in a period of 7 to 28 days, however, the period of 40 days she was absent. And in neither period was the presence of bone cells. We conclude that the MOD has no osteoinductive capacity