Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p26-32 http://hdl.handle.net/11449/200932 |
Resumo: | Lipid-rich carcinoma of the mammary gland is a rare variant of cancer and extremely uncommon in dogs. This case report describes the clinical and histopathological aspects of lipid-rich carcinoma in a female dog. A four-year-old spaeyd German Shepherd dog with enlarged volume adhered to the caudal and inguinal abdominal mammary region was examined. The impossibility of surgical ressection led to euthanasia during the surgical procedure. At necropsy, analysis of the abdominal cavity revealed the presence of an irregularly shaped mass, whitish with red areas, in the intrapelvic region. Also, metastases in axillary and mediastinal lymph nodes and right lung were observed. Histopathological analysis of the tumor in the mammary glands and intrapelvic mass showed malignant neoplastic proliferation of epithelial cells. The cells had a distinct shape and boundary, a well-defined cytoplasm, and the presence of intracytoplasmic macro and micro vacuoles, which sometimes pushed the nuclei to the periphery. The lymph nodes had lost the histological architecture due to metastasis. Marked and diffuse immunostaining of tumor cells in the cytoplasm by pancytokeratin, GATA 3 and 35BH11 confirmed the epithelial origin of the tumor. This very aggressive and uncommon neoplasm should be considered as a possible metastasi in the differential diagnosis of tumors of the abdominal cavity. |
id |
UNSP_90c68904c0e0e55f2dcef4e5ebe4e846 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/200932 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavityCytokeratinHistologyImmunohistochemistryNecropsyLipid-rich carcinoma of the mammary gland is a rare variant of cancer and extremely uncommon in dogs. This case report describes the clinical and histopathological aspects of lipid-rich carcinoma in a female dog. A four-year-old spaeyd German Shepherd dog with enlarged volume adhered to the caudal and inguinal abdominal mammary region was examined. The impossibility of surgical ressection led to euthanasia during the surgical procedure. At necropsy, analysis of the abdominal cavity revealed the presence of an irregularly shaped mass, whitish with red areas, in the intrapelvic region. Also, metastases in axillary and mediastinal lymph nodes and right lung were observed. Histopathological analysis of the tumor in the mammary glands and intrapelvic mass showed malignant neoplastic proliferation of epithelial cells. The cells had a distinct shape and boundary, a well-defined cytoplasm, and the presence of intracytoplasmic macro and micro vacuoles, which sometimes pushed the nuclei to the periphery. The lymph nodes had lost the histological architecture due to metastasis. Marked and diffuse immunostaining of tumor cells in the cytoplasm by pancytokeratin, GATA 3 and 35BH11 confirmed the epithelial origin of the tumor. This very aggressive and uncommon neoplasm should be considered as a possible metastasi in the differential diagnosis of tumors of the abdominal cavity.Profissional Heath Program Resident Med. Vet. e Saúde (MEC/MS)Veterinary Pathology Departemnt-FCAV-UNESPVeterinary Clinic and Surgery Department FCAV-UNESPVeterinary Pathology Departemnt-FCAV-UNESPVeterinary Clinic and Surgery Department FCAV-UNESPProfissional Heath Program Resident Med. Vet. e Saúde (MEC/MS)Universidade Estadual Paulista (Unesp)Perossi, Isabela F. S.Martinelli, Paulo E. B.Bonato, LeticiaLima, Gabriela P. [UNESP]Bertolo, Paulo Henrique L. [UNESP]Costa, Rafael R. M. E. [UNESP]Gómez, Jorge L. A. [UNESP]De Nardi, Andrigo B. [UNESP]Vasconcelos, Rosemeri O. [UNESP]2020-12-12T02:19:51Z2020-12-12T02:19:51Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article26-32http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p26-32Brazilian Journal of Veterinary Pathology, v. 13, n. 1, p. 26-32, 2020.1983-0246http://hdl.handle.net/11449/20093210.24070/bjvp.1983-0246.v13i1p26-322-s2.0-85089713927Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Veterinary Pathologyinfo:eu-repo/semantics/openAccess2024-06-07T13:02:27Zoai:repositorio.unesp.br:11449/200932Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:25:54.134292Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity |
