Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992005000200006 http://hdl.handle.net/11449/211853 |
Resumo: | Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral therapy without protease inhibitor (Group 3: G3), mean age 35 years old. The time interval for G2 and G3 was greater than or equal to nine months. Patients receiving HAART with PI had significantly lower viral loads, hypertriglyceridemia, and low HDL levels (p<0.05). There were no differences between groups in relation to the lean body mass percentage obtained by mid-arm muscle circumference adequacy or by bioelectrical impedance. The lower percentage of body fat observed in all the HIV-1 infected patients by antropometric assessment and the decreased tricipital skinfold adequacy in the group treated with PI in relation to CG may suggest lipodystrophy in the upper limbs, especially on those treated with PI. |
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Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapylipodystrophyHIV-1highly active antiretroviral therapydyslipidemiahypertriglyceridemiaHighly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral therapy without protease inhibitor (Group 3: G3), mean age 35 years old. The time interval for G2 and G3 was greater than or equal to nine months. Patients receiving HAART with PI had significantly lower viral loads, hypertriglyceridemia, and low HDL levels (p<0.05). There were no differences between groups in relation to the lean body mass percentage obtained by mid-arm muscle circumference adequacy or by bioelectrical impedance. The lower percentage of body fat observed in all the HIV-1 infected patients by antropometric assessment and the decreased tricipital skinfold adequacy in the group treated with PI in relation to CG may suggest lipodystrophy in the upper limbs, especially on those treated with PI.Universidade Estadual Paulista, Botucatu School of MedicineUniversidade Estadual Paulista, Department of BiostatisticsUniversidade Estadual Paulista, Botucatu School of MedicineUniversidade Estadual Paulista, Department of BiostatisticsCentro de Estudos de Venenos e Animais PeçonhentosUniversidade Estadual Paulista (Unesp)Pontes, L. C. R. [UNESP]Carvalho, L. R. [UNESP]Souza, L. R. [UNESP]Trindade, E. B. S. M. [UNESP]Pereira, P. C. M. [UNESP]2021-07-14T10:30:41Z2021-07-14T10:30:41Z2005-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article143-159application/pdfhttp://dx.doi.org/10.1590/S1678-91992005000200006Journal of Venomous Animals and Toxins including Tropical Diseases. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos, v. 11, n. 2, p. 143-159, 2005.1678-9199http://hdl.handle.net/11449/21185310.1590/S1678-91992005000200006S1678-91992005000200006S1678-91992005000200006.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins including Tropical Diseasesinfo:eu-repo/semantics/openAccess2023-11-16T06:15:03Zoai:repositorio.unesp.br:11449/211853Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:53:10.063893Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
spellingShingle |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy Pontes, L. C. R. [UNESP] lipodystrophy HIV-1 highly active antiretroviral therapy dyslipidemia hypertriglyceridemia |
title_short |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_full |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_fullStr |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_full_unstemmed |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_sort |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
author |
Pontes, L. C. R. [UNESP] |
author_facet |
Pontes, L. C. R. [UNESP] Carvalho, L. R. [UNESP] Souza, L. R. [UNESP] Trindade, E. B. S. M. [UNESP] Pereira, P. C. M. [UNESP] |
author_role |
author |
author2 |
Carvalho, L. R. [UNESP] Souza, L. R. [UNESP] Trindade, E. B. S. M. [UNESP] Pereira, P. C. M. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pontes, L. C. R. [UNESP] Carvalho, L. R. [UNESP] Souza, L. R. [UNESP] Trindade, E. B. S. M. [UNESP] Pereira, P. C. M. [UNESP] |
dc.subject.por.fl_str_mv |
lipodystrophy HIV-1 highly active antiretroviral therapy dyslipidemia hypertriglyceridemia |
topic |
lipodystrophy HIV-1 highly active antiretroviral therapy dyslipidemia hypertriglyceridemia |
description |
Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral therapy without protease inhibitor (Group 3: G3), mean age 35 years old. The time interval for G2 and G3 was greater than or equal to nine months. Patients receiving HAART with PI had significantly lower viral loads, hypertriglyceridemia, and low HDL levels (p<0.05). There were no differences between groups in relation to the lean body mass percentage obtained by mid-arm muscle circumference adequacy or by bioelectrical impedance. The lower percentage of body fat observed in all the HIV-1 infected patients by antropometric assessment and the decreased tricipital skinfold adequacy in the group treated with PI in relation to CG may suggest lipodystrophy in the upper limbs, especially on those treated with PI. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-06 2021-07-14T10:30:41Z 2021-07-14T10:30:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992005000200006 Journal of Venomous Animals and Toxins including Tropical Diseases. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos, v. 11, n. 2, p. 143-159, 2005. 1678-9199 http://hdl.handle.net/11449/211853 10.1590/S1678-91992005000200006 S1678-91992005000200006 S1678-91992005000200006.pdf |
url |
http://dx.doi.org/10.1590/S1678-91992005000200006 http://hdl.handle.net/11449/211853 |
identifier_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos, v. 11, n. 2, p. 143-159, 2005. 1678-9199 10.1590/S1678-91992005000200006 S1678-91992005000200006 S1678-91992005000200006.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
143-159 application/pdf |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128870597001216 |