Drug delivery systems for local anesthetics

Detalhes bibliográficos
Autor(a) principal: de Paula, Eneida
Data de Publicação: 2010
Outros Autores: Cereda, Cíntia M.S., Tofoli, Giovana R., Franz-Montan, Michelle, Fraceto, Leonardo F. [UNESP], De Araújo, Daniele R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2174/187221110789957228
http://hdl.handle.net/11449/225781
Resumo: Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to systemically deliver LA include the encapsulation in liposomes, complexation in cyclodextrins, association with biopolymers and others carrier systems. Topical delivery systems for LA are characteristically composed by a diversity of adjuvants (viscosity inducing agents, preservatives, permeation enhancers, emollients,...) and presentations such as semisolid (gel, creams, ointments), liquid (o/w and w/o emulsions, dispersions) and solid (patches) pharmaceutical forms. The proposed formulations aim to reduce the LA concentration used, increase its permeability and absorption, keep the LA at the target site for longer periods prolonging the anesthetic or analgesic effect and, finally, to decrease the clearance, local and systemic toxicity. This review deals with the innovations pertaining to formulations and techniques for drug delivery of topical and injectable local anesthetics, as described in recent patents. © 2010 Bentham Science Publishers Ltd.
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spelling Drug delivery systems for local anestheticsCyclodextrinsLiposomesLocal anestheticsMicro and nanoparticlesPolymersTopical formulationsAlthough technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to systemically deliver LA include the encapsulation in liposomes, complexation in cyclodextrins, association with biopolymers and others carrier systems. Topical delivery systems for LA are characteristically composed by a diversity of adjuvants (viscosity inducing agents, preservatives, permeation enhancers, emollients,...) and presentations such as semisolid (gel, creams, ointments), liquid (o/w and w/o emulsions, dispersions) and solid (patches) pharmaceutical forms. The proposed formulations aim to reduce the LA concentration used, increase its permeability and absorption, keep the LA at the target site for longer periods prolonging the anesthetic or analgesic effect and, finally, to decrease the clearance, local and systemic toxicity. This review deals with the innovations pertaining to formulations and techniques for drug delivery of topical and injectable local anesthetics, as described in recent patents. © 2010 Bentham Science Publishers Ltd.Department of Biochemistry Institute of Biology State University of Campinas, S/N, Barao Geraldo, CEP 13083-970, Campinas, SPDepartment of Environmental Engineering Julio de Mesquita Filho State University, Sorocaba, SPNatural and Human Science Center ABC Federal University, Santo André, SPDepartment of Environmental Engineering Julio de Mesquita Filho State University, Sorocaba, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)ABC Federal Universityde Paula, EneidaCereda, Cíntia M.S.Tofoli, Giovana R.Franz-Montan, MichelleFraceto, Leonardo F. [UNESP]De Araújo, Daniele R.2022-04-28T20:59:56Z2022-04-28T20:59:56Z2010-06-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article23-34http://dx.doi.org/10.2174/187221110789957228Recent Patents on Drug Delivery and Formulation, v. 4, n. 1, p. 23-34, 2010.1872-2113http://hdl.handle.net/11449/22578110.2174/1872211107899572282-s2.0-77449102069Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRecent Patents on Drug Delivery and Formulationinfo:eu-repo/semantics/openAccess2022-04-28T20:59:56Zoai:repositorio.unesp.br:11449/225781Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:51:38.733263Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Drug delivery systems for local anesthetics
title Drug delivery systems for local anesthetics
spellingShingle Drug delivery systems for local anesthetics
de Paula, Eneida
Cyclodextrins
Liposomes
Local anesthetics
Micro and nanoparticles
Polymers
Topical formulations
title_short Drug delivery systems for local anesthetics
title_full Drug delivery systems for local anesthetics
title_fullStr Drug delivery systems for local anesthetics
title_full_unstemmed Drug delivery systems for local anesthetics
title_sort Drug delivery systems for local anesthetics
author de Paula, Eneida
author_facet de Paula, Eneida
Cereda, Cíntia M.S.
Tofoli, Giovana R.
Franz-Montan, Michelle
Fraceto, Leonardo F. [UNESP]
De Araújo, Daniele R.
author_role author
author2 Cereda, Cíntia M.S.
Tofoli, Giovana R.
Franz-Montan, Michelle
Fraceto, Leonardo F. [UNESP]
De Araújo, Daniele R.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
ABC Federal University
dc.contributor.author.fl_str_mv de Paula, Eneida
Cereda, Cíntia M.S.
Tofoli, Giovana R.
Franz-Montan, Michelle
Fraceto, Leonardo F. [UNESP]
De Araújo, Daniele R.
dc.subject.por.fl_str_mv Cyclodextrins
Liposomes
Local anesthetics
Micro and nanoparticles
Polymers
Topical formulations
topic Cyclodextrins
Liposomes
Local anesthetics
Micro and nanoparticles
Polymers
Topical formulations
description Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to systemically deliver LA include the encapsulation in liposomes, complexation in cyclodextrins, association with biopolymers and others carrier systems. Topical delivery systems for LA are characteristically composed by a diversity of adjuvants (viscosity inducing agents, preservatives, permeation enhancers, emollients,...) and presentations such as semisolid (gel, creams, ointments), liquid (o/w and w/o emulsions, dispersions) and solid (patches) pharmaceutical forms. The proposed formulations aim to reduce the LA concentration used, increase its permeability and absorption, keep the LA at the target site for longer periods prolonging the anesthetic or analgesic effect and, finally, to decrease the clearance, local and systemic toxicity. This review deals with the innovations pertaining to formulations and techniques for drug delivery of topical and injectable local anesthetics, as described in recent patents. © 2010 Bentham Science Publishers Ltd.
publishDate 2010
dc.date.none.fl_str_mv 2010-06-25
2022-04-28T20:59:56Z
2022-04-28T20:59:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2174/187221110789957228
Recent Patents on Drug Delivery and Formulation, v. 4, n. 1, p. 23-34, 2010.
1872-2113
http://hdl.handle.net/11449/225781
10.2174/187221110789957228
2-s2.0-77449102069
url http://dx.doi.org/10.2174/187221110789957228
http://hdl.handle.net/11449/225781
identifier_str_mv Recent Patents on Drug Delivery and Formulation, v. 4, n. 1, p. 23-34, 2010.
1872-2113
10.2174/187221110789957228
2-s2.0-77449102069
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Recent Patents on Drug Delivery and Formulation
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 23-34
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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