Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis

Detalhes bibliográficos
Autor(a) principal: de Moura, Nelci A. [UNESP]
Data de Publicação: 2012
Outros Autores: Caetano, Brunno F. R. [UNESP], Sivieri, Katia [UNESP], Urbano, Luis H. [UNESP], Cabello, Cláudio [UNESP], Rodrigues, Maria A. M. [UNESP], Barbisan, Luis F. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.fct.2012.05.006
http://hdl.handle.net/11449/18769
Resumo: Yacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration of fructans with potential for colon cancer prevention. This study investigated the potential beneficial of yacon intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH-initiation, groups were fed basal diet (Cl and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon plus Lactobacillus casei at 2.5 x 10(10) CFU per g diet) for 13 weeks. At week 20, a significant reduction in number and multiplicity of aberrant crypt foci (ACF) and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower in the group fed synbiotic formulation (p < 0.02). A significant reduction in cell proliferation in colonic crypts and tumors and short chain fatty acids (SCFA) caecal contents was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4). Therefore, the findings this study indicate that yacon and yacon plus L casei intake may reduce the development of chemically-induced colon cancer. (C) 2012 Elsevier Ltd. All rights reserved.
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spelling Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesisYacon rootColon carcinogenesisCancer chemopreventionRatYacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration of fructans with potential for colon cancer prevention. This study investigated the potential beneficial of yacon intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH-initiation, groups were fed basal diet (Cl and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon plus Lactobacillus casei at 2.5 x 10(10) CFU per g diet) for 13 weeks. At week 20, a significant reduction in number and multiplicity of aberrant crypt foci (ACF) and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower in the group fed synbiotic formulation (p < 0.02). A significant reduction in cell proliferation in colonic crypts and tumors and short chain fatty acids (SCFA) caecal contents was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4). Therefore, the findings this study indicate that yacon and yacon plus L casei intake may reduce the development of chemically-induced colon cancer. (C) 2012 Elsevier Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNESP São Paulo State Univ, Inst Biosci, Program Postgrad, Gen & Appl Biol Program, BR-18618970 Botucatu, SP, BrazilUNESP São Paulo State Univ, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, BrazilUNESP São Paulo State Univ, Sch Pharmaceut Sci, Dept Food & Nutr, BR-14801902 Araraquara, SP, BrazilUNESP São Paulo State Univ, Sch Agron Sci, CERAT, BR-18610307 Botucatu, SP, BrazilUNESP São Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP, BrazilUNESP São Paulo State Univ, Inst Biosci, Program Postgrad, Gen & Appl Biol Program, BR-18618970 Botucatu, SP, BrazilUNESP São Paulo State Univ, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, BrazilUNESP São Paulo State Univ, Sch Pharmaceut Sci, Dept Food & Nutr, BR-14801902 Araraquara, SP, BrazilUNESP São Paulo State Univ, Sch Agron Sci, CERAT, BR-18610307 Botucatu, SP, BrazilUNESP São Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP, BrazilFAPESP: 09/12239-2FAPESP: 11/01126-2CNPq: 301585/2009-1Pergamon-Elsevier B.V. LtdUniversidade Estadual Paulista (Unesp)de Moura, Nelci A. [UNESP]Caetano, Brunno F. R. [UNESP]Sivieri, Katia [UNESP]Urbano, Luis H. [UNESP]Cabello, Cláudio [UNESP]Rodrigues, Maria A. M. [UNESP]Barbisan, Luis F. [UNESP]2014-05-20T13:52:35Z2014-05-20T13:52:35Z2012-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2902-2910application/pdfhttp://dx.doi.org/10.1016/j.fct.2012.05.006Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 8, p. 2902-2910, 2012.0278-6915http://hdl.handle.net/11449/1876910.1016/j.fct.2012.05.006WOS:000308255800044WOS000308255800044.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood and Chemical Toxicology3.9771,144info:eu-repo/semantics/openAccess2024-06-21T12:47:11Zoai:repositorio.unesp.br:11449/18769Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:59:15.065346Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis
title Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis
spellingShingle Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis
de Moura, Nelci A. [UNESP]
Yacon root
Colon carcinogenesis
Cancer chemoprevention
Rat
title_short Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis
title_full Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis
title_fullStr Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis
title_full_unstemmed Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis
title_sort Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis
author de Moura, Nelci A. [UNESP]
author_facet de Moura, Nelci A. [UNESP]
Caetano, Brunno F. R. [UNESP]
Sivieri, Katia [UNESP]
Urbano, Luis H. [UNESP]
Cabello, Cláudio [UNESP]
Rodrigues, Maria A. M. [UNESP]
Barbisan, Luis F. [UNESP]
author_role author
author2 Caetano, Brunno F. R. [UNESP]
Sivieri, Katia [UNESP]
Urbano, Luis H. [UNESP]
Cabello, Cláudio [UNESP]
Rodrigues, Maria A. M. [UNESP]
Barbisan, Luis F. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Moura, Nelci A. [UNESP]
Caetano, Brunno F. R. [UNESP]
Sivieri, Katia [UNESP]
Urbano, Luis H. [UNESP]
Cabello, Cláudio [UNESP]
Rodrigues, Maria A. M. [UNESP]
Barbisan, Luis F. [UNESP]
dc.subject.por.fl_str_mv Yacon root
Colon carcinogenesis
Cancer chemoprevention
Rat
topic Yacon root
Colon carcinogenesis
Cancer chemoprevention
Rat
description Yacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration of fructans with potential for colon cancer prevention. This study investigated the potential beneficial of yacon intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH-initiation, groups were fed basal diet (Cl and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon plus Lactobacillus casei at 2.5 x 10(10) CFU per g diet) for 13 weeks. At week 20, a significant reduction in number and multiplicity of aberrant crypt foci (ACF) and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower in the group fed synbiotic formulation (p < 0.02). A significant reduction in cell proliferation in colonic crypts and tumors and short chain fatty acids (SCFA) caecal contents was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4). Therefore, the findings this study indicate that yacon and yacon plus L casei intake may reduce the development of chemically-induced colon cancer. (C) 2012 Elsevier Ltd. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-01
2014-05-20T13:52:35Z
2014-05-20T13:52:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.fct.2012.05.006
Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 8, p. 2902-2910, 2012.
0278-6915
http://hdl.handle.net/11449/18769
10.1016/j.fct.2012.05.006
WOS:000308255800044
WOS000308255800044.pdf
url http://dx.doi.org/10.1016/j.fct.2012.05.006
http://hdl.handle.net/11449/18769
identifier_str_mv Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 8, p. 2902-2910, 2012.
0278-6915
10.1016/j.fct.2012.05.006
WOS:000308255800044
WOS000308255800044.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Food and Chemical Toxicology
3.977
1,144
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2902-2910
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier B.V. Ltd
publisher.none.fl_str_mv Pergamon-Elsevier B.V. Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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