The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sciencedirect.com/science/article/pii/S0024320514009163 http://hdl.handle.net/11449/128550 |
Resumo: | Aims: The present study aimed to investigate the effects of the interaction between the abusive use of nandrolone decanoate (ND) and physical activity on the prostate structure of adult and older rats. We evaluated whether the use of ND, associated or not with physical exercise during the post-pubertal stage, interferes with the morphophysiology of the prostate.Main methods: Fifty-six male Sprague-Dawley rats were divided into eight groups. The animals were treated for eight weeks and divided into sedentary and trained groups, with or without ND use. Four groups were sacrificed 48 h after the end of the eight week experiment (adult groups), and four other groups were sacrificed at 300 days of age (older groups). The prostate was collected and processed for stereological and histopathological analysis and for the expression of AQP1 and VEGF by the Western blotting technique.Key findings: Both ND and physical activity altered the ventral prostate structure of the rats; the AQP1 and VEGF expression increased in young animals subjected to physical exercise.Significance: Thus, it was concluded that the use of ND, associated or not with exercise during the post-pubertal stage, interferes with the morphophysiology of the prostate. (c) 2014 Elsevier Inc All rights reserved. |
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The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older ratsVentral prostateVEGFAQP1AnabolicResistance physical exerciseAims: The present study aimed to investigate the effects of the interaction between the abusive use of nandrolone decanoate (ND) and physical activity on the prostate structure of adult and older rats. We evaluated whether the use of ND, associated or not with physical exercise during the post-pubertal stage, interferes with the morphophysiology of the prostate.Main methods: Fifty-six male Sprague-Dawley rats were divided into eight groups. The animals were treated for eight weeks and divided into sedentary and trained groups, with or without ND use. Four groups were sacrificed 48 h after the end of the eight week experiment (adult groups), and four other groups were sacrificed at 300 days of age (older groups). The prostate was collected and processed for stereological and histopathological analysis and for the expression of AQP1 and VEGF by the Western blotting technique.Key findings: Both ND and physical activity altered the ventral prostate structure of the rats; the AQP1 and VEGF expression increased in young animals subjected to physical exercise.Significance: Thus, it was concluded that the use of ND, associated or not with exercise during the post-pubertal stage, interferes with the morphophysiology of the prostate. (c) 2014 Elsevier Inc All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fac Med Marilia FAMEMA, Marilia, SP, BrazilUniv Estadual Paulista UNESP, Dept Anat, Inst Biosci, Botucatu, SP, BrazilUniv Estadual Paulista UNESP, Sch Sci, Dept Biol Sci, Bauru, SP, BrazilUniv Estadual Paulista UNESP, Inst Biosci, Dept Morphol, Bauru, SP, BrazilUniv Campinas UNICAMP, Inst Biol, Dept Struct &Funct Biol, Campinas, SP, BrazilUniv Estadual Paulista UNESP, Dept Anat, Inst Biosci, Botucatu, SP, BrazilUniv Estadual Paulista UNESP, Sch Sci, Dept Biol Sci, Bauru, SP, BrazilUniv Estadual Paulista UNESP, Inst Biosci, Dept Morphol, Bauru, SP, BrazilFAPESP: 2013/07203-4Elsevier B.V.Faculdade de Medicina de Marilia (FAMEMA)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Melo Neto, Joao Simao deGomes, Fabiana de Campos [UNESP]Felipe Pinheiro, Patricia Fernanda [UNESP]Pereira, Sergio [UNESP]Scarano, Wellerson Rodrigo [UNESP]Favaro, Wagner JoseDomeniconi, Raquel Fantin [UNESP]2015-10-21T13:10:53Z2015-10-21T13:10:53Z2015-01-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16-21http://www.sciencedirect.com/science/article/pii/S0024320514009163Life Sciences, v. 121, p. 16-21, 2015.0024-3205http://hdl.handle.net/11449/12855010.1016/j.lfs.2014.11.006WOS:000349590800003537415932205824854817565282994690000-0003-0030-81980000-0003-2938-010XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciences3.2341,071info:eu-repo/semantics/openAccess2024-04-23T15:23:49Zoai:repositorio.unesp.br:11449/128550Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-23T15:23:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats |
