Genetic variability of inflammatory genes in the brazilian population

• Autor(a) principal: Santos, Marcelo
• Data de Publicação: 2013
• Outros Autores: Sturr, Elaine, Maia, Lucas Lima, Agostini, Lidiane Pignaton, Peterle, Gabriela Tonini, Mendes, Suzanny Oliveira, Silva, Eloiza Helena Tajara da [UNESP], Carvalho, Marcos Brasilino, Louro, Iúri Drumond, Silva-Conforti, Adriana Madeira Álvares da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://online.liebertpub.com/doi/abs/10.1089/gtmb.2013.0264; http://hdl.handle.net/11449/122481

Inflammatory gene variants have been associated with several diseases, including cancer, diabetes, vascular diseases, neurodegenerative diseases, arthritis, and others. Therefore, determining the population genetic composition of inflammation-related genes can be useful for the determination of general risk, prognostic and therapeutic strategies to prevent or cure specific diseases. We have aimed to identify polymorphism genotype frequencies in genes related to the inflammatory response in the Brazilian population, namely, IjBL - 62AT, IjBL - 262CT, tumor necrosis factors alpha (TNFa) - 238GA, TNFa - 308GA, lymphotoxin-alpha (LTa) + 80AC, LTa + 252AG, FAS - 670AG, and FASL - 844TC, considering the white, black, and Pardo ethnicities of the Sa˜o Paulo State. Our results suggest that the Brazilian population is under a miscegenation process at the current time, since some genotypes are not in the Hardy–Weinberg equilibrium. In addition, we conclude that the Pardo ethnicity is derived from a complex mixture of ethnicities, including the native Indian population.