Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/S1734-1140(12)70732-6 http://hdl.handle.net/11449/219805 |
Resumo: | Caffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects. Copyright © 2012 by Institute of Pharmacology Polish Academy of Sciences. |
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Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental contextCaffeineEnvironmental contextPsychostimulantsSensitizationToleranceCaffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects. Copyright © 2012 by Institute of Pharmacology Polish Academy of Sciences.Laboratory of Pharmacology School of Pharmaceutical Sciences Univ. Estadual Paulista-UNESP, Rod. Araraquara-Jaú Km 1, 14801-902, Araraquara, SPInterinstitutional Graduate Program in Physiological Sciences UFSCar/UNESP, Rod. Washington Luiz Km 235, 13565-905, São Carlos, SPInstitute of Biomedical Sciences Federal University of Uberlândia (UFU), Av. Pará 1720, 38400-902, Uberlândia, MGLaboratory of Pharmacology School of Pharmaceutical Sciences Univ. Estadual Paulista-UNESP, Rod. Araraquara-Jaú Km 1, 14801-902, Araraquara, SPInterinstitutional Graduate Program in Physiological Sciences UFSCar/UNESP, Rod. Washington Luiz Km 235, 13565-905, São Carlos, SPUniversidade Estadual Paulista (UNESP)Universidade Federal de Uberlândia (UFU)Zancheta, Roberta [UNESP]Possi, Ana P. M. [UNESP]Planeta, Cleopatra S. [UNESP]Marin, Marcelo T. [UNESP]2022-04-28T18:57:40Z2022-04-28T18:57:40Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article70-77http://dx.doi.org/10.1016/S1734-1140(12)70732-6Pharmacological Reports, v. 64, n. 1, p. 70-77, 2012.1734-1140http://hdl.handle.net/11449/21980510.1016/S1734-1140(12)70732-62-s2.0-84862226918Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmacological Reportsinfo:eu-repo/semantics/openAccess2022-04-28T18:57:40Zoai:repositorio.unesp.br:11449/219805Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:24:35.193697Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
spellingShingle |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context Zancheta, Roberta [UNESP] Caffeine Environmental context Psychostimulants Sensitization Tolerance |
title_short |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title_full |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title_fullStr |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title_full_unstemmed |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title_sort |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
author |
Zancheta, Roberta [UNESP] |
author_facet |
Zancheta, Roberta [UNESP] Possi, Ana P. M. [UNESP] Planeta, Cleopatra S. [UNESP] Marin, Marcelo T. [UNESP] |
author_role |
author |
author2 |
Possi, Ana P. M. [UNESP] Planeta, Cleopatra S. [UNESP] Marin, Marcelo T. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Federal de Uberlândia (UFU) |
dc.contributor.author.fl_str_mv |
Zancheta, Roberta [UNESP] Possi, Ana P. M. [UNESP] Planeta, Cleopatra S. [UNESP] Marin, Marcelo T. [UNESP] |
dc.subject.por.fl_str_mv |
Caffeine Environmental context Psychostimulants Sensitization Tolerance |
topic |
Caffeine Environmental context Psychostimulants Sensitization Tolerance |
description |
Caffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects. Copyright © 2012 by Institute of Pharmacology Polish Academy of Sciences. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2022-04-28T18:57:40Z 2022-04-28T18:57:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/S1734-1140(12)70732-6 Pharmacological Reports, v. 64, n. 1, p. 70-77, 2012. 1734-1140 http://hdl.handle.net/11449/219805 10.1016/S1734-1140(12)70732-6 2-s2.0-84862226918 |
url |
http://dx.doi.org/10.1016/S1734-1140(12)70732-6 http://hdl.handle.net/11449/219805 |
identifier_str_mv |
Pharmacological Reports, v. 64, n. 1, p. 70-77, 2012. 1734-1140 10.1016/S1734-1140(12)70732-6 2-s2.0-84862226918 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmacological Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
70-77 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128510626103296 |