Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1038/s41598-019-52498-7 http://hdl.handle.net/11449/201080 |
Resumo: | The objective of the present study was to establish if individuals with Diabetes Mellitus (DM2) and periodontal diseases (gingivitis or periodontitis) presented an increase in the concentration of modified LDL (moLDL) and what is the influence of periodontal treatment on the decrease of moLDL particles with consequent improvement in the parameters of DM2. Twenty-four diabetic patients with periodontitis (Group 1) and twenty-four diabetic patients with gingivitis (Group 2) were followed up for a period of 12 months. Group 1 was treated with periodontal debridement, and Group 2 received supra-gingival scaling and prophylaxis. In both groups, periodontal clinical parameters: probing depth (PD), clinical attachment level (CAL), gingival resection (GR), bleeding on probing index (BOP) and plaque index; inflammatory serum markers (glycemia, A1c, total cholesterol, HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c), triglycerides and hs-CRP) and oxidized LDL (oxLDL) were measured at baseline, t = 6 and t = 12 months after treatment. Solutions of LDL were analyzed using the nonlinear optical Z-Scan and optical absorption techniques. The periodontal clinical parameters showed significant improvement (p < 0.05) in both Group after 12 months. For both groups, total cholesterol, HDL-c, LDL-c, triglycerides and A1c levels did not show significant reductions after periodontal therapy. hs-CRP levels in Group 1 presented a significant reduction after 12 months. The glycemic rate and the oxLDL concentrations did not show significant differences as a function of time. The optical measurements of LDL solutions revealed an improvement of the LDL-c quality in both groups. Periodontal debridement was able to improve periodontal parameters and the quality of LDL-c in diabetic patients but without changes in the oxLDL concentration in both groups. Considering the clinical relevance, the reduction of infectious and inflammatory sites present in the oral cavity through periodontal therapy may help with the control and prevention of hyperglycemia and precursors of cardiovascular diseases. |
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Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patientsThe objective of the present study was to establish if individuals with Diabetes Mellitus (DM2) and periodontal diseases (gingivitis or periodontitis) presented an increase in the concentration of modified LDL (moLDL) and what is the influence of periodontal treatment on the decrease of moLDL particles with consequent improvement in the parameters of DM2. Twenty-four diabetic patients with periodontitis (Group 1) and twenty-four diabetic patients with gingivitis (Group 2) were followed up for a period of 12 months. Group 1 was treated with periodontal debridement, and Group 2 received supra-gingival scaling and prophylaxis. In both groups, periodontal clinical parameters: probing depth (PD), clinical attachment level (CAL), gingival resection (GR), bleeding on probing index (BOP) and plaque index; inflammatory serum markers (glycemia, A1c, total cholesterol, HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c), triglycerides and hs-CRP) and oxidized LDL (oxLDL) were measured at baseline, t = 6 and t = 12 months after treatment. Solutions of LDL were analyzed using the nonlinear optical Z-Scan and optical absorption techniques. The periodontal clinical parameters showed significant improvement (p < 0.05) in both Group after 12 months. For both groups, total cholesterol, HDL-c, LDL-c, triglycerides and A1c levels did not show significant reductions after periodontal therapy. hs-CRP levels in Group 1 presented a significant reduction after 12 months. The glycemic rate and the oxLDL concentrations did not show significant differences as a function of time. The optical measurements of LDL solutions revealed an improvement of the LDL-c quality in both groups. Periodontal debridement was able to improve periodontal parameters and the quality of LDL-c in diabetic patients but without changes in the oxLDL concentration in both groups. Considering the clinical relevance, the reduction of infectious and inflammatory sites present in the oral cavity through periodontal therapy may help with the control and prevention of hyperglycemia and precursors of cardiovascular diseases.São Paulo State University (UNESP) School of Sciences and Technology Department of Diagnosis and SurgeryUniversity of São Paulo (USP) Institute of PhysicsLabvi Valle Technique manageressUniversity of São Paulo Institute of Biomedical Science Department of ImmunologySão Paulo State University (UNESP) School of Sciences and Technology Department of Diagnosis and SurgeryUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Technique