title |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity |
spellingShingle |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity Perossi, Isabela F. S. Cytokeratin Histology Immunohistochemistry Necropsy |
title_short |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity |
title_full |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity |
title_fullStr |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity |
title_full_unstemmed |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity |
title_sort |
Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity |
author |
Perossi, Isabela F. S. |
author_facet |
Perossi, Isabela F. S. Martinelli, Paulo E. B. Bonato, Leticia Lima, Gabriela P. [UNESP] Bertolo, Paulo Henrique L. [UNESP] Costa, Rafael R. M. E. [UNESP] Gómez, Jorge L. A. [UNESP] De Nardi, Andrigo B. [UNESP] Vasconcelos, Rosemeri O. [UNESP] |
author_role |
author |
author2 |
Martinelli, Paulo E. B. Bonato, Leticia Lima, Gabriela P. [UNESP] Bertolo, Paulo Henrique L. [UNESP] Costa, Rafael R. M. E. [UNESP] Gómez, Jorge L. A. [UNESP] De Nardi, Andrigo B. [UNESP] Vasconcelos, Rosemeri O. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Profissional Heath Program Resident Med. Vet. e Saúde (MEC/MS) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Perossi, Isabela F. S. Martinelli, Paulo E. B. Bonato, Leticia Lima, Gabriela P. [UNESP] Bertolo, Paulo Henrique L. [UNESP] Costa, Rafael R. M. E. [UNESP] Gómez, Jorge L. A. [UNESP] De Nardi, Andrigo B. [UNESP] Vasconcelos, Rosemeri O. [UNESP] |
dc.subject.por.fl_str_mv |
Cytokeratin Histology Immunohistochemistry Necropsy |
topic |
Cytokeratin Histology Immunohistochemistry Necropsy |
description |
Lipid-rich carcinoma of the mammary gland is a rare variant of cancer and extremely uncommon in dogs. This case report describes the clinical and histopathological aspects of lipid-rich carcinoma in a female dog. A four-year-old spaeyd German Shepherd dog with enlarged volume adhered to the caudal and inguinal abdominal mammary region was examined. The impossibility of surgical ressection led to euthanasia during the surgical procedure. At necropsy, analysis of the abdominal cavity revealed the presence of an irregularly shaped mass, whitish with red areas, in the intrapelvic region. Also, metastases in axillary and mediastinal lymph nodes and right lung were observed. Histopathological analysis of the tumor in the mammary glands and intrapelvic mass showed malignant neoplastic proliferation of epithelial cells. The cells had a distinct shape and boundary, a well-defined cytoplasm, and the presence of intracytoplasmic macro and micro vacuoles, which sometimes pushed the nuclei to the periphery. The lymph nodes had lost the histological architecture due to metastasis. Marked and diffuse immunostaining of tumor cells in the cytoplasm by pancytokeratin, GATA 3 and 35BH11 confirmed the epithelial origin of the tumor. This very aggressive and uncommon neoplasm should be considered as a possible metastasi in the differential diagnosis of tumors of the abdominal cavity. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:19:51Z 2020-12-12T02:19:51Z 2020-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p26-32 Brazilian Journal of Veterinary Pathology, v. 13, n. 1, p. 26-32, 2020. 1983-0246 http://hdl.handle.net/11449/200932 10.24070/bjvp.1983-0246.v13i1p26-32 2-s2.0-85089713927 |
url |
http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p26-32 http://hdl.handle.net/11449/200932 |
identifier_str_mv |
Brazilian Journal of Veterinary Pathology, v. 13, n. 1, p. 26-32, 2020. 1983-0246 10.24070/bjvp.1983-0246.v13i1p26-32 2-s2.0-85089713927 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Veterinary Pathology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
26-32 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129066957537280 |