Características morfológicas cardíacas de ratas ovariectomizadas submetidas ao treinamento físico

• Autor(a) principal: Silva, Mariana Garcia Ferreira [UNESP]
• Data de Publicação: 2017
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/156211; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2018-02-22/000892183.pdf
• topic: Medicina esportiva; Anatomia comparada; Morfologia (Biologia); Ratos; Ovariectomia; Exercícios físicos; Coração; Celulas musculares

Cardiomyocites presents secretory aparatus close to the nucleum. There are many granules in the left atrium that stored atrial natriuretics peptides (ANP), a hormone capable of regulate blood pressure. The ovariectomy is a bilateral ovary removal that reduces production of ovaries hormones. This surgery can change ultraestructural caracteristics of cardiomyocites. Physical exercises can cause an atrial expansion because of blood flow increase, which is the major factor of stimulation and secretion of ANP. However, a few studies analyzes cardiac morphological changes in ovariectomized rats submitted at physical exercises. The aim of the study is to analyze morfological cardiac characteristics of ovariectomized Wistar rats submitted to swimming practice using light microscopy (LM), scanning electron microscopy (SEM) and electronic transmission electron microscopy (TEM). Fourty female Wistar rats were hosted with water and food ad libitum at 23±2ºC. The animals were divided into 4 groups (n=10): Sedentary Group (SG); Exercised Group (EG); Ovariectomized Group (OG) and Ovariectomized and Exercised Group (OEG). Body mass was measured in 3 periods: before surgery (1), after surgery and before exercise (2) and after exercise (3). After, all animals were euthanized and hearts were collected to preparing for LM, SEM, TEM technique and morphometric measurement. The results showed expressive bodymass increase in OG, the cardiomyocytes in structural cellular compliance in LM as the three-dimensional, besides the diameter enlargement in EG. We conclued that female Wistar rats submitted to ovariectomy, physical exercise or both can alterate bodymass, cardiac morphology and cardiomyocites ultraestructural caracteristics. Besides, exercise increased ANP diameter and consequent availability in blood flow