Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Momo, Claudia [UNESP]
Data de Publicação: 2014
Outros Autores: Souza Rocha, Nathalia Alves de [UNESP], Reina Moreira, Pamela Rodrigues [UNESP], Munari, Danisio Prado [UNESP], Mogami Bomfim, Suely Regina [UNESP], Rozza, Daniela Bernadete [UNESP], Vasconcelos, Rosemeri de Oliveira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1984-29612014004
http://hdl.handle.net/11449/113222
Resumo: The objective of this study was to analyze morphological changes and parasite loads in the adrenal gland from 45 dogs with visceral leishmaniasis (VL). The animals were from the Zoonosis Control Center of Aracatuba, state of Sao Paulo, which is an endemic region for the disease. These animals were euthanized due to positive diagnoses of VL. The dogs were classified into asymptomatic, oligosymptomatic and symptomatic groups. The parasite load was determined by immunohistochemistry, using VL-positive dog hyperimmune serum. Nine dogs showed an inflammatory infiltrate composed, predominantly, of plasma cells and macrophages. However, only eight dogs showed macrophages with amastigote forms of the parasite, immunolabeled in the cytoplasm. The medullary and reticular layers were the most affected areas, possibly due to a favorable microenvironment created by hormones in these regions. The density of parasites in the glandular tissue was not associated with clinical signs of VL (P > 0.05). However, the presence of the parasite was always associated with the presence of a granulomatous inflammatory infiltrate. This gland may not be an ideal place for the parasite's multiplication, but the presence of injuries to the glandular tissue could influence the dog's immune system, thus favoring the parasite's survival in the host's different organs.
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spelling Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasisLeishmania infantum chagasiadrenalitisDogImmunohistochemistryThe objective of this study was to analyze morphological changes and parasite loads in the adrenal gland from 45 dogs with visceral leishmaniasis (VL). The animals were from the Zoonosis Control Center of Aracatuba, state of Sao Paulo, which is an endemic region for the disease. These animals were euthanized due to positive diagnoses of VL. The dogs were classified into asymptomatic, oligosymptomatic and symptomatic groups. The parasite load was determined by immunohistochemistry, using VL-positive dog hyperimmune serum. Nine dogs showed an inflammatory infiltrate composed, predominantly, of plasma cells and macrophages. However, only eight dogs showed macrophages with amastigote forms of the parasite, immunolabeled in the cytoplasm. The medullary and reticular layers were the most affected areas, possibly due to a favorable microenvironment created by hormones in these regions. The density of parasites in the glandular tissue was not associated with clinical signs of VL (P > 0.05). However, the presence of the parasite was always associated with the presence of a granulomatous inflammatory infiltrate. This gland may not be an ideal place for the parasite's multiplication, but the presence of injuries to the glandular tissue could influence the dog's immune system, thus favoring the parasite's survival in the host's different organs.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, FCAV, Dept Patol Vet, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, FMVA, Dept Apoio Prod & Saude Anim, Aracatuba, SP, BrazilUniv Estadual Paulista, FCAV, Dept Ciencias Exatas, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, FCAV, Dept Patol Vet, BR-14884900 Jaboticabal, SP, BrazilUniv Estadual Paulista, FMVA, Dept Apoio Prod & Saude Anim, Aracatuba, SP, BrazilUniv Estadual Paulista, FCAV, Dept Ciencias Exatas, BR-14884900 Jaboticabal, SP, BrazilFAPESP: 09/07815-4FAPESP: 09/15736-7FAPESP: 07/01457-3Brazilian Coll Veterinary ParasitologyUniversidade Estadual Paulista (Unesp)Momo, Claudia [UNESP]Souza Rocha, Nathalia Alves de [UNESP]Reina Moreira, Pamela Rodrigues [UNESP]Munari, Danisio Prado [UNESP]Mogami Bomfim, Suely Regina [UNESP]Rozza, Daniela Bernadete [UNESP]Vasconcelos, Rosemeri de Oliveira [UNESP]2014-12-03T13:11:31Z2014-12-03T13:11:31Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article30-35application/pdfhttp://dx.doi.org/10.1590/S1984-29612014004Revista Brasileira de Parasitologia Veterinaria. São Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 1, p. 30-35, 2014.1984-2961http://hdl.handle.net/11449/113222S1984-29612014000100005WOS:000336615000005S1984-29612014000100005.pdf426588815367452060642777319032499625372096858183Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Parasitologia Veterinária1.090info:eu-repo/semantics/openAccess2024-09-04T19:15:12Zoai:repositorio.unesp.br:11449/113222Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:15:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
title Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
spellingShingle Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
Momo, Claudia [UNESP]
Leishmania infantum chagasi
adrenalitis
Dog
Immunohistochemistry
title_short Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
title_full Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
title_fullStr Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
title_full_unstemmed Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
title_sort Morphological changes and parasite load of the adrenal from dogs with visceral leishmaniasis
author Momo, Claudia [UNESP]
author_facet Momo, Claudia [UNESP]
Souza Rocha, Nathalia Alves de [UNESP]
Reina Moreira, Pamela Rodrigues [UNESP]
Munari, Danisio Prado [UNESP]
Mogami Bomfim, Suely Regina [UNESP]
Rozza, Daniela Bernadete [UNESP]
Vasconcelos, Rosemeri de Oliveira [UNESP]
author_role author
author2 Souza Rocha, Nathalia Alves de [UNESP]
Reina Moreira, Pamela Rodrigues [UNESP]
Munari, Danisio Prado [UNESP]
Mogami Bomfim, Suely Regina [UNESP]
Rozza, Daniela Bernadete [UNESP]
Vasconcelos, Rosemeri de Oliveira [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Momo, Claudia [UNESP]
Souza Rocha, Nathalia Alves de [UNESP]
Reina Moreira, Pamela Rodrigues [UNESP]
Munari, Danisio Prado [UNESP]
Mogami Bomfim, Suely Regina [UNESP]
Rozza, Daniela Bernadete [UNESP]
Vasconcelos, Rosemeri de Oliveira [UNESP]
dc.subject.por.fl_str_mv Leishmania infantum chagasi
adrenalitis
Dog
Immunohistochemistry
topic Leishmania infantum chagasi
adrenalitis
Dog
Immunohistochemistry
description The objective of this study was to analyze morphological changes and parasite loads in the adrenal gland from 45 dogs with visceral leishmaniasis (VL). The animals were from the Zoonosis Control Center of Aracatuba, state of Sao Paulo, which is an endemic region for the disease. These animals were euthanized due to positive diagnoses of VL. The dogs were classified into asymptomatic, oligosymptomatic and symptomatic groups. The parasite load was determined by immunohistochemistry, using VL-positive dog hyperimmune serum. Nine dogs showed an inflammatory infiltrate composed, predominantly, of plasma cells and macrophages. However, only eight dogs showed macrophages with amastigote forms of the parasite, immunolabeled in the cytoplasm. The medullary and reticular layers were the most affected areas, possibly due to a favorable microenvironment created by hormones in these regions. The density of parasites in the glandular tissue was not associated with clinical signs of VL (P > 0.05). However, the presence of the parasite was always associated with the presence of a granulomatous inflammatory infiltrate. This gland may not be an ideal place for the parasite's multiplication, but the presence of injuries to the glandular tissue could influence the dog's immune system, thus favoring the parasite's survival in the host's different organs.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-03T13:11:31Z
2014-12-03T13:11:31Z
2014-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1984-29612014004
Revista Brasileira de Parasitologia Veterinaria. São Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 1, p. 30-35, 2014.
1984-2961
http://hdl.handle.net/11449/113222
S1984-29612014000100005
WOS:000336615000005
S1984-29612014000100005.pdf
4265888153674520
6064277731903249
9625372096858183
url http://dx.doi.org/10.1590/S1984-29612014004
http://hdl.handle.net/11449/113222
identifier_str_mv Revista Brasileira de Parasitologia Veterinaria. São Paulo: Brazilian Coll Veterinary Parasitology, v. 23, n. 1, p. 30-35, 2014.
1984-2961
S1984-29612014000100005
WOS:000336615000005
S1984-29612014000100005.pdf
4265888153674520
6064277731903249
9625372096858183
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira de Parasitologia Veterinária
1.090
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 30-35
application/pdf
dc.publisher.none.fl_str_mv Brazilian Coll Veterinary Parasitology
publisher.none.fl_str_mv Brazilian Coll Veterinary Parasitology
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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