Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1984-29612014004 http://hdl.handle.net/11449/113222 |
Resumo: | The objective of this study was to analyze morphological changes and parasite loads in the adrenal gland from 45 dogs with visceral leishmaniasis (VL). The animals were from the Zoonosis Control Center of Aracatuba, state of Sao Paulo, which is an endemic region for the disease. These animals were euthanized due to positive diagnoses of VL. The dogs were classified into asymptomatic, oligosymptomatic and symptomatic groups. The parasite load was determined by immunohistochemistry, using VL-positive dog hyperimmune serum. Nine dogs showed an inflammatory infiltrate composed, predominantly, of plasma cells and macrophages. However, only eight dogs showed macrophages with amastigote forms of the parasite, immunolabeled in the cytoplasm. The medullary and reticular layers were the most affected areas, possibly due to a favorable microenvironment created by hormones in these regions. The density of parasites in the glandular tissue was not associated with clinical signs of VL (P > 0.05). However, the presence of the parasite was always associated with the presence of a granulomatous inflammatory infiltrate. This gland may not be an ideal place for the parasite's multiplication, but the presence of injuries to the glandular tissue could influence the dog's immune system, thus favoring the parasite's survival in the host's different organs. |
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Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasisLeishmania infantum chagasiadrenalitisDogImmunohistochemistryThe objective of this study was to analyze morphological changes and parasite loads in the adrenal gland from 45 dogs with visceral leishmaniasis (VL). The animals were from the Zoonosis Control Center of Aracatuba, state of Sao Paulo, which is an endemic region for the disease. These animals were euthanized due to positive diagnoses of VL. The dogs were classified into asymptomatic, oligosymptomatic and symptomatic groups. The parasite load was determined by immunohistochemistry, using VL-positive dog hyperimmune serum. Nine dogs showed an inflammatory infiltrate composed, predominantly, of plasma cells and macrophages. However, only eight dogs showed macrophages with amastigote forms of the parasite, immunolabeled in the cytoplasm. The medullary and reticular layers were the most affected areas, possibly due to a favorable microenvironment created by hormones in these regions. The density of parasites in the glandular tissue was not associated with clinical signs of VL (P > 0.05). However, the presence of the parasite was always associated with the presence of a granulomatous inflammatory infiltrate. This gland may not be an ideal place for the parasite's multiplication, but the presence of injuries to the glandular tissue could influence the dog's immune system, thus favoring the parasite's survival in the host's different organs.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, FCAV, Dept Patol Vet, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, FMVA, Dept Apoio Prod & Saude Anim, Aracatuba, SP, BrazilUniv Estadual Paulista, FCAV, Dept Ciencias Exatas, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, FCAV, Dept Patol Vet, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, FMVA, Dept Apoio Prod & Saude Anim, Aracatuba, SP, BrazilUniv Estadual Paulista, FCAV, Dept Ciencias Exatas, BR-14884900 Jaboticabal, SP, BrazilFAPESP: 09/07815-4FAPESP: 09/15736-7FAPESP: 07/01457-3Brazilian Coll Veterinary ParasitologyUniversidade Estadual Paulista (Unesp)Momo, Claudia [UNESP]Souza Rocha, Nathalia Alves de [UNESP]Reina Moreira, Pamela Rodrigues [UNESP]Munari, Danisio Prado [UNESP]Mogami Bomfim, Suely Regina [UNESP]Rozza, Daniela Bernadete [UNESP]Vasconcelos, Rosemeri de Oliveira [UNESP]2014-12-03T13:11:31Z2014-12-03T13:11:31Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article30-35application/pdfhttp://dx.doi.org/10.1590/S1984-29612014004Revista Brasileira de Parasitologia Veterinaria. São Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 1, p. 30-35, 2014.1984-2961http://hdl.handle.net/11449/113222S1984-29612014000100005WOS:000336615000005S1984-29612014000100005.pdf426588815367452060642777319032499625372096858183Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Parasitologia Veterinária1.090info:eu-repo/semantics/openAccess2024-09-04T19:15:12Zoai:repositorio.unesp.br:11449/113222Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:15:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis |
title |
Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis |
spellingShingle |
Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis Momo, Claudia [UNESP] Leishmania infantum chagasi adrenalitis Dog Immunohistochemistry |
title_short |
Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis |
title_full |
Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis |
title_fullStr |
Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis |
title_full_unstemmed |
Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis |
title_sort |
Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis |
author |
Momo, Claudia [UNESP] |
author_facet |
Momo, Claudia [UNESP] Souza Rocha, Nathalia Alves de [UNESP] Reina Moreira, Pamela Rodrigues [UNESP] Munari, Danisio Prado [UNESP] Mogami Bomfim, Suely Regina [UNESP] Rozza, Daniela Bernadete [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] |
author_role |
author |
author2 |
Souza Rocha, Nathalia Alves de [UNESP] Reina Moreira, Pamela Rodrigues [UNESP] Munari, Danisio Prado [UNESP] Mogami Bomfim, Suely Regina [UNESP] Rozza, Daniela Bernadete [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Momo, Claudia [UNESP] Souza Rocha, Nathalia Alves de [UNESP] Reina Moreira, Pamela Rodrigues [UNESP] Munari, Danisio Prado [UNESP] Mogami Bomfim, Suely Regina [UNESP] Rozza, Daniela Bernadete [UNESP] Vasconcelos, Rosemeri de Oliveira [UNESP] |
dc.subject.por.fl_str_mv |
Leishmania infantum chagasi adrenalitis Dog Immunohistochemistry |
topic |
Leishmania infantum chagasi adrenalitis Dog Immunohistochemistry |
description |
The objective of this study was to analyze morphological changes and parasite loads in the adrenal gland from 45 dogs with visceral leishmaniasis (VL). The animals were from the Zoonosis Control Center of Aracatuba, state of Sao Paulo, which is an endemic region for the disease. These animals were euthanized due to positive diagnoses of VL. The dogs were classified into asymptomatic, oligosymptomatic and symptomatic groups. The parasite load was determined by immunohistochemistry, using VL-positive dog hyperimmune serum. Nine dogs showed an inflammatory infiltrate composed, predominantly, of plasma cells and macrophages. However, only eight dogs showed macrophages with amastigote forms of the parasite, immunolabeled in the cytoplasm. The medullary and reticular layers were the most affected areas, possibly due to a favorable microenvironment created by hormones in these regions. The density of parasites in the glandular tissue was not associated with clinical signs of VL (P > 0.05). However, the presence of the parasite was always associated with the presence of a granulomatous inflammatory infiltrate. This gland may not be an ideal place for the parasite's multiplication, but the presence of injuries to the glandular tissue could influence the dog's immune system, thus favoring the parasite's survival in the host's different organs. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:11:31Z 2014-12-03T13:11:31Z 2014-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1984-29612014004 Revista Brasileira de Parasitologia Veterinaria. São Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 1, p. 30-35, 2014. 1984-2961 http://hdl.handle.net/11449/113222 S1984-29612014000100005 WOS:000336615000005 S1984-29612014000100005.pdf 4265888153674520 6064277731903249 9625372096858183 |
url |
http://dx.doi.org/10.1590/S1984-29612014004 http://hdl.handle.net/11449/113222 |
identifier_str_mv |
Revista Brasileira de Parasitologia Veterinaria. São Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 1, p. 30-35, 2014. 1984-2961 S1984-29612014000100005 WOS:000336615000005 S1984-29612014000100005.pdf 4265888153674520 6064277731903249 9625372096858183 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária 1.090 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
30-35 application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Coll Veterinary Parasitology |
publisher.none.fl_str_mv |
Brazilian Coll Veterinary Parasitology |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021374491623424 |