Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2147/IJGM.S326192 http://hdl.handle.net/11449/229770 |
Resumo: | Background and Aim: Long-term use of non-selective beta blockers (NSBBs) is essential for the prevention of esophageal variceal bleeding in liver cirrhosis but may impair the patient’s adherence. The present study aimed to investigate the adherence to NSBBs to prevent variceal bleeding in cirrhotic patients. Methods: All patients who had an indication of NSBBs for the prophylaxis of variceal bleeding between February 2018 and June 2019 were screened. Clinical pharmacists gave pre-medication education and recorded the adherence to NSBBs during the patients’ hospi-talizations. Factors associated with poor adherence were evaluated by univariate logistic regression analysis. Odds ratios (OR) with 95% confidence intervals (CI) were calculated. The relationship between poor adherence during follow-up and variceal bleeding after discharge was also evaluated. Results: Overall, 108 patients were screened, of whom 12 were intolerant to NSBBs. Among the 96 remaining patients who could take NSBBs, the average change of heart rate after NSBBs was −10.49 b.p.m. Twenty-two (22.9%) patients had poor adherence to NSBBs due to their refusal to take NSBBs (n = 2), complete forgetfulness to take NSBBs (n = 10), and refusal or forgetfulness to monitor heart rate (n = 10). Univariate logistic regression analysis demonstrated that only older age was significantly associated with poor adherence (OR: 1.065, 95% CI: 1.019–1.114, P = 0.005). Patients with poor adherence during follow-up were more likely to develop variceal bleeding after discharge. Conclusion: A significant proportion of cirrhotic patients had poor adherence to NSBBs during their hospitalizations. Further studies should explore how to improve the patient’s adherence to NSBBs. |
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Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patientsAdherenceEsophageal varicesLiver cirrhosisNon-selective beta blockersRisk factorsBackground and Aim: Long-term use of non-selective beta blockers (NSBBs) is essential for the prevention of esophageal variceal bleeding in liver cirrhosis but may impair the patient’s adherence. The present study aimed to investigate the adherence to NSBBs to prevent variceal bleeding in cirrhotic patients. Methods: All patients who had an indication of NSBBs for the prophylaxis of variceal bleeding between February 2018 and June 2019 were screened. Clinical pharmacists gave pre-medication education and recorded the adherence to NSBBs during the patients’ hospi-talizations. Factors associated with poor adherence were evaluated by univariate logistic regression analysis. Odds ratios (OR) with 95% confidence intervals (CI) were calculated. The relationship between poor adherence during follow-up and variceal bleeding after discharge was also evaluated. Results: Overall, 108 patients were screened, of whom 12 were intolerant to NSBBs. Among the 96 remaining patients who could take NSBBs, the average change of heart rate after NSBBs was −10.49 b.p.m. Twenty-two (22.9%) patients had poor adherence to NSBBs due to their refusal to take NSBBs (n = 2), complete forgetfulness to take NSBBs (n = 10), and refusal or forgetfulness to monitor heart rate (n = 10). Univariate logistic regression analysis demonstrated that only older age was significantly associated with poor adherence (OR: 1.065, 95% CI: 1.019–1.114, P = 0.005). Patients with poor adherence during follow-up were more likely to develop variceal bleeding after discharge. Conclusion: A significant proportion of cirrhotic patients had poor adherence to NSBBs during their hospitalizations. Further studies should explore how to improve the patient’s adherence to NSBBs.Liver Cirrhosis Study Group Department of Gastroenterology General Hospital of Northern Theater CommandPostgraduate College Shenyang Pharmaceutical UniversityDepartment of Pharmacy General Hospital of Northern Theater CommandSection of Medical Service General Hospital of Northern Theater CommandDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista, Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião JrMedicina Interna 1 ARNAS-Civico Di Cristina-BenfratelliDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista, Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião JrGeneral Hospital of Northern Theater CommandShenyang Pharmaceutical UniversityUniversidade Estadual Paulista (UNESP)Di Cristina-BenfratelliAn, YangXu, XiangboRen, TianshuTong, ZhenhuaRomeiro, Fernando Gomes [UNESP]Mancuso, AndreaGuo, XiaozhongQi, Xingshun2022-04-29T08:35:41Z2022-04-29T08:35:41Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6713-6724http://dx.doi.org/10.2147/IJGM.S326192International Journal of General Medicine, v. 14, p. 6713-6724.1178-7074http://hdl.handle.net/11449/22977010.2147/IJGM.S3261922-s2.0-85117717002Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of General Medicineinfo:eu-repo/semantics/openAccess2024-08-14T17:23:20Zoai:repositorio.unesp.br:11449/229770Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients |
