Influence of different durations of estrogen deficiency on alveolar bone loss in rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1806-83242011000600011 http://hdl.handle.net/11449/226820 |
Resumo: | The purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. Sixty female Wistar rats were randomly assigned to ovariectomy (OVX test group) or sham operation (SHAM control group). The OVX and SHAM groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). In all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. The maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. A comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p < 0.05). No significant differences were observed among the unligated groups (p > 0.05). A significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). These results demonstrate that long-term estrogen deficiency affects ligatureinduced alveolar bone loss. |
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Influence of different durations of estrogen deficiency on alveolar bone loss in ratsAlveolar bone lossBone diseasesPeriodontitisThe purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. Sixty female Wistar rats were randomly assigned to ovariectomy (OVX test group) or sham operation (SHAM control group). The OVX and SHAM groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). In all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. The maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. A comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p < 0.05). No significant differences were observed among the unligated groups (p > 0.05). A significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). These results demonstrate that long-term estrogen deficiency affects ligatureinduced alveolar bone loss.Department of Dentistry School of Dentistry of Pindamonhangaba FAPI - Faculty of Pindamonhangaba, Pindamonhangaba, SPDepartment of Bioscience and Oral Diagnosis School of Dentistry of São José dos Campos UNESP - University Estadual Paulista, São José dos Campos, SPDepartment of Bioscience and Oral Diagnosis School of Dentistry of São José dos Campos UNESP - University Estadual Paulista, São José dos Campos, SPFAPI - Faculty of PindamonhangabaUniversidade Estadual Paulista (UNESP)Amadei, Susana Ungarode Souza, Daniela MartinsBrandão, Adriana Aigotti Haberbeck [UNESP]da Rocha, Rosilene Fernandes [UNESP]2022-04-29T02:57:13Z2022-04-29T02:57:13Z2011-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article538-543http://dx.doi.org/10.1590/S1806-83242011000600011Brazilian Oral Research, v. 25, n. 6, p. 538-543, 2011.1806-83241807-3107http://hdl.handle.net/11449/22682010.1590/S1806-832420110006000112-s2.0-84861121866Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Oral Researchinfo:eu-repo/semantics/openAccess2022-04-29T02:57:13Zoai:repositorio.unesp.br:11449/226820Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:56:59.534895Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of different durations of estrogen deficiency on alveolar bone loss in rats |
title |
Influence of different durations of estrogen deficiency on alveolar bone loss in rats |
spellingShingle |
Influence of different durations of estrogen deficiency on alveolar bone loss in rats Amadei, Susana Ungaro Alveolar bone loss Bone diseases Periodontitis |
title_short |
Influence of different durations of estrogen deficiency on alveolar bone loss in rats |
title_full |
Influence of different durations of estrogen deficiency on alveolar bone loss in rats |
title_fullStr |
Influence of different durations of estrogen deficiency on alveolar bone loss in rats |
title_full_unstemmed |
Influence of different durations of estrogen deficiency on alveolar bone loss in rats |
title_sort |
Influence of different durations of estrogen deficiency on alveolar bone loss in rats |
author |
Amadei, Susana Ungaro |
author_facet |
Amadei, Susana Ungaro de Souza, Daniela Martins Brandão, Adriana Aigotti Haberbeck [UNESP] da Rocha, Rosilene Fernandes [UNESP] |
author_role |
author |
author2 |
de Souza, Daniela Martins Brandão, Adriana Aigotti Haberbeck [UNESP] da Rocha, Rosilene Fernandes [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
FAPI - Faculty of Pindamonhangaba Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Amadei, Susana Ungaro de Souza, Daniela Martins Brandão, Adriana Aigotti Haberbeck [UNESP] da Rocha, Rosilene Fernandes [UNESP] |
dc.subject.por.fl_str_mv |
Alveolar bone loss Bone diseases Periodontitis |
topic |
Alveolar bone loss Bone diseases Periodontitis |
description |
The purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. Sixty female Wistar rats were randomly assigned to ovariectomy (OVX test group) or sham operation (SHAM control group). The OVX and SHAM groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). In all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. The maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. A comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p < 0.05). No significant differences were observed among the unligated groups (p > 0.05). A significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). These results demonstrate that long-term estrogen deficiency affects ligatureinduced alveolar bone loss. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-11-01 2022-04-29T02:57:13Z 2022-04-29T02:57:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1806-83242011000600011 Brazilian Oral Research, v. 25, n. 6, p. 538-543, 2011. 1806-8324 1807-3107 http://hdl.handle.net/11449/226820 10.1590/S1806-83242011000600011 2-s2.0-84861121866 |
url |
http://dx.doi.org/10.1590/S1806-83242011000600011 http://hdl.handle.net/11449/226820 |
identifier_str_mv |
Brazilian Oral Research, v. 25, n. 6, p. 538-543, 2011. 1806-8324 1807-3107 10.1590/S1806-83242011000600011 2-s2.0-84861121866 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Oral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
538-543 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129565925572608 |