Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans

Detalhes bibliográficos
Autor(a) principal: Menezes, Raquel T. [UNESP]
Data de Publicação: 2022
Outros Autores: Pereira, Thaís C. [UNESP], Junqueira, Juliana C. [UNESP], Oliveira, Luciane D. [UNESP], Scorzoni, Liliawna [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/0001-3765202220211021
http://hdl.handle.net/11449/240984
Resumo: This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.
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spelling Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformansCapsuleCryptococcus neoformansDuloxetine hydrochlorideFluconazoleSynergistic combinationThis study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.Universidade Estadual Paulista (UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Oral, Av Engenheiro Francisco José Longo 777 SPUniversidade de Guarulhos (UNG), Rua Engenheiro Prestes Maia 88 SPUniversidade Estadual Paulista (UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Oral, Av Engenheiro Francisco José Longo 777 SPUniversidade Estadual Paulista (UNESP)Universidade de Guarulhos (UNG)Menezes, Raquel T. [UNESP]Pereira, Thaís C. [UNESP]Junqueira, Juliana C. [UNESP]Oliveira, Luciane D. [UNESP]Scorzoni, Liliawna [UNESP]2023-03-01T20:41:57Z2023-03-01T20:41:57Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/0001-3765202220211021Anais da Academia Brasileira de Ciencias, v. 94, n. 2, 2022.1678-26900001-3765http://hdl.handle.net/11449/24098410.1590/0001-37652022202110212-s2.0-85129974671Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Cienciasinfo:eu-repo/semantics/openAccess2023-03-01T20:41:58Zoai:repositorio.unesp.br:11449/240984Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T20:41:58Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
spellingShingle Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
Menezes, Raquel T. [UNESP]
Capsule
Cryptococcus neoformans
Duloxetine hydrochloride
Fluconazole
Synergistic combination
title_short Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title_full Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title_fullStr Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title_full_unstemmed Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title_sort Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
author Menezes, Raquel T. [UNESP]
author_facet Menezes, Raquel T. [UNESP]
Pereira, Thaís C. [UNESP]
Junqueira, Juliana C. [UNESP]
Oliveira, Luciane D. [UNESP]
Scorzoni, Liliawna [UNESP]
author_role author
author2 Pereira, Thaís C. [UNESP]
Junqueira, Juliana C. [UNESP]
Oliveira, Luciane D. [UNESP]
Scorzoni, Liliawna [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de Guarulhos (UNG)
dc.contributor.author.fl_str_mv Menezes, Raquel T. [UNESP]
Pereira, Thaís C. [UNESP]
Junqueira, Juliana C. [UNESP]
Oliveira, Luciane D. [UNESP]
Scorzoni, Liliawna [UNESP]
dc.subject.por.fl_str_mv Capsule
Cryptococcus neoformans
Duloxetine hydrochloride
Fluconazole
Synergistic combination
topic Capsule
Cryptococcus neoformans
Duloxetine hydrochloride
Fluconazole
Synergistic combination
description This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T20:41:57Z
2023-03-01T20:41:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0001-3765202220211021
Anais da Academia Brasileira de Ciencias, v. 94, n. 2, 2022.
1678-2690
0001-3765
http://hdl.handle.net/11449/240984
10.1590/0001-3765202220211021
2-s2.0-85129974671
url http://dx.doi.org/10.1590/0001-3765202220211021
http://hdl.handle.net/11449/240984
identifier_str_mv Anais da Academia Brasileira de Ciencias, v. 94, n. 2, 2022.
1678-2690
0001-3765
10.1590/0001-3765202220211021
2-s2.0-85129974671
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais da Academia Brasileira de Ciencias
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965485355237376

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