Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells

Detalhes bibliográficos
Autor(a) principal: Fragoso, Mariana F. [UNESP]
Data de Publicação: 2018
Outros Autores: Romualdo, Guilherme R. [UNESP], Vanderveer, Lisa A., Franco-Barraza, Janusz, Cukierman, Edna, Clapper, Margie L., Carvalho, Robson F. [UNESP], Barbisan, Luis F. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.fct.2018.08.078
http://hdl.handle.net/11449/176819
Resumo: This study evaluated the possible protective effects of lyophilized açaí pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying effect of cyanidin 3-rutinoside (C3R) on the motility of RKO colon adenocarcinoma cells, using the wound healing assay. Male Wistar rats were induced to develop CAC using 1,2-dimethylhydrazine (DMH) and 2,4,6-trinitrobenzene acid (TNBS). Animals were randomly assigned to different groups that received basal diet or basal diet supplemented with 5.0% or 7.5% lyophilized AP. The findings indicate: 1) C3R (25 μM) has the potential to reduce RKO cell motility in vitro; 2) ingestion of lyophilized AP reduces the total number of aberrant crypt foci (ACF), ACF multiplicity, tumor cell proliferation and incidence of tumors with high grade dysplasia; 3) AP increases the gene expression of negative regulators of cell proliferation such as Dlc1 and Akt3, as well as inflammation (Ppara). Thus, lyophilized AP could exert a potential antitumor activity.
id UNSP_9429a0499ccb14b406a33714b924315b
oai_identifier_str oai:repositorio.unesp.br:11449/176819
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cellsColitisColon carcinogenesisCyanidin 3-rutinosideLyophilized açaí pulpPreventionThis study evaluated the possible protective effects of lyophilized açaí pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying effect of cyanidin 3-rutinoside (C3R) on the motility of RKO colon adenocarcinoma cells, using the wound healing assay. Male Wistar rats were induced to develop CAC using 1,2-dimethylhydrazine (DMH) and 2,4,6-trinitrobenzene acid (TNBS). Animals were randomly assigned to different groups that received basal diet or basal diet supplemented with 5.0% or 7.5% lyophilized AP. The findings indicate: 1) C3R (25 μM) has the potential to reduce RKO cell motility in vitro; 2) ingestion of lyophilized AP reduces the total number of aberrant crypt foci (ACF), ACF multiplicity, tumor cell proliferation and incidence of tumors with high grade dysplasia; 3) AP increases the gene expression of negative regulators of cell proliferation such as Dlc1 and Akt3, as well as inflammation (Ppara). Thus, lyophilized AP could exert a potential antitumor activity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Department of Pathology Botucatu Medical School UNESPCancer Prevention and Control Program Fox Chase Cancer CenterCancer Biology Program Fox Chase Cancer CenterDepartment of Morphology Institute of Biosciences of Botucatu UNESPDepartment of Pathology Botucatu Medical School UNESPDepartment of Morphology Institute of Biosciences of Botucatu UNESPFAPESP: 2013/17600-0CAPES: PDSE 008192/2014-06Universidade Estadual Paulista (Unesp)Fox Chase Cancer CenterFragoso, Mariana F. [UNESP]Romualdo, Guilherme R. [UNESP]Vanderveer, Lisa A.Franco-Barraza, JanuszCukierman, EdnaClapper, Margie L.Carvalho, Robson F. [UNESP]Barbisan, Luis F. [UNESP]2018-12-11T17:22:37Z2018-12-11T17:22:37Z2018-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article237-245application/pdfhttp://dx.doi.org/10.1016/j.fct.2018.08.078Food and Chemical Toxicology, v. 121, p. 237-245.1873-63510278-6915http://hdl.handle.net/11449/17681910.1016/j.fct.2018.08.0782-s2.0-850530260752-s2.0-85053026075.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood and Chemical Toxicology1,144info:eu-repo/semantics/openAccess2024-09-03T13:18:43Zoai:repositorio.unesp.br:11449/176819Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
title Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
spellingShingle Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
Fragoso, Mariana F. [UNESP]
Colitis
Colon carcinogenesis
Cyanidin 3-rutinoside
Lyophilized açaí pulp
Prevention
title_short Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
title_full Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
title_fullStr Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
title_full_unstemmed Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
title_sort Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
author Fragoso, Mariana F. [UNESP]
author_facet Fragoso, Mariana F. [UNESP]
Romualdo, Guilherme R. [UNESP]
Vanderveer, Lisa A.
Franco-Barraza, Janusz
Cukierman, Edna
Clapper, Margie L.
Carvalho, Robson F. [UNESP]
Barbisan, Luis F. [UNESP]
author_role author
author2 Romualdo, Guilherme R. [UNESP]
Vanderveer, Lisa A.
Franco-Barraza, Janusz
Cukierman, Edna
Clapper, Margie L.
Carvalho, Robson F. [UNESP]
Barbisan, Luis F. [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Fox Chase Cancer Center
dc.contributor.author.fl_str_mv Fragoso, Mariana F. [UNESP]
Romualdo, Guilherme R. [UNESP]
Vanderveer, Lisa A.
Franco-Barraza, Janusz
Cukierman, Edna
Clapper, Margie L.
Carvalho, Robson F. [UNESP]
Barbisan, Luis F. [UNESP]
dc.subject.por.fl_str_mv Colitis
Colon carcinogenesis
Cyanidin 3-rutinoside
Lyophilized açaí pulp
Prevention
topic Colitis
Colon carcinogenesis
Cyanidin 3-rutinoside
Lyophilized açaí pulp
Prevention
description This study evaluated the possible protective effects of lyophilized açaí pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying effect of cyanidin 3-rutinoside (C3R) on the motility of RKO colon adenocarcinoma cells, using the wound healing assay. Male Wistar rats were induced to develop CAC using 1,2-dimethylhydrazine (DMH) and 2,4,6-trinitrobenzene acid (TNBS). Animals were randomly assigned to different groups that received basal diet or basal diet supplemented with 5.0% or 7.5% lyophilized AP. The findings indicate: 1) C3R (25 μM) has the potential to reduce RKO cell motility in vitro; 2) ingestion of lyophilized AP reduces the total number of aberrant crypt foci (ACF), ACF multiplicity, tumor cell proliferation and incidence of tumors with high grade dysplasia; 3) AP increases the gene expression of negative regulators of cell proliferation such as Dlc1 and Akt3, as well as inflammation (Ppara). Thus, lyophilized AP could exert a potential antitumor activity.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:22:37Z
2018-12-11T17:22:37Z
2018-11-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.fct.2018.08.078
Food and Chemical Toxicology, v. 121, p. 237-245.
1873-6351
0278-6915
http://hdl.handle.net/11449/176819
10.1016/j.fct.2018.08.078
2-s2.0-85053026075
2-s2.0-85053026075.pdf
url http://dx.doi.org/10.1016/j.fct.2018.08.078
http://hdl.handle.net/11449/176819
identifier_str_mv Food and Chemical Toxicology, v. 121, p. 237-245.
1873-6351
0278-6915
10.1016/j.fct.2018.08.078
2-s2.0-85053026075
2-s2.0-85053026075.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Food and Chemical Toxicology
1,144
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 237-245
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1810021424698490880