Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jphotobiol.2020.111877 http://hdl.handle.net/11449/200261 |
Resumo: | Photobiomodulation therapy (PBMT) has many effects on the energy metabolism of musculoskeletal tissue, such as increased glycogen and adenosine triphosphate synthesis. In addition, these effects may be due to a systemic blood glucose control. Twenty-four Wistar rats were randomly and equally allocated into four groups: sham, PBMT 10 J/cm2, PBMT 30 J/cm2 and PBMT 60 J/cm2. The animals were fasting for 6 h for blood glucose evaluations during pre-irradiation period, 1 h, 3 h and 6 h after PBMT. Muscle glycogen synthesis was measured 24 h after PBMT. This PBMT used a cluster of 69 LEDs (light-emitting diodes) with 35 red (630 ± 10 nm) and 34 infrared (850 ± 20 nm); 114 mW/cm2 for 90s (10 J/cm2), 270 s (30 J/cm2), 540 s (60 J/cm2) applied on large muscle areas (back and hind legs) of the animals. The 10 J/cm2 group showed lower blood glucose levels and glucose variability over 6 h (5.92 mg/dL) compared to the sham (13.03 mg/dL), 30 J/cm2 (7.77 mg/dL) and 60 J/cm2 (9.07 mg/dL) groups. The PBMT groups had the greatest increase in muscle glycogen (10 J/cm2 > 60 J/cm2 > 30 J/cm2 > sham), characterizing a triphasic dose-response of PBMT. There was a strong negative correlation between blood glucose variability over 6 h and muscle glycogen concentration for 10 J/cm2 group (r = −0.94; p < .001) followed by 30 J/cm2 group (r = −0.84; p < .001) and 60 J/cm2 group(r = −0.73; p < .006). These results suggest that PBMT can play a very important role in the control of blood glucose levels, and its possible mechanism of action is the induction of greater muscle glycogen synthesis independently of physical exercise. |
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Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?Blood glucoseDiabetes mellitusGlycogenLED therapyLow-level laser therapyPhotobiomodulation therapy (PBMT) has many effects on the energy metabolism of musculoskeletal tissue, such as increased glycogen and adenosine triphosphate synthesis. In addition, these effects may be due to a systemic blood glucose control. Twenty-four Wistar rats were randomly and equally allocated into four groups: sham, PBMT 10 J/cm2, PBMT 30 J/cm2 and PBMT 60 J/cm2. The animals were fasting for 6 h for blood glucose evaluations during pre-irradiation period, 1 h, 3 h and 6 h after PBMT. Muscle glycogen synthesis was measured 24 h after PBMT. This PBMT used a cluster of 69 LEDs (light-emitting diodes) with 35 red (630 ± 10 nm) and 34 infrared (850 ± 20 nm); 114 mW/cm2 for 90s (10 J/cm2), 270 s (30 J/cm2), 540 s (60 J/cm2) applied on large muscle areas (back and hind legs) of the animals. The 10 J/cm2 group showed lower blood glucose levels and glucose variability over 6 h (5.92 mg/dL) compared to the sham (13.03 mg/dL), 30 J/cm2 (7.77 mg/dL) and 60 J/cm2 (9.07 mg/dL) groups. The PBMT groups had the greatest increase in muscle glycogen (10 J/cm2 > 60 J/cm2 > 30 J/cm2 > sham), characterizing a triphasic dose-response of PBMT. There was a strong negative correlation between blood glucose variability over 6 h and muscle glycogen concentration for 10 J/cm2 group (r = −0.94; p < .001) followed by 30 J/cm2 group (r = −0.84; p < .001) and 60 J/cm2 group(r = −0.73; p < .006). These results suggest that PBMT can play a very important role in the control of blood glucose levels, and its possible mechanism of action is the induction of greater muscle glycogen synthesis independently of physical exercise.Post-Graduation Program in Biomedical Engineering Universidade BrasilLaboratory of Physiology and Human Performance São Paulo State University – UNESP, BauruUniversidade do Sagrado Coração (USC) BauruLaboratory of Physiology and Human Performance São Paulo State University – UNESP, BauruUniversidade BrasilUniversidade Estadual Paulista (Unesp)BauruCastro, Kenia Mendes Rodriguesde Paiva Carvalho, Rodrigo Leal [UNESP]Junior, Geraldo Marco RosaTavares, Beatriz AntoniassiSimionato, Luis HenriqueBortoluci, Carlos Henrique FachinSoto, Claudio Alberto TellezFerraresi, Cleber2020-12-12T02:01:54Z2020-12-12T02:01:54Z2020-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jphotobiol.2020.111877Journal of Photochemistry and Photobiology B: Biology, v. 207.1873-26821011-1344http://hdl.handle.net/11449/20026110.1016/j.jphotobiol.2020.1118772-s2.0-85083062940Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Photochemistry and Photobiology B: Biologyinfo:eu-repo/semantics/openAccess2024-04-25T17:39:51Zoai:repositorio.unesp.br:11449/200261Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-25T17:39:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis? |
