Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/s13567-019-0722-3 http://hdl.handle.net/11449/198217 |
Resumo: | Understanding the immunological basis of resistance to gastrointestinal nematode infections in livestock is important in order to develop novel methods of parasite control such as vaccination or genetic selection for parasite resistance. The present study aimed to investigate differences in immune response between parasite resistant Santa Ines and susceptible Ile de France sheep breeds to natural Haemonchus contortus infection. Parasitological parameters, humoral immunity, local and circulating cellular immune responses were evaluated in 19 Santa Ines and 19 Ile de France lambs undergoing different anthelmintic treatments regimens: suppressive treatments (SUP) or targeted selective treatments (TST) over a 5-month grazing period. Santa Ines lambs had significantly lower Haemonchus faecal egg count and worm burden compared to Ile de France regardless of treatment regime. In addition, circulating blood eosinophils count and parasite-specific IgG levels were significantly higher and more rapidly induced in Santa Ines lambs. Abomasal immune responses were generally greater in the resistant breed, which had significantly higher levels of parasite-specific IgA in mucus, and elevated number of globule leukocytes and CD3+ T cells within the abomasal mucosal. Furthermore, numbers of POU2F3+ epithelial cells, a tuft-cell specific transcription factor, were also elevated in the Santa Ines breed, suggesting that this breed is better able to initiate T-helper type 2 immune responses within the abomasum. In conclusion, the differential immunological responses detailed here are relevant to understanding resistance to gastrointestinal nematodes in other host breeds, as well as to resistance breeding as a sustainable control approach for parasitic infections. |
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Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimensUnderstanding the immunological basis of resistance to gastrointestinal nematode infections in livestock is important in order to develop novel methods of parasite control such as vaccination or genetic selection for parasite resistance. The present study aimed to investigate differences in immune response between parasite resistant Santa Ines and susceptible Ile de France sheep breeds to natural Haemonchus contortus infection. Parasitological parameters, humoral immunity, local and circulating cellular immune responses were evaluated in 19 Santa Ines and 19 Ile de France lambs undergoing different anthelmintic treatments regimens: suppressive treatments (SUP) or targeted selective treatments (TST) over a 5-month grazing period. Santa Ines lambs had significantly lower Haemonchus faecal egg count and worm burden compared to Ile de France regardless of treatment regime. In addition, circulating blood eosinophils count and parasite-specific IgG levels were significantly higher and more rapidly induced in Santa Ines lambs. Abomasal immune responses were generally greater in the resistant breed, which had significantly higher levels of parasite-specific IgA in mucus, and elevated number of globule leukocytes and CD3+ T cells within the abomasal mucosal. Furthermore, numbers of POU2F3+ epithelial cells, a tuft-cell specific transcription factor, were also elevated in the Santa Ines breed, suggesting that this breed is better able to initiate T-helper type 2 immune responses within the abomasum. In conclusion, the differential immunological responses detailed here are relevant to understanding resistance to gastrointestinal nematodes in other host breeds, as well as to resistance breeding as a sustainable control approach for parasitic infections.School of Veterinary Medicine and Animal Science UNESP-São Paulo State University, Rua Professor Doutor Walter Mauricio Correa s/nInstitute of Biosciences UNESP-São Paulo State University, Rua Professor Dr. Antônio Celso Wagner Zanin, 250Institute of Biodiversity Animal Health and Comparative Medicine UoG-University of GlasgowDisease Control Division MRI -Moredun Research Institute, Pentlands Science Park, Bush LoanSchool of Veterinary Medicine and Animal Science UNESP-São Paulo State University, Rua Professor Doutor Walter Mauricio Correa s/nInstitute of Biosciences UNESP-São Paulo State University, Rua Professor Dr. Antônio Celso Wagner Zanin, 250Universidade Estadual Paulista (Unesp)UoG-University of GlasgowMRI -Moredun Research InstituteAlbuquerque, Ana Cláudia A. [UNESP]Bassetto, Cesar Cristiano [UNESP]Almeida, Fabiana A. [UNESP]Hildersley, Katie A.McNeilly, Tom N.Britton, ColletteAmarante, Alessandro F. T. [UNESP]2020-12-12T01:06:45Z2020-12-12T01:06:45Z2019-11-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s13567-019-0722-3Veterinary Research, v. 50, n. 1, 2019.1297-97160928-4249http://hdl.handle.net/11449/19821710.1186/s13567-019-0722-32-s2.0-85075784759Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Researchinfo:eu-repo/semantics/openAccess2021-10-23T10:02:16Zoai:repositorio.unesp.br:11449/198217Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:28:01.821880Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens |
title |
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens |
spellingShingle |
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens Albuquerque, Ana Cláudia A. [UNESP] |
title_short |
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens |
title_full |
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens |
title_fullStr |
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens |
title_full_unstemmed |
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens |
title_sort |
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens |
author |
Albuquerque, Ana Cláudia A. [UNESP] |
author_facet |
Albuquerque, Ana Cláudia A. [UNESP] Bassetto, Cesar Cristiano [UNESP] Almeida, Fabiana A. [UNESP] Hildersley, Katie A. McNeilly, Tom N. Britton, Collette Amarante, Alessandro F. T. [UNESP] |
author_role |
author |
author2 |
Bassetto, Cesar Cristiano [UNESP] Almeida, Fabiana A. [UNESP] Hildersley, Katie A. McNeilly, Tom N. Britton, Collette Amarante, Alessandro F. T. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) UoG-University of Glasgow MRI -Moredun Research Institute |
dc.contributor.author.fl_str_mv |
Albuquerque, Ana Cláudia A. [UNESP] Bassetto, Cesar Cristiano [UNESP] Almeida, Fabiana A. [UNESP] Hildersley, Katie A. McNeilly, Tom N. Britton, Collette Amarante, Alessandro F. T. [UNESP] |
description |
Understanding the immunological basis of resistance to gastrointestinal nematode infections in livestock is important in order to develop novel methods of parasite control such as vaccination or genetic selection for parasite resistance. The present study aimed to investigate differences in immune response between parasite resistant Santa Ines and susceptible Ile de France sheep breeds to natural Haemonchus contortus infection. Parasitological parameters, humoral immunity, local and circulating cellular immune responses were evaluated in 19 Santa Ines and 19 Ile de France lambs undergoing different anthelmintic treatments regimens: suppressive treatments (SUP) or targeted selective treatments (TST) over a 5-month grazing period. Santa Ines lambs had significantly lower Haemonchus faecal egg count and worm burden compared to Ile de France regardless of treatment regime. In addition, circulating blood eosinophils count and parasite-specific IgG levels were significantly higher and more rapidly induced in Santa Ines lambs. Abomasal immune responses were generally greater in the resistant breed, which had significantly higher levels of parasite-specific IgA in mucus, and elevated number of globule leukocytes and CD3+ T cells within the abomasal mucosal. Furthermore, numbers of POU2F3+ epithelial cells, a tuft-cell specific transcription factor, were also elevated in the Santa Ines breed, suggesting that this breed is better able to initiate T-helper type 2 immune responses within the abomasum. In conclusion, the differential immunological responses detailed here are relevant to understanding resistance to gastrointestinal nematodes in other host breeds, as well as to resistance breeding as a sustainable control approach for parasitic infections. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-29 2020-12-12T01:06:45Z 2020-12-12T01:06:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s13567-019-0722-3 Veterinary Research, v. 50, n. 1, 2019. 1297-9716 0928-4249 http://hdl.handle.net/11449/198217 10.1186/s13567-019-0722-3 2-s2.0-85075784759 |
url |
http://dx.doi.org/10.1186/s13567-019-0722-3 http://hdl.handle.net/11449/198217 |
identifier_str_mv |
Veterinary Research, v. 50, n. 1, 2019. 1297-9716 0928-4249 10.1186/s13567-019-0722-3 2-s2.0-85075784759 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Veterinary Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128937094545408 |