title |
Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients |
spellingShingle |
Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients An, Yang Adherence Esophageal varices Liver cirrhosis Non-selective beta blockers Risk factors |
title_short |
Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients |
title_full |
Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients |
title_fullStr |
Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients |
title_full_unstemmed |
Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients |
title_sort |
Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients |
author |
An, Yang |
author_facet |
An, Yang Xu, Xiangbo Ren, Tianshu Tong, Zhenhua Romeiro, Fernando Gomes [UNESP] Mancuso, Andrea Guo, Xiaozhong Qi, Xingshun |
author_role |
author |
author2 |
Xu, Xiangbo Ren, Tianshu Tong, Zhenhua Romeiro, Fernando Gomes [UNESP] Mancuso, Andrea Guo, Xiaozhong Qi, Xingshun |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
General Hospital of Northern Theater Command Shenyang Pharmaceutical University Universidade Estadual Paulista (UNESP) Di Cristina-Benfratelli |
dc.contributor.author.fl_str_mv |
An, Yang Xu, Xiangbo Ren, Tianshu Tong, Zhenhua Romeiro, Fernando Gomes [UNESP] Mancuso, Andrea Guo, Xiaozhong Qi, Xingshun |
dc.subject.por.fl_str_mv |
Adherence Esophageal varices Liver cirrhosis Non-selective beta blockers Risk factors |
topic |
Adherence Esophageal varices Liver cirrhosis Non-selective beta blockers Risk factors |
description |
Background and Aim: Long-term use of non-selective beta blockers (NSBBs) is essential for the prevention of esophageal variceal bleeding in liver cirrhosis but may impair the patient’s adherence. The present study aimed to investigate the adherence to NSBBs to prevent variceal bleeding in cirrhotic patients. Methods: All patients who had an indication of NSBBs for the prophylaxis of variceal bleeding between February 2018 and June 2019 were screened. Clinical pharmacists gave pre-medication education and recorded the adherence to NSBBs during the patients’ hospi-talizations. Factors associated with poor adherence were evaluated by univariate logistic regression analysis. Odds ratios (OR) with 95% confidence intervals (CI) were calculated. The relationship between poor adherence during follow-up and variceal bleeding after discharge was also evaluated. Results: Overall, 108 patients were screened, of whom 12 were intolerant to NSBBs. Among the 96 remaining patients who could take NSBBs, the average change of heart rate after NSBBs was −10.49 b.p.m. Twenty-two (22.9%) patients had poor adherence to NSBBs due to their refusal to take NSBBs (n = 2), complete forgetfulness to take NSBBs (n = 10), and refusal or forgetfulness to monitor heart rate (n = 10). Univariate logistic regression analysis demonstrated that only older age was significantly associated with poor adherence (OR: 1.065, 95% CI: 1.019–1.114, P = 0.005). Patients with poor adherence during follow-up were more likely to develop variceal bleeding after discharge. Conclusion: A significant proportion of cirrhotic patients had poor adherence to NSBBs during their hospitalizations. Further studies should explore how to improve the patient’s adherence to NSBBs. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-29T08:35:41Z 2022-04-29T08:35:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2147/IJGM.S326192 International Journal of General Medicine, v. 14, p. 6713-6724. 1178-7074 http://hdl.handle.net/11449/229770 10.2147/IJGM.S326192 2-s2.0-85117717002 |
url |
http://dx.doi.org/10.2147/IJGM.S326192 http://hdl.handle.net/11449/229770 |
identifier_str_mv |
International Journal of General Medicine, v. 14, p. 6713-6724. 1178-7074 10.2147/IJGM.S326192 2-s2.0-85117717002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of General Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6713-6724 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128155373797376 |