Drug delivery systems for local anesthetics
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2174/187221110789957228 http://hdl.handle.net/11449/225781 |
Resumo: | Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to systemically deliver LA include the encapsulation in liposomes, complexation in cyclodextrins, association with biopolymers and others carrier systems. Topical delivery systems for LA are characteristically composed by a diversity of adjuvants (viscosity inducing agents, preservatives, permeation enhancers, emollients,...) and presentations such as semisolid (gel, creams, ointments), liquid (o/w and w/o emulsions, dispersions) and solid (patches) pharmaceutical forms. The proposed formulations aim to reduce the LA concentration used, increase its permeability and absorption, keep the LA at the target site for longer periods prolonging the anesthetic or analgesic effect and, finally, to decrease the clearance, local and systemic toxicity. This review deals with the innovations pertaining to formulations and techniques for drug delivery of topical and injectable local anesthetics, as described in recent patents. © 2010 Bentham Science Publishers Ltd. |
id |
UNSP_8c6bd3377713a170ac18107b6d32bcc7 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/225781 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Drug delivery systems for local anestheticsCyclodextrinsLiposomesLocal anestheticsMicro and nanoparticlesPolymersTopical formulationsAlthough technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to systemically deliver LA include the encapsulation in liposomes, complexation in cyclodextrins, association with biopolymers and others carrier systems. Topical delivery systems for LA are characteristically composed by a diversity of adjuvants (viscosity inducing agents, preservatives, permeation enhancers, emollients,...) and presentations such as semisolid (gel, creams, ointments), liquid (o/w and w/o emulsions, dispersions) and solid (patches) pharmaceutical forms. The proposed formulations aim to reduce the LA concentration used, increase its permeability and absorption, keep the LA at the target site for longer periods prolonging the anesthetic or analgesic effect and, finally, to decrease the clearance, local and systemic toxicity. This review deals with the innovations pertaining to formulations and techniques for drug delivery of topical and injectable local anesthetics, as described in recent patents. © 2010 Bentham Science Publishers Ltd.Department of Biochemistry Institute of Biology State University of Campinas, S/N, Barao Geraldo, CEP 13083-970, Campinas, SPDepartment of Environmental Engineering Julio de Mesquita Filho State University, Sorocaba, SPNatural and Human Science Center ABC Federal University, Santo André, SPDepartment of Environmental Engineering Julio de Mesquita Filho State University, Sorocaba, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)ABC Federal Universityde Paula, EneidaCereda, Cíntia M.S.Tofoli, Giovana R.Franz-Montan, MichelleFraceto, Leonardo F. [UNESP]De Araújo, Daniele R.2022-04-28T20:59:56Z2022-04-28T20:59:56Z2010-06-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article23-34http://dx.doi.org/10.2174/187221110789957228Recent Patents on Drug Delivery and Formulation, v. 4, n. 1, p. 23-34, 2010.1872-2113http://hdl.handle.net/11449/22578110.2174/1872211107899572282-s2.0-77449102069Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRecent Patents on Drug Delivery and Formulationinfo:eu-repo/semantics/openAccess2022-04-28T20:59:56Zoai:repositorio.unesp.br:11449/225781Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:51:38.733263Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Drug delivery systems for local anesthetics |
title |
Drug delivery systems for local anesthetics |
spellingShingle |
Drug delivery systems for local anesthetics de Paula, Eneida Cyclodextrins Liposomes Local anesthetics Micro and nanoparticles Polymers Topical formulations |
title_short |
Drug delivery systems for local anesthetics |
title_full |
Drug delivery systems for local anesthetics |
title_fullStr |
Drug delivery systems for local anesthetics |
title_full_unstemmed |
Drug delivery systems for local anesthetics |
title_sort |
Drug delivery systems for local anesthetics |
author |
de Paula, Eneida |
author_facet |
de Paula, Eneida Cereda, Cíntia M.S. Tofoli, Giovana R. Franz-Montan, Michelle Fraceto, Leonardo F. [UNESP] De Araújo, Daniele R. |
author_role |
author |
author2 |
Cereda, Cíntia M.S. Tofoli, Giovana R. Franz-Montan, Michelle Fraceto, Leonardo F. [UNESP] De Araújo, Daniele R. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (UNESP) ABC Federal University |
dc.contributor.author.fl_str_mv |
de Paula, Eneida Cereda, Cíntia M.S. Tofoli, Giovana R. Franz-Montan, Michelle Fraceto, Leonardo F. [UNESP] De Araújo, Daniele R. |
dc.subject.por.fl_str_mv |
Cyclodextrins Liposomes Local anesthetics Micro and nanoparticles Polymers Topical formulations |
topic |
Cyclodextrins Liposomes Local anesthetics Micro and nanoparticles Polymers Topical formulations |
description |
Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to systemically deliver LA include the encapsulation in liposomes, complexation in cyclodextrins, association with biopolymers and others carrier systems. Topical delivery systems for LA are characteristically composed by a diversity of adjuvants (viscosity inducing agents, preservatives, permeation enhancers, emollients,...) and presentations such as semisolid (gel, creams, ointments), liquid (o/w and w/o emulsions, dispersions) and solid (patches) pharmaceutical forms. The proposed formulations aim to reduce the LA concentration used, increase its permeability and absorption, keep the LA at the target site for longer periods prolonging the anesthetic or analgesic effect and, finally, to decrease the clearance, local and systemic toxicity. This review deals with the innovations pertaining to formulations and techniques for drug delivery of topical and injectable local anesthetics, as described in recent patents. © 2010 Bentham Science Publishers Ltd. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06-25 2022-04-28T20:59:56Z 2022-04-28T20:59:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2174/187221110789957228 Recent Patents on Drug Delivery and Formulation, v. 4, n. 1, p. 23-34, 2010. 1872-2113 http://hdl.handle.net/11449/225781 10.2174/187221110789957228 2-s2.0-77449102069 |
url |
http://dx.doi.org/10.2174/187221110789957228 http://hdl.handle.net/11449/225781 |
identifier_str_mv |
Recent Patents on Drug Delivery and Formulation, v. 4, n. 1, p. 23-34, 2010. 1872-2113 10.2174/187221110789957228 2-s2.0-77449102069 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Recent Patents on Drug Delivery and Formulation |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
23-34 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128711047774208 |