Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.archger.2017.07.002 http://hdl.handle.net/11449/163398 |
Resumo: | Objectives: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated with cognitive decline in executive function in the short-term. Method: We analyzed 43 individuals (23 MetS, 20 controls) using a global geriatric evaluation, a neuropsychological battery, and task-related (attention) fMRI exam. Correlation analysis between the fMRI signal at baseline and cognitive impairment after 1 year was based on the voxel-based Pearson coefficient, corrected for multiple comparisons. Results: At baseline, MetS patients showed reduced brain response in frontal and parietal regions compared to controls. After one year, the MetS group also showed a decline in verbal fluency performance. fMRI response in the right dorsolateral prefrontal cortex and bilateral parietal lobes was negatively correlated with verbal fluency decline in the MetS group. Discussion: Our results provide an early biomarker of the possible development of cognitive impairment, particularly in the executive function, of elderly individuals suffering from MetS. These findings also point to an up or down regulation which could be interpreted as compensatory mechanism for possible brain tissue burden caused by MetS. |
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Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndromeMetabolic syndromeElderlyBiomarkerNeuropsychological assessmentCognitive impairmentFunctional magnetic resonanceObjectives: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated with cognitive decline in executive function in the short-term. Method: We analyzed 43 individuals (23 MetS, 20 controls) using a global geriatric evaluation, a neuropsychological battery, and task-related (attention) fMRI exam. Correlation analysis between the fMRI signal at baseline and cognitive impairment after 1 year was based on the voxel-based Pearson coefficient, corrected for multiple comparisons. Results: At baseline, MetS patients showed reduced brain response in frontal and parietal regions compared to controls. After one year, the MetS group also showed a decline in verbal fluency performance. fMRI response in the right dorsolateral prefrontal cortex and bilateral parietal lobes was negatively correlated with verbal fluency decline in the MetS group. Discussion: Our results provide an early biomarker of the possible development of cognitive impairment, particularly in the executive function, of elderly individuals suffering from MetS. These findings also point to an up or down regulation which could be interpreted as compensatory mechanism for possible brain tissue burden caused by MetS.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Ministry of Health which, via Technical Area of Health of Aged (PROADI)Hospital Israelita Albert Einstein under Support Program for Institutional Development of Brazilian Unified National Health System (SUS)Univ Fed Sao Paulo, Escola Paulista Med, Dept Psychiat, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, BrazilHosp Israelita Albert Einstein, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, BrazilHosp Israelita Albert Einstein, Ave Albert Einstein, Sao Paulo, BrazilHosp Israelita Albert Einstein, Rua Madre Cabrini 462, BR-04020001 Sao Paulo, SP, BrazilUniv Estadual Sao Paulo Julio de Mesquita Filho, Fac Med Botucatu, Dept Internal Med, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Internal Med, Div Geriatr, Rua Francisco de Castro 105, BR-04020050 Sao Paulo, SP, BrazilUniv Estadual Sao Paulo Julio de Mesquita Filho, Fac Med Botucatu, Dept Internal Med, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, BrazilCAPES: 2009/12271-3Elsevier B.V.Universidade Federal de São Paulo (UNIFESP)Hosp Israelita Albert EinsteinUniversidade Estadual Paulista (Unesp)Shigaeff, NadiaAmaro, EdsonFranco, Fabio G. M.Jacinto, Alessandro F. [UNESP]Chiochetta, GabrielaCendoroglo, Maysa S.Citero, Vanessa A.2018-11-26T17:41:51Z2018-11-26T17:41:51Z2017-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-7application/pdfhttp://dx.doi.org/10.1016/j.archger.2017.07.002Archives Of Gerontology And Geriatrics. Clare: Elsevier Ireland Ltd, v. 73, p. 1-7, 2017.0167-4943http://hdl.handle.net/11449/16339810.1016/j.archger.2017.07.002WOS:000413123600001WOS000413123600001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives Of Gerontology And Geriatrics1,010info:eu-repo/semantics/openAccess2024-08-14T17:23:09Zoai:repositorio.unesp.br:11449/163398Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome |
title |
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome |
spellingShingle |
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome Shigaeff, Nadia Metabolic syndrome Elderly Biomarker Neuropsychological assessment Cognitive impairment Functional magnetic resonance |
title_short |
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome |
title_full |
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome |
title_fullStr |
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome |
title_full_unstemmed |
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome |
title_sort |
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome |
author |
Shigaeff, Nadia |
author_facet |
Shigaeff, Nadia Amaro, Edson Franco, Fabio G. M. Jacinto, Alessandro F. [UNESP] Chiochetta, Gabriela Cendoroglo, Maysa S. Citero, Vanessa A. |
author_role |
author |
author2 |
Amaro, Edson Franco, Fabio G. M. Jacinto, Alessandro F. [UNESP] Chiochetta, Gabriela Cendoroglo, Maysa S. Citero, Vanessa A. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Hosp Israelita Albert Einstein Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Shigaeff, Nadia Amaro, Edson Franco, Fabio G. M. Jacinto, Alessandro F. [UNESP] Chiochetta, Gabriela Cendoroglo, Maysa S. Citero, Vanessa A. |
dc.subject.por.fl_str_mv |
Metabolic syndrome Elderly Biomarker Neuropsychological assessment Cognitive impairment Functional magnetic resonance |
topic |
Metabolic syndrome Elderly Biomarker Neuropsychological assessment Cognitive impairment Functional magnetic resonance |
description |
Objectives: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated with cognitive decline in executive function in the short-term. Method: We analyzed 43 individuals (23 MetS, 20 controls) using a global geriatric evaluation, a neuropsychological battery, and task-related (attention) fMRI exam. Correlation analysis between the fMRI signal at baseline and cognitive impairment after 1 year was based on the voxel-based Pearson coefficient, corrected for multiple comparisons. Results: At baseline, MetS patients showed reduced brain response in frontal and parietal regions compared to controls. After one year, the MetS group also showed a decline in verbal fluency performance. fMRI response in the right dorsolateral prefrontal cortex and bilateral parietal lobes was negatively correlated with verbal fluency decline in the MetS group. Discussion: Our results provide an early biomarker of the possible development of cognitive impairment, particularly in the executive function, of elderly individuals suffering from MetS. These findings also point to an up or down regulation which could be interpreted as compensatory mechanism for possible brain tissue burden caused by MetS. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-01 2018-11-26T17:41:51Z 2018-11-26T17:41:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.archger.2017.07.002 Archives Of Gerontology And Geriatrics. Clare: Elsevier Ireland Ltd, v. 73, p. 1-7, 2017. 0167-4943 http://hdl.handle.net/11449/163398 10.1016/j.archger.2017.07.002 WOS:000413123600001 WOS000413123600001.pdf |
url |
http://dx.doi.org/10.1016/j.archger.2017.07.002 http://hdl.handle.net/11449/163398 |
identifier_str_mv |
Archives Of Gerontology And Geriatrics. Clare: Elsevier Ireland Ltd, v. 73, p. 1-7, 2017. 0167-4943 10.1016/j.archger.2017.07.002 WOS:000413123600001 WOS000413123600001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives Of Gerontology And Geriatrics 1,010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-7 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128149446197248 |