manageressPedroso, Juliana de Fatima [UNESP]Lotfollahi, ZahraAlbattarni, GhadeerArrruda Schulz, MaiaraMonteiro, AndreaSehnem, Andre LuizGidlund, Magnus AkeFigueiredo Neto, Antonio MartinsJardini, Maria Aparecida Neves [UNESP]2020-12-12T02:23:36Z2020-12-12T02:23:36Z2019-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-019-52498-7Scientific Reports, v. 9, n. 1, 2019.2045-2322http://hdl.handle.net/11449/20108010.1038/s41598-019-52498-72-s2.0-85074624271Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reportsinfo:eu-repo/semantics/openAccess2021-10-23T15:55:18Zoai:repositorio.unesp.br:11449/201080Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:39:47.489068Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients |
title |
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients |
spellingShingle |
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients Pedroso, Juliana de Fatima [UNESP] |
title_short |
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients |
title_full |
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients |
title_fullStr |
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients |
title_full_unstemmed |
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients |
title_sort |
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients |
author |
Pedroso, Juliana de Fatima [UNESP] |
author_facet |
Pedroso, Juliana de Fatima [UNESP] Lotfollahi, Zahra Albattarni, Ghadeer Arrruda Schulz, Maiara Monteiro, Andrea Sehnem, Andre Luiz Gidlund, Magnus Ake Figueiredo Neto, Antonio Martins Jardini, Maria Aparecida Neves [UNESP] |
author_role |
author |
author2 |
Lotfollahi, Zahra Albattarni, Ghadeer Arrruda Schulz, Maiara Monteiro, Andrea Sehnem, Andre Luiz Gidlund, Magnus Ake Figueiredo Neto, Antonio Martins Jardini, Maria Aparecida Neves [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Technique manageress |
dc.contributor.author.fl_str_mv |
Pedroso, Juliana de Fatima [UNESP] Lotfollahi, Zahra Albattarni, Ghadeer Arrruda Schulz, Maiara Monteiro, Andrea Sehnem, Andre Luiz Gidlund, Magnus Ake Figueiredo Neto, Antonio Martins Jardini, Maria Aparecida Neves [UNESP] |
description |
The objective of the present study was to establish if individuals with Diabetes Mellitus (DM2) and periodontal diseases (gingivitis or periodontitis) presented an increase in the concentration of modified LDL (moLDL) and what is the influence of periodontal treatment on the decrease of moLDL particles with consequent improvement in the parameters of DM2. Twenty-four diabetic patients with periodontitis (Group 1) and twenty-four diabetic patients with gingivitis (Group 2) were followed up for a period of 12 months. Group 1 was treated with periodontal debridement, and Group 2 received supra-gingival scaling and prophylaxis. In both groups, periodontal clinical parameters: probing depth (PD), clinical attachment level (CAL), gingival resection (GR), bleeding on probing index (BOP) and plaque index; inflammatory serum markers (glycemia, A1c, total cholesterol, HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c), triglycerides and hs-CRP) and oxidized LDL (oxLDL) were measured at baseline, t = 6 and t = 12 months after treatment. Solutions of LDL were analyzed using the nonlinear optical Z-Scan and optical absorption techniques. The periodontal clinical parameters showed significant improvement (p < 0.05) in both Group after 12 months. For both groups, total cholesterol, HDL-c, LDL-c, triglycerides and A1c levels did not show significant reductions after periodontal therapy. hs-CRP levels in Group 1 presented a significant reduction after 12 months. The glycemic rate and the oxLDL concentrations did not show significant differences as a function of time. The optical measurements of LDL solutions revealed an improvement of the LDL-c quality in both groups. Periodontal debridement was able to improve periodontal parameters and the quality of LDL-c in diabetic patients but without changes in the oxLDL concentration in both groups. Considering the clinical relevance, the reduction of infectious and inflammatory sites present in the oral cavity through periodontal therapy may help with the control and prevention of hyperglycemia and precursors of cardiovascular diseases. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 2020-12-12T02:23:36Z 2020-12-12T02:23:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-019-52498-7 Scientific Reports, v. 9, n. 1, 2019. 2045-2322 http://hdl.handle.net/11449/201080 10.1038/s41598-019-52498-7 2-s2.0-85074624271 |
url |
http://dx.doi.org/10.1038/s41598-019-52498-7 http://hdl.handle.net/11449/201080 |
identifier_str_mv |
Scientific Reports, v. 9, n. 1, 2019. 2045-2322 10.1038/s41598-019-52498-7 2-s2.0-85074624271 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128397281329152 |