Estudo histomorfométrico do processo de cicatrização óssea em defeitos cirúrgicos de camanho crítico em calvárias de ratos preenchidos com polímero de mamona

• Autor(a) principal: Almeida, Juliano Milanezi de [UNESP]
• Data de Publicação: 2010
• Outros Autores: Santos, Murillo Rezende [UNESP], Fernandes, Leandro Araujo [UNESP], Theodoro, Letícia Helena [UNESP], Garcia, Valdir Gouveia [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://apcdaracatuba.com.br/revista/Volume_31_01_Jan_2010/v31n1.htm; http://hdl.handle.net/11449/133138
• topic: Wound healing; Bone regeneration; Castor bean; Materials testing; Cicatrização de feridas; Regeneração óssea; Semente de rícino; Teste de materiais

Objectives: The aim of this study was to evaluate the behavior of the polymer histomorphometrically castor during the healing process of defects of critical size calvarial preparations in rats. Materials and Methods: Twenty animals underwent a surgical procedure that was to be held in the calvaria of each animal a critical defect of 8 mm in diameter with a drill trephine. The rats were divided into two groups according to the following procedures: group C received no treatment and the bone defect site was filled with blood clot, group M, the bone defect was filled with castor oil polymer particles. The animals were sacrificed 180 days after the surgical procedures. After routine laboratory procedures the specimens were subjected to analysis histomorphometric. Results: In groups C the newly formed bone tissue was well developed, with adjacent areas of osteoid matrix rich in osteoblasts, and restricted to the vicinity of the edges of the defect. In animals of group M was observed newly formed lamellar bone tissue restricted to the vicinity of the defect edges and particles of polymer Castor distributed throughout the defect. There was a higher percentage of newly formed bone area was statistically significant in group C compared to animals in group M. Conclusions: Within the limits of this study can conclude that the castor oil polymer is biocompatible and had kept the area during the healing of critical size defects in surgically prepared rat calvariae.