Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0001-3765202220211021 http://hdl.handle.net/11449/240984 |
Resumo: | This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast. |
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Repositório Institucional da UNESP |
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Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformansCapsuleCryptococcus neoformansDuloxetine hydrochlorideFluconazoleSynergistic combinationThis study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.Universidade Estadual Paulista (UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Oral, Av Engenheiro Francisco José Longo 777 SPUniversidade de Guarulhos (UNG), Rua Engenheiro Prestes Maia 88 SPUniversidade Estadual Paulista (UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Oral, Av Engenheiro Francisco José Longo 777 SPUniversidade Estadual Paulista (UNESP)Universidade de Guarulhos (UNG)Menezes, Raquel T. [UNESP]Pereira, Thaís C. [UNESP]Junqueira, Juliana C. [UNESP]Oliveira, Luciane D. [UNESP]Scorzoni, Liliawna [UNESP]2023-03-01T20:41:57Z2023-03-01T20:41:57Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/0001-3765202220211021Anais da Academia Brasileira de Ciencias, v. 94, n. 2, 2022.1678-26900001-3765http://hdl.handle.net/11449/24098410.1590/0001-37652022202110212-s2.0-85129974671Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Cienciasinfo:eu-repo/semantics/openAccess2023-03-01T20:41:58Zoai:repositorio.unesp.br:11449/240984Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:54:00.434550Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans |
title |
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans |
spellingShingle |
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans Menezes, Raquel T. [UNESP] Capsule Cryptococcus neoformans Duloxetine hydrochloride Fluconazole Synergistic combination |
title_short |
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans |
title_full |
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans |
title_fullStr |
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans |
title_full_unstemmed |
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans |
title_sort |
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans |
author |
Menezes, Raquel T. [UNESP] |
author_facet |
Menezes, Raquel T. [UNESP] Pereira, Thaís C. [UNESP] Junqueira, Juliana C. [UNESP] Oliveira, Luciane D. [UNESP] Scorzoni, Liliawna [UNESP] |
author_role |
author |
author2 |
Pereira, Thaís C. [UNESP] Junqueira, Juliana C. [UNESP] Oliveira, Luciane D. [UNESP] Scorzoni, Liliawna [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de Guarulhos (UNG) |
dc.contributor.author.fl_str_mv |
Menezes, Raquel T. [UNESP] Pereira, Thaís C. [UNESP] Junqueira, Juliana C. [UNESP] Oliveira, Luciane D. [UNESP] Scorzoni, Liliawna [UNESP] |
dc.subject.por.fl_str_mv |
Capsule Cryptococcus neoformans Duloxetine hydrochloride Fluconazole Synergistic combination |
topic |
Capsule Cryptococcus neoformans Duloxetine hydrochloride Fluconazole Synergistic combination |
description |
This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:41:57Z 2023-03-01T20:41:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0001-3765202220211021 Anais da Academia Brasileira de Ciencias, v. 94, n. 2, 2022. 1678-2690 0001-3765 http://hdl.handle.net/11449/240984 10.1590/0001-3765202220211021 2-s2.0-85129974671 |
url |
http://dx.doi.org/10.1590/0001-3765202220211021 http://hdl.handle.net/11449/240984 |
identifier_str_mv |
Anais da Academia Brasileira de Ciencias, v. 94, n. 2, 2022. 1678-2690 0001-3765 10.1590/0001-3765202220211021 2-s2.0-85129974671 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais da Academia Brasileira de Ciencias |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129371831009280 |