Aspectos estruturais da membrana eritrocitária

Detalhes bibliográficos
Autor(a) principal: Murador, Priscila [UNESP]
Data de Publicação: 2007
Outros Autores: Deffune, Elenice [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1516-84842007000200016
http://hdl.handle.net/11449/69605
Resumo: This article describes the structures and functions of the erythrocyte membrane and its importance in transfusional medicine. The erythrocyte membrane is one of the best known membranes in terms of structure, function and genetic disorders. As any other plasma membrane, it mediates transport functions. It also provides the erythrocytes with their resilience and deformability. According to the International Society of Blood Transfusion (ISBT), more than 500 antigens are expressed in the erythrocyte membrane, and around 270 are involved in transfusion reaction cases and hemolytic diseases of the fetus and newborn. In the ISBT classification, the high frequency series is represented by antigens in more than 99% of population (high prevalence antigen). In transfusion, the absence of these antigens determines severe problems as for example, one woman without the P antigen suffered 6 repetitive miscarriages due to placental insufficiency, which was caused by an antibody formed against the absent P antigen. Some important erythrocyte membrane proteins are described here including Band 3, Glycophorins and spectrin. The most abundant integral membrane protein is Band 3 and its main function is to mediate exchange of chloride and bicarbonate anions across the plasma membrane. The second most abundant integral membrane protein in the human erythrocyte is sialoglycoprotein glycophorin A (GPA). With its high sialic acid content, GPA is the main contributor to the net negative cell-surface charge and is thus critical for minimizing cell-cell interactions and preventing red cell aggregation. Glycophorin C (GPC) is the receptor for PfEBP-2 (baebl, EBA-140), the newly identified erythrocyte binding ligand of Plasmodium falciparum. The ternary complex of spectrin, actin and 4.1R defines the nodes of the erythrocyte membrane skeletal network, and is inseparable from membrane stability when under mechanical stress. This erythrocyte membrane review is important for a better understanding of transfusion reactions, where the antibody formation against high prevalence antigens makes compatible transfusions difficult. The study of antigen diversity and biochemical characterization of different proteins will contribute to healthcare, as well as diagnosis, development of technology such as monoclonal antibody production and the therapeutic conduct of many diseases.
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spelling Aspectos estruturais da membrana eritrocitáriaStructural aspects of the erythrocyte membraneAntigensErythrocyte membraneGlycophorinsProteinsThis article describes the structures and functions of the erythrocyte membrane and its importance in transfusional medicine. The erythrocyte membrane is one of the best known membranes in terms of structure, function and genetic disorders. As any other plasma membrane, it mediates transport functions. It also provides the erythrocytes with their resilience and deformability. According to the International Society of Blood Transfusion (ISBT), more than 500 antigens are expressed in the erythrocyte membrane, and around 270 are involved in transfusion reaction cases and hemolytic diseases of the fetus and newborn. In the ISBT classification, the high frequency series is represented by antigens in more than 99% of population (high prevalence antigen). In transfusion, the absence of these antigens determines severe problems as for example, one woman without the P antigen suffered 6 repetitive miscarriages due to placental insufficiency, which was caused by an antibody formed against the absent P antigen. Some important erythrocyte membrane proteins are described here including Band 3, Glycophorins and spectrin. The most abundant integral membrane protein is Band 3 and its main function is to mediate exchange of chloride and bicarbonate anions across the plasma membrane. The second most abundant integral membrane protein in the human erythrocyte is sialoglycoprotein glycophorin A (GPA). With its high sialic acid content, GPA is the main contributor to the net negative cell-surface charge and is thus critical for minimizing cell-cell interactions and preventing red cell aggregation. Glycophorin C (GPC) is the receptor for PfEBP-2 (baebl, EBA-140), the newly identified erythrocyte binding ligand of Plasmodium falciparum. The ternary complex of spectrin, actin and 4.1R defines the nodes of the erythrocyte membrane skeletal network, and is inseparable from membrane stability when under mechanical stress. This erythrocyte membrane review is important for a better understanding of transfusion reactions, where the antibody formation against high prevalence antigens makes compatible transfusions difficult. The study of antigen diversity and biochemical characterization of different proteins will contribute to healthcare, as well as diagnosis, development of technology such as monoclonal antibody production and the therapeutic conduct of many diseases.Hemocentro Faculdade de Medicina de BotucatuHemocentro de BotucatuUniversidade Pierre et Marie Curie - IV, ParisDepto. de Urologia Fac. de Medicina de Botucatu (Unesp)Hosp. Das Clínicas da Faculdade de Medicina de Botucatu Divisão Hemocentro Lab. de Engenharia Celular, Distrito