title |
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats |
spellingShingle |
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats Melo Neto, Joao Simao de Ventral prostate VEGF AQP1 Anabolic Resistance physical exercise |
title_short |
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats |
title_full |
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats |
title_fullStr |
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats |
title_full_unstemmed |
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats |
title_sort |
The effects of high doses of nandrolone decanoate and exercise on prostate microvasculature of adult and older rats |
author |
Melo Neto, Joao Simao de |
author_facet |
Melo Neto, Joao Simao de Gomes, Fabiana de Campos [UNESP] Felipe Pinheiro, Patricia Fernanda [UNESP] Pereira, Sergio [UNESP] Scarano, Wellerson Rodrigo [UNESP] Favaro, Wagner Jose Domeniconi, Raquel Fantin [UNESP] |
author_role |
author |
author2 |
Gomes, Fabiana de Campos [UNESP] Felipe Pinheiro, Patricia Fernanda [UNESP] Pereira, Sergio [UNESP] Scarano, Wellerson Rodrigo [UNESP] Favaro, Wagner Jose Domeniconi, Raquel Fantin [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina de Marilia (FAMEMA) Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Melo Neto, Joao Simao de Gomes, Fabiana de Campos [UNESP] Felipe Pinheiro, Patricia Fernanda [UNESP] Pereira, Sergio [UNESP] Scarano, Wellerson Rodrigo [UNESP] Favaro, Wagner Jose Domeniconi, Raquel Fantin [UNESP] |
dc.subject.por.fl_str_mv |
Ventral prostate VEGF AQP1 Anabolic Resistance physical exercise |
topic |
Ventral prostate VEGF AQP1 Anabolic Resistance physical exercise |
description |
Aims: The present study aimed to investigate the effects of the interaction between the abusive use of nandrolone decanoate (ND) and physical activity on the prostate structure of adult and older rats. We evaluated whether the use of ND, associated or not with physical exercise during the post-pubertal stage, interferes with the morphophysiology of the prostate.Main methods: Fifty-six male Sprague-Dawley rats were divided into eight groups. The animals were treated for eight weeks and divided into sedentary and trained groups, with or without ND use. Four groups were sacrificed 48 h after the end of the eight week experiment (adult groups), and four other groups were sacrificed at 300 days of age (older groups). The prostate was collected and processed for stereological and histopathological analysis and for the expression of AQP1 and VEGF by the Western blotting technique.Key findings: Both ND and physical activity altered the ventral prostate structure of the rats; the AQP1 and VEGF expression increased in young animals subjected to physical exercise.Significance: Thus, it was concluded that the use of ND, associated or not with exercise during the post-pubertal stage, interferes with the morphophysiology of the prostate. (c) 2014 Elsevier Inc All rights reserved. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:10:53Z 2015-10-21T13:10:53Z 2015-01-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sciencedirect.com/science/article/pii/S0024320514009163 Life Sciences, v. 121, p. 16-21, 2015. 0024-3205 http://hdl.handle.net/11449/128550 10.1016/j.lfs.2014.11.006 WOS:000349590800003 5374159322058248 5481756528299469 0000-0003-0030-8198 0000-0003-2938-010X |
url |
http://www.sciencedirect.com/science/article/pii/S0024320514009163 http://hdl.handle.net/11449/128550 |
identifier_str_mv |
Life Sciences, v. 121, p. 16-21, 2015. 0024-3205 10.1016/j.lfs.2014.11.006 WOS:000349590800003 5374159322058248 5481756528299469 0000-0003-0030-8198 0000-0003-2938-010X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life Sciences 3.234 1,071 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16-21 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803047061184053248 |