Influência das propriedades de granulados de lactose nas características físicas dos comprimidos

• Autor(a) principal: Cury, Beatriz Stringhetti Ferreira [UNESP]
• Data de Publicação: 2007
• Outros Autores: Bueno, J. H. F. [UNESP], Silva, N. P. [UNESP], Castro, Ana Doris de [UNESP], Gremião, Maria Palmira Daflon [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/349; http://hdl.handle.net/11449/70149
• topic: Granule; Lactose; Particle size; Tablets; lactose; density; mechanical stress; particle size; tablet; tablet compression; tablet property; tablet surface

The compaction behavior of powdered solids used in tablets can be dominated by the physical-chemical properties of the excipients because, frequently, they are present in much larger amounts than the drug in tablet formulation. The aim of this study was to evaluate the influence of the size of lactose granules on the physical characteristics of tablets produced in punches of various diameters, since this relation has not been explored in the literature. Granules were produced in several sizes by wet granulation and compressed in punches of different diameters by applying different forces. Size distribution, apparent density and flow of granules were evaluated, as well as the physical characteristics of the tablets (weight, friability, hardness and disintegration time). The results indicate that in situations where excipient characteristics predominate due to low drug content, as in the 7 mm punch, the selection of granule size is important for the mechanical strength of tablet. On the other hand, with the 9, 11 and 13mm punches, it was possible to produce strong tablet from all sizes of granules.