Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jfms.2008.12.003 http://hdl.handle.net/11449/225471 |
Resumo: | A randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5 mg/kg PO (V), tramadol 2 mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0 ± 0.32 kg; 1.8 ± 0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52 h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5 mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats. © 2009 ESFM and AAFP. |
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Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in catsA randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5 mg/kg PO (V), tramadol 2 mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0 ± 0.32 kg; 1.8 ± 0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52 h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5 mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats. © 2009 ESFM and AAFP.Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University, Botucatu, São PauloDepartment of Biostatistics Institute of Biosciences São Paulo State University, Botucatu, São PauloDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University, Botucatu, São PauloDepartment of Biostatistics Institute of Biosciences São Paulo State University, Botucatu, São PauloUniversidade Estadual Paulista (UNESP)Brondani, Juliana T. [UNESP]Luna, Stelio P.L. [UNESP]Marcello, Gracy C.G. [UNESP]Padovani, Carlos R. [UNESP]2022-04-28T20:51:53Z2022-04-28T20:51:53Z2009-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article503-509http://dx.doi.org/10.1016/j.jfms.2008.12.003Journal of Feline Medicine and Surgery, v. 11, n. 6, p. 503-509, 2009.1098-612Xhttp://hdl.handle.net/11449/22547110.1016/j.jfms.2008.12.0032-s2.0-65649085927Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Feline Medicine and Surgeryinfo:eu-repo/semantics/openAccess2022-04-28T20:51:53Zoai:repositorio.unesp.br:11449/225471Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T20:51:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats |
title |
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats |
spellingShingle |
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats Brondani, Juliana T. [UNESP] |
title_short |
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats |
title_full |
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats |
title_fullStr |
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats |
title_full_unstemmed |
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats |
title_sort |
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats |
author |
Brondani, Juliana T. [UNESP] |
author_facet |
Brondani, Juliana T. [UNESP] Luna, Stelio P.L. [UNESP] Marcello, Gracy C.G. [UNESP] Padovani, Carlos R. [UNESP] |
author_role |
author |
author2 |
Luna, Stelio P.L. [UNESP] Marcello, Gracy C.G. [UNESP] Padovani, Carlos R. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Brondani, Juliana T. [UNESP] Luna, Stelio P.L. [UNESP] Marcello, Gracy C.G. [UNESP] Padovani, Carlos R. [UNESP] |
description |
A randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5 mg/kg PO (V), tramadol 2 mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0 ± 0.32 kg; 1.8 ± 0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52 h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5 mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats. © 2009 ESFM and AAFP. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-01 2022-04-28T20:51:53Z 2022-04-28T20:51:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jfms.2008.12.003 Journal of Feline Medicine and Surgery, v. 11, n. 6, p. 503-509, 2009. 1098-612X http://hdl.handle.net/11449/225471 10.1016/j.jfms.2008.12.003 2-s2.0-65649085927 |
url |
http://dx.doi.org/10.1016/j.jfms.2008.12.003 http://hdl.handle.net/11449/225471 |
identifier_str_mv |
Journal of Feline Medicine and Surgery, v. 11, n. 6, p. 503-509, 2009. 1098-612X 10.1016/j.jfms.2008.12.003 2-s2.0-65649085927 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Feline Medicine and Surgery |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
503-509 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965219463626752 |