Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1516-4446-2012-3503 http://hdl.handle.net/11449/74996 |
Resumo: | Objective: To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short- and long-term prognosis thereof. Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012. Based on the search terms mild cognitive impairment or MCI and epidemiology or diagnosis, we retrieved 1,698 articles, of which 248 were critically eligible (cross-sectional and longitudinal studies); the abstracts of the remaining 1,450 articles were also reviewed. Results: A critical review on the MCI construct is provided, including conceptual and diagnostic aspects; epidemiological relevance; clinical assessment; prognosis; and outcome. The distinct definitions of cognitive impairment, MCI included, yield clinically heterogeneous groups of individuals. Those who will eventually progress to dementia may present with symptoms consistent with the definition of MCI; conversely, individuals with MCI may remain stable or return to normal cognitive function. Conclusion: On clinical grounds, the cross-sectional diagnosis of MCI has limited prognostic relevance. The characterization of persistent and/or progressive cognitive deficits over time is a better approach for identification of cases at the pre-dementia stages, particularly if these cognitive abnormalities are consistent with the natural history of incipient Alzheimer's disease. © 2013 Associação Brasileira de Psiquiatria. |
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Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementiaAlzheimer's diseaseBiomarkersDementiaMild cognitive impairmentbiological markerAlzheimer diseasebibliographic databaseclinical assessmentclinical featuredementiahumaninformation processingmemorymild cognitive impairmentMini Mental State Examinationneuropsychiatryoutcome assessmentprognosispsychologic assessmentriskscoring systemObjective: To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short- and long-term prognosis thereof. Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012. Based on the search terms mild cognitive impairment or MCI and epidemiology or diagnosis, we retrieved 1,698 articles, of which 248 were critically eligible (cross-sectional and longitudinal studies); the abstracts of the remaining 1,450 articles were also reviewed. Results: A critical review on the MCI construct is provided, including conceptual and diagnostic aspects; epidemiological relevance; clinical assessment; prognosis; and outcome. The distinct definitions of cognitive impairment, MCI included, yield clinically heterogeneous groups of individuals. Those who will eventually progress to dementia may present with symptoms consistent with the definition of MCI; conversely, individuals with MCI may remain stable or return to normal cognitive function. Conclusion: On clinical grounds, the cross-sectional diagnosis of MCI has limited prognostic relevance. The characterization of persistent and/or progressive cognitive deficits over time is a better approach for identification of cases at the pre-dementia stages, particularly if these cognitive abnormalities are consistent with the natural history of incipient Alzheimer's disease. © 2013 Associação Brasileira de Psiquiatria.Laboratory of Neuroscience (LIM-27) Department and Institute of Psychiatry Universidade de São Paulo (USP), São Paulo, SPDepartment of Internal Medicine School of Medicine Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MGBiosciences Institute Universidade Estadual Paulista (UNESP), Rio Claro, SPNeuroimmunology Group Laboratory of Immunopharmacology Institute of Biological Sciences, UFMG, Belo Horizonte, MGDepartment of Mental Health School of Medicine UFMG, Belo Horizonte, MGBiosciences Institute Universidade Estadual Paulista (UNESP), Rio Claro, SPUniversidade de São Paulo (USP)Universidade Federal de Minas Gerais (UFMG)Universidade Estadual Paulista (Unesp)Forlenza, Orestes V.Diniz, Breno S.Stella, Florindo [UNESP]Teixeira, Antonio L.Gattaz, Wagner F.2014-05-27T11:28:48Z2014-05-27T11:28:48Z2013-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article178-185application/pdfhttp://dx.doi.org/10.1590/1516-4446-2012-3503Revista Brasileira de Psiquiatria, v. 35, n. 2, p. 178-185, 2013.1516-4446http://hdl.handle.net/11449/7499610.1590/1516-4446-2012-3503S1516-4446-2012-3503WOS:0003225432000142-s2.0-848809785052-s2.0-84880978505.pdf7964386240653380Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Psiquiatria2.0930,803info:eu-repo/semantics/openAccess2023-11-06T06:14:07Zoai:repositorio.unesp.br:11449/74996Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:03:19.958860Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia |
title |
Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia |
spellingShingle |
Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia Forlenza, Orestes V. Alzheimer's disease Biomarkers Dementia Mild cognitive impairment biological marker Alzheimer disease bibliographic database clinical assessment clinical feature dementia human information processing memory mild cognitive impairment Mini Mental State Examination neuropsychiatry outcome assessment prognosis psychologic assessment risk scoring system |
title_short |
Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia |
title_full |
Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia |
title_fullStr |
Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia |
title_full_unstemmed |
Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia |
title_sort |
Mild cognitive impairment (part 1): Clinical characteristics and predictors of dementia |
author |
Forlenza, Orestes V. |
author_facet |
Forlenza, Orestes V. Diniz, Breno S. Stella, Florindo [UNESP] Teixeira, Antonio L. Gattaz, Wagner F. |
author_role |
author |
author2 |
Diniz, Breno S. Stella, Florindo [UNESP] Teixeira, Antonio L. Gattaz, Wagner F. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de Minas Gerais (UFMG) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Forlenza, Orestes V. Diniz, Breno S. Stella, Florindo [UNESP] Teixeira, Antonio L. Gattaz, Wagner F. |
dc.subject.por.fl_str_mv |
Alzheimer's disease Biomarkers Dementia Mild cognitive impairment biological marker Alzheimer disease bibliographic database clinical assessment clinical feature dementia human information processing memory mild cognitive impairment Mini Mental State Examination neuropsychiatry outcome assessment prognosis psychologic assessment risk scoring system |
topic |
Alzheimer's disease Biomarkers Dementia Mild cognitive impairment biological marker Alzheimer disease bibliographic database clinical assessment clinical feature dementia human information processing memory mild cognitive impairment Mini Mental State Examination neuropsychiatry outcome assessment prognosis psychologic assessment risk scoring system |
description |
Objective: To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short- and long-term prognosis thereof. Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012. Based on the search terms mild cognitive impairment or MCI and epidemiology or diagnosis, we retrieved 1,698 articles, of which 248 were critically eligible (cross-sectional and longitudinal studies); the abstracts of the remaining 1,450 articles were also reviewed. Results: A critical review on the MCI construct is provided, including conceptual and diagnostic aspects; epidemiological relevance; clinical assessment; prognosis; and outcome. The distinct definitions of cognitive impairment, MCI included, yield clinically heterogeneous groups of individuals. Those who will eventually progress to dementia may present with symptoms consistent with the definition of MCI; conversely, individuals with MCI may remain stable or return to normal cognitive function. Conclusion: On clinical grounds, the cross-sectional diagnosis of MCI has limited prognostic relevance. The characterization of persistent and/or progressive cognitive deficits over time is a better approach for identification of cases at the pre-dementia stages, particularly if these cognitive abnormalities are consistent with the natural history of incipient Alzheimer's disease. © 2013 Associação Brasileira de Psiquiatria. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 2014-05-27T11:28:48Z 2014-05-27T11:28:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1516-4446-2012-3503 Revista Brasileira de Psiquiatria, v. 35, n. 2, p. 178-185, 2013. 1516-4446 http://hdl.handle.net/11449/74996 10.1590/1516-4446-2012-3503 S1516-4446-2012-3503 WOS:000322543200014 2-s2.0-84880978505 2-s2.0-84880978505.pdf 7964386240653380 |
url |
http://dx.doi.org/10.1590/1516-4446-2012-3503 http://hdl.handle.net/11449/74996 |
identifier_str_mv |
Revista Brasileira de Psiquiatria, v. 35, n. 2, p. 178-185, 2013. 1516-4446 10.1590/1516-4446-2012-3503 S1516-4446-2012-3503 WOS:000322543200014 2-s2.0-84880978505 2-s2.0-84880978505.pdf 7964386240653380 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Psiquiatria 2.093 0,803 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
178-185 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128746706698240 |