title |
Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis? |
spellingShingle |
Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis? Castro, Kenia Mendes Rodrigues Blood glucose Diabetes mellitus Glycogen LED therapy Low-level laser therapy |
title_short |
Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis? |
title_full |
Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis? |
title_fullStr |
Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis? |
title_full_unstemmed |
Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis? |
title_sort |
Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis? |
author |
Castro, Kenia Mendes Rodrigues |
author_facet |
Castro, Kenia Mendes Rodrigues de Paiva Carvalho, Rodrigo Leal [UNESP] Junior, Geraldo Marco Rosa Tavares, Beatriz Antoniassi Simionato, Luis Henrique Bortoluci, Carlos Henrique Fachin Soto, Claudio Alberto Tellez Ferraresi, Cleber |
author_role |
author |
author2 |
de Paiva Carvalho, Rodrigo Leal [UNESP] Junior, Geraldo Marco Rosa Tavares, Beatriz Antoniassi Simionato, Luis Henrique Bortoluci, Carlos Henrique Fachin Soto, Claudio Alberto Tellez Ferraresi, Cleber |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Brasil Universidade Estadual Paulista (Unesp) Bauru |
dc.contributor.author.fl_str_mv |
Castro, Kenia Mendes Rodrigues de Paiva Carvalho, Rodrigo Leal [UNESP] Junior, Geraldo Marco Rosa Tavares, Beatriz Antoniassi Simionato, Luis Henrique Bortoluci, Carlos Henrique Fachin Soto, Claudio Alberto Tellez Ferraresi, Cleber |
dc.subject.por.fl_str_mv |
Blood glucose Diabetes mellitus Glycogen LED therapy Low-level laser therapy |
topic |
Blood glucose Diabetes mellitus Glycogen LED therapy Low-level laser therapy |
description |
Photobiomodulation therapy (PBMT) has many effects on the energy metabolism of musculoskeletal tissue, such as increased glycogen and adenosine triphosphate synthesis. In addition, these effects may be due to a systemic blood glucose control. Twenty-four Wistar rats were randomly and equally allocated into four groups: sham, PBMT 10 J/cm2, PBMT 30 J/cm2 and PBMT 60 J/cm2. The animals were fasting for 6 h for blood glucose evaluations during pre-irradiation period, 1 h, 3 h and 6 h after PBMT. Muscle glycogen synthesis was measured 24 h after PBMT. This PBMT used a cluster of 69 LEDs (light-emitting diodes) with 35 red (630 ± 10 nm) and 34 infrared (850 ± 20 nm); 114 mW/cm2 for 90s (10 J/cm2), 270 s (30 J/cm2), 540 s (60 J/cm2) applied on large muscle areas (back and hind legs) of the animals. The 10 J/cm2 group showed lower blood glucose levels and glucose variability over 6 h (5.92 mg/dL) compared to the sham (13.03 mg/dL), 30 J/cm2 (7.77 mg/dL) and 60 J/cm2 (9.07 mg/dL) groups. The PBMT groups had the greatest increase in muscle glycogen (10 J/cm2 > 60 J/cm2 > 30 J/cm2 > sham), characterizing a triphasic dose-response of PBMT. There was a strong negative correlation between blood glucose variability over 6 h and muscle glycogen concentration for 10 J/cm2 group (r = −0.94; p < .001) followed by 30 J/cm2 group (r = −0.84; p < .001) and 60 J/cm2 group(r = −0.73; p < .006). These results suggest that PBMT can play a very important role in the control of blood glucose levels, and its possible mechanism of action is the induction of greater muscle glycogen synthesis independently of physical exercise. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:01:54Z 2020-12-12T02:01:54Z 2020-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jphotobiol.2020.111877 Journal of Photochemistry and Photobiology B: Biology, v. 207. 1873-2682 1011-1344 http://hdl.handle.net/11449/200261 10.1016/j.jphotobiol.2020.111877 2-s2.0-85083062940 |
url |
http://dx.doi.org/10.1016/j.jphotobiol.2020.111877 http://hdl.handle.net/11449/200261 |
identifier_str_mv |
Journal of Photochemistry and Photobiology B: Biology, v. 207. 1873-2682 1011-1344 10.1016/j.jphotobiol.2020.111877 2-s2.0-85083062940 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Photochemistry and Photobiology B: Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649725600104448 |