In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay

Detalhes bibliográficos
Autor(a) principal: Pugliesi, Gustavo de Carvalho
Data de Publicação: 2007
Outros Autores: De Andrade, Sérgio Faloni, Bastos, Jairo Kenupp, Maistro, Edson Luis [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1508/cytologia.72.1
http://hdl.handle.net/11449/69543
Resumo: The clastogenic effect of the A. populnea leaves extract was tested in vivo on bone marrow cells of Wistar rats by evaluating the induction of chromosome aberrations and micronuclei induction on polychromatic erythrocytes. The extract was administered by gavage at doses of 300, 600 and 900mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment. Under the conditions used, A. populnea leaves extract did not induce decrease in mitotic index and did not induce a statistically significant increase in the mean number of micronucleated polychromatic erythrocytes or chromosome aberrations in the bone marrow cells of Wistar rats. © 2007 The Japan Mendel Society.
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spelling In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assayAustroplenckia populneaCelastraceaeChromosome aberrationsMicronucleus testAnimaliaRattus norvegicusThe clastogenic effect of the A. populnea leaves extract was tested in vivo on bone marrow cells of Wistar rats by evaluating the induction of chromosome aberrations and micronuclei induction on polychromatic erythrocytes. The extract was administered by gavage at doses of 300, 600 and 900mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment. Under the conditions used, A. populnea leaves extract did not induce decrease in mitotic index and did not induce a statistically significant increase in the mean number of micronucleated polychromatic erythrocytes or chromosome aberrations in the bone marrow cells of Wistar rats. © 2007 The Japan Mendel Society.Instituto de Farmácia e Nutrição Lab. Genética UNIFENAS, 37130-000, Alfenas, MGUniversidade do Oeste de Santa Catarina Campus de Videira, SCLaboratório de Farmacognosia Departamento de Ciências Farmacêuticas USP, Ribeirão Preto, SPUniversidade de Estadual Paulista-UNESP Faculdade de Filosofia e Ciências Departamento de Fonoaudíologia, Marlia, SP 17525-900Universidade de Estadual Paulista-UNESP Faculdade de Filosofia e Ciências Departamento de Fonoaudíologia, Marlia, SP 17525-900UNIFENASUniversidade do Oeste de Santa CatarinaUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Pugliesi, Gustavo de CarvalhoDe Andrade, Sérgio FaloniBastos, Jairo KenuppMaistro, Edson Luis [UNESP]2014-05-27T11:22:25Z2014-05-27T11:22:25Z2007-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-6application/pdfhttp://dx.doi.org/10.1508/cytologia.72.1Cytologia, v. 72, n. 1, p. 1-6, 2007.0011-4545http://hdl.handle.net/11449/6954310.1508/cytologia.72.12-s2.0-342486431722-s2.0-34248643172.pdf47875216130383150000-0003-0757-7876Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCytologia0.4810,233info:eu-repo/semantics/openAccess2024-08-09T17:40:00Zoai:repositorio.unesp.br:11449/69543Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-09T17:40Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay
title In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay
spellingShingle In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay
Pugliesi, Gustavo de Carvalho
Austroplenckia populnea
Celastraceae
Chromosome aberrations
Micronucleus test
Animalia
Rattus norvegicus
title_short In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay
title_full In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay
title_fullStr In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay
title_full_unstemmed In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay
title_sort In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay
author Pugliesi, Gustavo de Carvalho
author_facet Pugliesi, Gustavo de Carvalho
De Andrade, Sérgio Faloni
Bastos, Jairo Kenupp
Maistro, Edson Luis [UNESP]
author_role author
author2 De Andrade, Sérgio Faloni
Bastos, Jairo Kenupp
Maistro, Edson Luis [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv UNIFENAS
Universidade do Oeste de Santa Catarina
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Pugliesi, Gustavo de Carvalho
De Andrade, Sérgio Faloni
Bastos, Jairo Kenupp
Maistro, Edson Luis [UNESP]
dc.subject.por.fl_str_mv Austroplenckia populnea
Celastraceae
Chromosome aberrations
Micronucleus test
Animalia
Rattus norvegicus
topic Austroplenckia populnea
Celastraceae
Chromosome aberrations
Micronucleus test
Animalia
Rattus norvegicus
description The clastogenic effect of the A. populnea leaves extract was tested in vivo on bone marrow cells of Wistar rats by evaluating the induction of chromosome aberrations and micronuclei induction on polychromatic erythrocytes. The extract was administered by gavage at doses of 300, 600 and 900mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment. Under the conditions used, A. populnea leaves extract did not induce decrease in mitotic index and did not induce a statistically significant increase in the mean number of micronucleated polychromatic erythrocytes or chromosome aberrations in the bone marrow cells of Wistar rats. © 2007 The Japan Mendel Society.
publishDate 2007
dc.date.none.fl_str_mv 2007-03-01
2014-05-27T11:22:25Z
2014-05-27T11:22:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1508/cytologia.72.1
Cytologia, v. 72, n. 1, p. 1-6, 2007.
0011-4545
http://hdl.handle.net/11449/69543
10.1508/cytologia.72.1
2-s2.0-34248643172
2-s2.0-34248643172.pdf
4787521613038315
0000-0003-0757-7876
url http://dx.doi.org/10.1508/cytologia.72.1
http://hdl.handle.net/11449/69543
identifier_str_mv Cytologia, v. 72, n. 1, p. 1-6, 2007.
0011-4545
10.1508/cytologia.72.1
2-s2.0-34248643172
2-s2.0-34248643172.pdf
4787521613038315
0000-0003-0757-7876
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cytologia
0.481
0,233
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-6
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128187762212864

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