Efeito do estresse crônico e benzodiazepínicos no reparo ósseo: estudo histológico em ratos

• Autor(a) principal: Rezende, Maria Cristina Rosifini Alves [UNESP]
• Data de Publicação: 2010
• Outros Autores: Kusuda, Ricardo, Mari, Gustavo Galhego [UNESP], Alves, Luciana Mara Negrão [UNESP], Marinho, Márcio Von Dreiffus [UNESP], Felipini, Renata Callestini [UNESP], Okamoto, Roberta [UNESP], Okamoto, Tetuo [UNESP], Alves-Rezende, Luís Guilherme Rosifini, Garcia-da-Silva, Tales Cândido [UNESP], Alves-Claro, Ana Paula Rosifini [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://apcdaracatuba.com.br/revista/Volume_31_01_Jan_2010/v31n1.htm; http://hdl.handle.net/11449/133210
• topic: Hypothalamo-hypophyseal system; Pituitary-adrenal system; GABA modulators; Wound healing; Sistema hipotálamo-hipofisário; Sistema hipófise-supra-renal; Moduladores do Gaba; Cicatrização de feridas

Stress is an environmental factor that may predispose individuals to depression. Benzodiazepines have been prescribed as effective drugs in these situations. The purpose of this study was histological evaluate of the effect of chronic stress and benzodiazepine drugs on bone healing. Bone cavities were created in both tibias of 40 male rats were divided into two groups: Control and Treaty. In this, the stressor stimulus was applied 40 days pre-operative and all post-operative days until sacrifice in the morning for 2 hours, by immobilizing restraint. These animals also received diazepam benzodiazepine group, daily, at a concentration of 5mg/Kg/peso body within 15 days of preoperative. In groups of five animals were sacrificed at 7, 14, 30 and 60 days post-surgery. At 7 days postoperatively, while the control group exhibited tissue rich in fibroblasts, the treated group showed newly formed tissue with few fibroblasts and capillaries along with lymphocytes and macrophages. At 14 days postsurgery, the control group showed newly formed trabecular bone while the treated group progressed to thin trabecular bone with numerous osteoblasts on their borders. At 30 days post-operative bone healing is complete in both groups. At 60 days post-operative characteristics observed in the treated and control groups are similar to the previous period, but with more advanced osteogenesis.