de Rubião Jr. s/n, 18618-000 - Botucatu-SPHemocentro Faculdade de Medicina de BotucatuDepto. de Urologia Fac. de Medicina de Botucatu (Unesp)Hosp. Das Clínicas da Faculdade de Medicina de Botucatu Divisão Hemocentro Lab. de Engenharia Celular, Distrito de Rubião Jr. s/n, 18618-000 - Botucatu-SPUniversidade Estadual Paulista (Unesp)Hemocentro de BotucatuUniversidade Pierre et Marie Curie - IVMurador, Priscila [UNESP]Deffune, Elenice [UNESP]2014-05-27T11:22:27Z2014-05-27T11:22:27Z2007-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article168-178application/pdfhttp://dx.doi.org/10.1590/S1516-84842007000200016Revista Brasileira de Hematologia e Hemoterapia, v. 29, n. 2, p. 168-178, 2007.1516-8484http://hdl.handle.net/11449/6960510.1590/S1516-84842007000200016S1516-848420070002000162-s2.0-373490254822-s2.0-37349025482.pdf9646764071339214Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Hematologia e Hemoterapia0,335info:eu-repo/semantics/openAccess2024-09-03T14:29:54Zoai:repositorio.unesp.br:11449/69605Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:29:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Aspectos estruturais da membrana eritrocitária
Structural aspects of the erythrocyte membrane
title Aspectos estruturais da membrana eritrocitária
spellingShingle Aspectos estruturais da membrana eritrocitária
Murador, Priscila [UNESP]
Antigens
Erythrocyte membrane
Glycophorins
Proteins
title_short Aspectos estruturais da membrana eritrocitária
title_full Aspectos estruturais da membrana eritrocitária
title_fullStr Aspectos estruturais da membrana eritrocitária
title_full_unstemmed Aspectos estruturais da membrana eritrocitária
title_sort Aspectos estruturais da membrana eritrocitária
author Murador, Priscila [UNESP]
author_facet Murador, Priscila [UNESP]
Deffune, Elenice [UNESP]
author_role author
author2 Deffune, Elenice [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Hemocentro de Botucatu
Universidade Pierre et Marie Curie - IV
dc.contributor.author.fl_str_mv Murador, Priscila [UNESP]
Deffune, Elenice [UNESP]
dc.subject.por.fl_str_mv Antigens
Erythrocyte membrane
Glycophorins
Proteins
topic Antigens
Erythrocyte membrane
Glycophorins
Proteins
description This article describes the structures and functions of the erythrocyte membrane and its importance in transfusional medicine. The erythrocyte membrane is one of the best known membranes in terms of structure, function and genetic disorders. As any other plasma membrane, it mediates transport functions. It also provides the erythrocytes with their resilience and deformability. According to the International Society of Blood Transfusion (ISBT), more than 500 antigens are expressed in the erythrocyte membrane, and around 270 are involved in transfusion reaction cases and hemolytic diseases of the fetus and newborn. In the ISBT classification, the high frequency series is represented by antigens in more than 99% of population (high prevalence antigen). In transfusion, the absence of these antigens determines severe problems as for example, one woman without the P antigen suffered 6 repetitive miscarriages due to placental insufficiency, which was caused by an antibody formed against the absent P antigen. Some important erythrocyte membrane proteins are described here including Band 3, Glycophorins and spectrin. The most abundant integral membrane protein is Band 3 and its main function is to mediate exchange of chloride and bicarbonate anions across the plasma membrane. The second most abundant integral membrane protein in the human erythrocyte is sialoglycoprotein glycophorin A (GPA). With its high sialic acid content, GPA is the main contributor to the net negative cell-surface charge and is thus critical for minimizing cell-cell interactions and preventing red cell aggregation. Glycophorin C (GPC) is the receptor for PfEBP-2 (baebl, EBA-140), the newly identified erythrocyte binding ligand of Plasmodium falciparum. The ternary complex of spectrin, actin and 4.1R defines the nodes of the erythrocyte membrane skeletal network, and is inseparable from membrane stability when under mechanical stress. This erythrocyte membrane review is important for a better understanding of transfusion reactions, where the antibody formation against high prevalence antigens makes compatible transfusions difficult. The study of antigen diversity and biochemical characterization of different proteins will contribute to healthcare, as well as diagnosis, development of technology such as monoclonal antibody production and the therapeutic conduct of many diseases.
publishDate 2007
dc.date.none.fl_str_mv 2007-04-01
2014-05-27T11:22:27Z
2014-05-27T11:22:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-84842007000200016
Revista Brasileira de Hematologia e Hemoterapia, v. 29, n. 2, p. 168-178, 2007.
1516-8484
http://hdl.handle.net/11449/69605
10.1590/S1516-84842007000200016
S1516-84842007000200016
2-s2.0-37349025482
2-s2.0-37349025482.pdf
9646764071339214
url http://dx.doi.org/10.1590/S1516-84842007000200016
http://hdl.handle.net/11449/69605
identifier_str_mv Revista Brasileira de Hematologia e Hemoterapia, v. 29, n. 2, p. 168-178, 2007.
1516-8484
10.1590/S1516-84842007000200016
S1516-84842007000200016
2-s2.0-37349025482
2-s2.0-37349025482.pdf
9646764071339214
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia
0,335
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 168-178
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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