The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2019/9464768 http://hdl.handle.net/11449/189235 |
Resumo: | Yellow fever (YF) is a zoonotic arthropod-borne disease that is caused by the yellow fever virus (YFV) and characterized by a sylvatic and urban cycle. Its most severe presentation is manifested as a hemorrhagic disease, and it has been responsible for thousands of deaths in the last decades. This study describes the public health approaches taken to control the 2016-2017 YF outbreak in nonhuman primates (NHPs) that took place in the northeastern region of São Paulo state, Brazil. NHPs recovered from the field were necropsied, and YF diagnoses were made at the Laboratory of Molecular Virology, Ribeirão Preto Medical School and the Center of Pathology, Adolfo Lutz Institute of São Paulo. NHP samples were inoculated into Vero cells for YFV isolation. RNA extraction was performed directly from NHP tissues and tested by RT-qPCR. YFV-positive samples were confirmed by sequencing. Based on the rapid RT-qPCR results, surveillance actions were implemented in the entire region. Confirmatory histopathology and immunohistochemistry for YFV were also performed. Among nine NHPs, gross hepatic involvement was observed in six animals, five of which were YFV-RT-qPCR-positive. One YFV was isolated from the serum of an infant NHP. YFV RNA sequences diverged from the virus responsible for the last epizootic that occurred in São Paulo state, but it was similar to the current Brazilian epizootic. Public health actions included dissemination of information on YF transmission, investigation of the probable location of NHP infection, characterization of the environment, and subsequent creation of the blueprint from which prevention and control measures were implemented. The YFV sylvatic cycle occurred in the periurban areas of the northeastern region of São Paulo state, but no human cases were reported during this period, showing that integrated actions between human, animal, and environmental health professionals were critical to restrain the virus to the sylvatic cycle. |
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The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo StateYellow fever (YF) is a zoonotic arthropod-borne disease that is caused by the yellow fever virus (YFV) and characterized by a sylvatic and urban cycle. Its most severe presentation is manifested as a hemorrhagic disease, and it has been responsible for thousands of deaths in the last decades. This study describes the public health approaches taken to control the 2016-2017 YF outbreak in nonhuman primates (NHPs) that took place in the northeastern region of São Paulo state, Brazil. NHPs recovered from the field were necropsied, and YF diagnoses were made at the Laboratory of Molecular Virology, Ribeirão Preto Medical School and the Center of Pathology, Adolfo Lutz Institute of São Paulo. NHP samples were inoculated into Vero cells for YFV isolation. RNA extraction was performed directly from NHP tissues and tested by RT-qPCR. YFV-positive samples were confirmed by sequencing. Based on the rapid RT-qPCR results, surveillance actions were implemented in the entire region. Confirmatory histopathology and immunohistochemistry for YFV were also performed. Among nine NHPs, gross hepatic involvement was observed in six animals, five of which were YFV-RT-qPCR-positive. One YFV was isolated from the serum of an infant NHP. YFV RNA sequences diverged from the virus responsible for the last epizootic that occurred in São Paulo state, but it was similar to the current Brazilian epizootic. Public health actions included dissemination of information on YF transmission, investigation of the probable location of NHP infection, characterization of the environment, and subsequent creation of the blueprint from which prevention and control measures were implemented. The YFV sylvatic cycle occurred in the periurban areas of the northeastern region of São Paulo state, but no human cases were reported during this period, showing that integrated actions between human, animal, and environmental health professionals were critical to restrain the virus to the sylvatic cycle.Department of Internal Medicine Ribeirão Preto Medical School University of São Paulo FMRP/USP, Av. Bandeirantes, 3900, Vila Monte AlegreVeterinary Preventive Medicine and Animal Reproduction Department Faculty of Agricultural and Veterinary Sciences Universidade Estadual Paulista Júlio de Mesquita Filho (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/nAnimal Pathology Department Faculty of Agricultural and Veterinary Sciences Universidade Estadual Paulista Júlio de Mesquita Filho (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/nMunicipal Health Secretary, Av. General Glicério, 569, CenterNucleus of Pathological Anatomy Pathology Center Adolfo Lutz Institute of São Paulo State Secretary of Health, Av. Dr. Arnaldo, 351Veterinary Preventive Medicine and Animal Reproduction Department Faculty of Agricultural and Veterinary Sciences Universidade Estadual Paulista Júlio de Mesquita Filho (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/nAnimal Pathology Department Faculty of Agricultural and Veterinary Sciences Universidade Estadual Paulista Júlio de Mesquita Filho (FCAV/Unesp), Access Way Prof. Paulo Donato Castellane s/nUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Municipal Health SecretaryState Secretary of HealthSiconelli, Márcio Junio LimaEspósito, Danillo Lucas AlvesMoraes, Nathália Cristina [UNESP]Ribeiro, Julia Maria [UNESP]Perles, Lívia [UNESP]Dias, Maria AngélicaCarvalho, Adolorata Aparecida Bianco [UNESP]Werther, Karin [UNESP]Fernandes, Natália Coelho Couto De AzevedoIglezias, Silvia D'AndrettaBürger, Karina Paes [UNESP]Fonseca, Benedito Antonio Lopes DaChochlakis, Dimosthenis2019-10-06T16:34:19Z2019-10-06T16:34:19Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1155/2019/9464768Canadian Journal of Infectious Diseases and Medical Microbiology, v. 2019.1918-14931712-9532http://hdl.handle.net/11449/18923510.1155/2019/94647682-s2.0-85067080944Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCanadian Journal of Infectious Diseases and Medical Microbiologyinfo:eu-repo/semantics/openAccess2021-10-23T16:30:50Zoai:repositorio.unesp.br:11449/189235Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T16:30:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
title |
The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
spellingShingle |
The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State Siconelli, Márcio Junio Lima |
title_short |
The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
title_full |
The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
title_fullStr |
The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
title_full_unstemmed |
The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
title_sort |
The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State |
author |
Siconelli, Márcio Junio Lima |
author_facet |
Siconelli, Márcio Junio Lima Espósito, Danillo Lucas Alves Moraes, Nathália Cristina [UNESP] Ribeiro, Julia Maria [UNESP] Perles, Lívia [UNESP] Dias, Maria Angélica Carvalho, Adolorata Aparecida Bianco [UNESP] Werther, Karin [UNESP] Fernandes, Natália Coelho Couto De Azevedo Iglezias, Silvia D'Andretta Bürger, Karina Paes [UNESP] Fonseca, Benedito Antonio Lopes Da Chochlakis, Dimosthenis |
author_role |
author |
author2 |
Espósito, Danillo Lucas Alves Moraes, Nathália Cristina [UNESP] Ribeiro, Julia Maria [UNESP] Perles, Lívia [UNESP] Dias, Maria Angélica Carvalho, Adolorata Aparecida Bianco [UNESP] Werther, Karin [UNESP] Fernandes, Natália Coelho Couto De Azevedo Iglezias, Silvia D'Andretta Bürger, Karina Paes [UNESP] Fonseca, Benedito Antonio Lopes Da Chochlakis, Dimosthenis |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Municipal Health Secretary State Secretary of Health |
dc.contributor.author.fl_str_mv |
Siconelli, Márcio Junio Lima Espósito, Danillo Lucas Alves Moraes, Nathália Cristina [UNESP] Ribeiro, Julia Maria [UNESP] Perles, Lívia [UNESP] Dias, Maria Angélica Carvalho, Adolorata Aparecida Bianco [UNESP] Werther, Karin [UNESP] Fernandes, Natália Coelho Couto De Azevedo Iglezias, Silvia D'Andretta Bürger, Karina Paes [UNESP] Fonseca, Benedito Antonio Lopes Da Chochlakis, Dimosthenis |
description |
Yellow fever (YF) is a zoonotic arthropod-borne disease that is caused by the yellow fever virus (YFV) and characterized by a sylvatic and urban cycle. Its most severe presentation is manifested as a hemorrhagic disease, and it has been responsible for thousands of deaths in the last decades. This study describes the public health approaches taken to control the 2016-2017 YF outbreak in nonhuman primates (NHPs) that took place in the northeastern region of São Paulo state, Brazil. NHPs recovered from the field were necropsied, and YF diagnoses were made at the Laboratory of Molecular Virology, Ribeirão Preto Medical School and the Center of Pathology, Adolfo Lutz Institute of São Paulo. NHP samples were inoculated into Vero cells for YFV isolation. RNA extraction was performed directly from NHP tissues and tested by RT-qPCR. YFV-positive samples were confirmed by sequencing. Based on the rapid RT-qPCR results, surveillance actions were implemented in the entire region. Confirmatory histopathology and immunohistochemistry for YFV were also performed. Among nine NHPs, gross hepatic involvement was observed in six animals, five of which were YFV-RT-qPCR-positive. One YFV was isolated from the serum of an infant NHP. YFV RNA sequences diverged from the virus responsible for the last epizootic that occurred in São Paulo state, but it was similar to the current Brazilian epizootic. Public health actions included dissemination of information on YF transmission, investigation of the probable location of NHP infection, characterization of the environment, and subsequent creation of the blueprint from which prevention and control measures were implemented. The YFV sylvatic cycle occurred in the periurban areas of the northeastern region of São Paulo state, but no human cases were reported during this period, showing that integrated actions between human, animal, and environmental health professionals were critical to restrain the virus to the sylvatic cycle. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:34:19Z 2019-10-06T16:34:19Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2019/9464768 Canadian Journal of Infectious Diseases and Medical Microbiology, v. 2019. 1918-1493 1712-9532 http://hdl.handle.net/11449/189235 10.1155/2019/9464768 2-s2.0-85067080944 |
url |
http://dx.doi.org/10.1155/2019/9464768 http://hdl.handle.net/11449/189235 |
identifier_str_mv |
Canadian Journal of Infectious Diseases and Medical Microbiology, v. 2019. 1918-1493 1712-9532 10.1155/2019/9464768 2-s2.0-85067080944 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Canadian Journal of Infectious Diseases and Medical Microbiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964450991636480 |