Avaliação da infusão contínua de lidocaína em equinos submetidos à distensão ileal

• Autor(a) principal: Sartori, Vitor Cibiac [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/121936
• topic: Equino; Analgesia; Lidocaina; Intestinos; Dor; Intestines

Lidocaine administration is indicated for horses with colic due to its anti-inflammatory, analgesic and prokinetic effects. The aim of this study was to evaluate the systemic lidocaine administration on intestinal wall compliance, motility and the cardiorespiratory parameters in seven horses. Animals were divided in two groups, in a double-blinded study, with a wash out period of 15 days in between treatments. The lidocaine group (LG) received a bolus of 1.3 mg/kg (IV) over five minutes, followed by a constant rate infusion of 0.05 mg/kg/h during 60 minutes. The control group (CG) received the same volume of saline that animals from LG were treated. Thirty days before the study, animals were submitted to a typhlostomy. At the day of the study, intraluminal ileum distension was performed using a balloon with animals under quadrupedal position. Signs of abdominal pain and cardiorespiratory parameters were evaluated for 90 minutes, and intestinal motility and lidocaine plasma concentration for 720 minutes. Intestinal complacence was evaluated by the pressure of the balloon during 60 minutes or until two signs of abdominal discomfort were observed. Heart rate, rectal temperature, height of the head, intestinal motility and pressure of the balloon were not different between LG and CG. Arterial blood pressure increased after two minutes and decreased after 90 minutes of evaluation. Respiratory rate reduced after 60 minutes for the LG, however, for the CG this parameter increased after two and four minutes of evaluation. The experimental model for intestinal distension was trustful and is potentially replicable. Lidocaine administration did not influence the cardiorespiratory parameters and the intestinal complacence evaluated using the pressure of the balloon in the equine ileus