Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis

Detalhes bibliográficos
Autor(a) principal: Nasser, Ana Lucia Martiniano [UNESP]
Data de Publicação: 2013
Outros Autores: Pavan, Fernando Rogério [UNESP], Boralle, Nivaldo [UNESP], Zocolo, Guilherme Julião [UNESP], Dos Santos, Lourdes Campaner [UNESP], de Marchi, Mary Rosa Rodrigues [UNESP], Leite, Clarice Queico Fujimura [UNESP], Vilegas, Wagner [UNESP]
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/232273
Resumo: The chloroform extract of bark of the tropical tree Qualea parviflora (Vochysiaceae) was fractionated by column chromatography on silica gel, yielding triterpenes (lupeol, lupenone, betulin, epi-betulinic acid and friedelin) and a steroid (β-sitosterol). β-sitosterol, lupenone and lupeol were also identified in Q. grandiflora and Q. multiflora, while friedelin was detected only in Q. Multiflora, by means of gas chromatography-mass spectrometry. The anti-Mycobacterium tuberculosis activity of the chloroform extract and isolated compounds was assayed by MABA and MIC values ranged from 250.0 to 31.2 μg/mL. This study is the first to investigate the chemistry and antitubercular activity of apolar compounds from Qualea species.
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spelling Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosisSterol and triterpenes from qualea species: Bioactivity on mycobacterium tuberculosisAnti-mycobacterium tuberculosis activityQualea speciesTriterpenesThe chloroform extract of bark of the tropical tree Qualea parviflora (Vochysiaceae) was fractionated by column chromatography on silica gel, yielding triterpenes (lupeol, lupenone, betulin, epi-betulinic acid and friedelin) and a steroid (β-sitosterol). β-sitosterol, lupenone and lupeol were also identified in Q. grandiflora and Q. multiflora, while friedelin was detected only in Q. Multiflora, by means of gas chromatography-mass spectrometry. The anti-Mycobacterium tuberculosis activity of the chloroform extract and isolated compounds was assayed by MABA and MIC values ranged from 250.0 to 31.2 μg/mL. This study is the first to investigate the chemistry and antitubercular activity of apolar compounds from Qualea species.Instituto de Química, UNESP, Araraquara, São PauloUNESP, Araraquara, São PauloInstituto de Química, UNESP, Araraquara, São PauloUNESP, Araraquara, São PauloUniversidade Estadual Paulista (UNESP)Nasser, Ana Lucia Martiniano [UNESP]Pavan, Fernando Rogério [UNESP]Boralle, Nivaldo [UNESP]Zocolo, Guilherme Julião [UNESP]Dos Santos, Lourdes Campaner [UNESP]de Marchi, Mary Rosa Rodrigues [UNESP]Leite, Clarice Queico Fujimura [UNESP]Vilegas, Wagner [UNESP]2022-04-29T09:35:28Z2022-04-29T09:35:28Z2013-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article513-517Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 34, n. 4, p. 513-517, 2013.1808-4532http://hdl.handle.net/11449/2322732-s2.0-84898659908Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporRevista de Ciencias Farmaceuticas Basica e Aplicadainfo:eu-repo/semantics/openAccess2024-06-24T13:07:38Zoai:repositorio.unesp.br:11449/232273Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:51:51.296661Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
Sterol and triterpenes from qualea species: Bioactivity on mycobacterium tuberculosis
title Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
spellingShingle Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
Nasser, Ana Lucia Martiniano [UNESP]
Anti-mycobacterium tuberculosis activity
Qualea species
Triterpenes
title_short Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
title_full Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
title_fullStr Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
title_full_unstemmed Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
title_sort Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
author Nasser, Ana Lucia Martiniano [UNESP]
author_facet Nasser, Ana Lucia Martiniano [UNESP]
Pavan, Fernando Rogério [UNESP]
Boralle, Nivaldo [UNESP]
Zocolo, Guilherme Julião [UNESP]
Dos Santos, Lourdes Campaner [UNESP]
de Marchi, Mary Rosa Rodrigues [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Vilegas, Wagner [UNESP]
author_role author
author2 Pavan, Fernando Rogério [UNESP]
Boralle, Nivaldo [UNESP]
Zocolo, Guilherme Julião [UNESP]
Dos Santos, Lourdes Campaner [UNESP]
de Marchi, Mary Rosa Rodrigues [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Vilegas, Wagner [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Nasser, Ana Lucia Martiniano [UNESP]
Pavan, Fernando Rogério [UNESP]
Boralle, Nivaldo [UNESP]
Zocolo, Guilherme Julião [UNESP]
Dos Santos, Lourdes Campaner [UNESP]
de Marchi, Mary Rosa Rodrigues [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Vilegas, Wagner [UNESP]
dc.subject.por.fl_str_mv Anti-mycobacterium tuberculosis activity
Qualea species
Triterpenes
topic Anti-mycobacterium tuberculosis activity
Qualea species
Triterpenes
description The chloroform extract of bark of the tropical tree Qualea parviflora (Vochysiaceae) was fractionated by column chromatography on silica gel, yielding triterpenes (lupeol, lupenone, betulin, epi-betulinic acid and friedelin) and a steroid (β-sitosterol). β-sitosterol, lupenone and lupeol were also identified in Q. grandiflora and Q. multiflora, while friedelin was detected only in Q. Multiflora, by means of gas chromatography-mass spectrometry. The anti-Mycobacterium tuberculosis activity of the chloroform extract and isolated compounds was assayed by MABA and MIC values ranged from 250.0 to 31.2 μg/mL. This study is the first to investigate the chemistry and antitubercular activity of apolar compounds from Qualea species.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2022-04-29T09:35:28Z
2022-04-29T09:35:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 34, n. 4, p. 513-517, 2013.
1808-4532
http://hdl.handle.net/11449/232273
2-s2.0-84898659908
identifier_str_mv Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 34, n. 4, p. 513-517, 2013.
1808-4532
2-s2.0-84898659908
url http://hdl.handle.net/11449/232273
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv Revista de Ciencias Farmaceuticas Basica e Aplicada
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 513-517
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128867775283200

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