Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy

Detalhes bibliográficos
Autor(a) principal: Pontes, L. C. R. [UNESP]
Data de Publicação: 2005
Outros Autores: Carvalho, L. R. [UNESP], Souza, L. R. [UNESP], Trindade, E. B. S. M. [UNESP], Pereira, P. C. M. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-91992005000200006
http://hdl.handle.net/11449/211853
Resumo: Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral therapy without protease inhibitor (Group 3: G3), mean age 35 years old. The time interval for G2 and G3 was greater than or equal to nine months. Patients receiving HAART with PI had significantly lower viral loads, hypertriglyceridemia, and low HDL levels (p<0.05). There were no differences between groups in relation to the lean body mass percentage obtained by mid-arm muscle circumference adequacy or by bioelectrical impedance. The lower percentage of body fat observed in all the HIV-1 infected patients by antropometric assessment and the decreased tricipital skinfold adequacy in the group treated with PI in relation to CG may suggest lipodystrophy in the upper limbs, especially on those treated with PI.
id UNSP_951a766c2c4d5dfd1857a42f7db4c7e2
oai_identifier_str oai:repositorio.unesp.br:11449/211853
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapylipodystrophyHIV-1highly active antiretroviral therapydyslipidemiahypertriglyceridemiaHighly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral therapy without protease inhibitor (Group 3: G3), mean age 35 years old. The time interval for G2 and G3 was greater than or equal to nine months. Patients receiving HAART with PI had significantly lower viral loads, hypertriglyceridemia, and low HDL levels (p<0.05). There were no differences between groups in relation to the lean body mass percentage obtained by mid-arm muscle circumference adequacy or by bioelectrical impedance. The lower percentage of body fat observed in all the HIV-1 infected patients by antropometric assessment and the decreased tricipital skinfold adequacy in the group treated with PI in relation to CG may suggest lipodystrophy in the upper limbs, especially on those treated with PI.Universidade Estadual Paulista, Botucatu School of MedicineUniversidade Estadual Paulista, Department of BiostatisticsUniversidade Estadual Paulista, Botucatu School of MedicineUniversidade Estadual Paulista, Department of BiostatisticsCentro de Estudos de Venenos e Animais PeçonhentosUniversidade Estadual Paulista (Unesp)Pontes, L. C. R. [UNESP]Carvalho, L. R. [UNESP]Souza, L. R. [UNESP]Trindade, E. B. S. M. [UNESP]Pereira, P. C. M. [UNESP]2021-07-14T10:30:41Z2021-07-14T10:30:41Z2005-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article143-159application/pdfhttp://dx.doi.org/10.1590/S1678-91992005000200006Journal of Venomous Animals and Toxins including Tropical Diseases. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos, v. 11, n. 2, p. 143-159, 2005.1678-9199http://hdl.handle.net/11449/21185310.1590/S1678-91992005000200006S1678-91992005000200006S1678-91992005000200006.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins including Tropical Diseasesinfo:eu-repo/semantics/openAccess2023-11-16T06:15:03Zoai:repositorio.unesp.br:11449/211853Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:53:10.063893Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
title Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
spellingShingle Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
Pontes, L. C. R. [UNESP]
lipodystrophy
HIV-1
highly active antiretroviral therapy
dyslipidemia
hypertriglyceridemia
title_short Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
title_full Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
title_fullStr Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
title_full_unstemmed Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
title_sort Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
author Pontes, L. C. R. [UNESP]
author_facet Pontes, L. C. R. [UNESP]
Carvalho, L. R. [UNESP]
Souza, L. R. [UNESP]
Trindade, E. B. S. M. [UNESP]
Pereira, P. C. M. [UNESP]
author_role author
author2 Carvalho, L. R. [UNESP]
Souza, L. R. [UNESP]
Trindade, E. B. S. M. [UNESP]
Pereira, P. C. M. [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Pontes, L. C. R. [UNESP]
Carvalho, L. R. [UNESP]
Souza, L. R. [UNESP]
Trindade, E. B. S. M. [UNESP]
Pereira, P. C. M. [UNESP]
dc.subject.por.fl_str_mv lipodystrophy
HIV-1
highly active antiretroviral therapy
dyslipidemia
hypertriglyceridemia
topic lipodystrophy
HIV-1
highly active antiretroviral therapy
dyslipidemia
hypertriglyceridemia
description Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral therapy without protease inhibitor (Group 3: G3), mean age 35 years old. The time interval for G2 and G3 was greater than or equal to nine months. Patients receiving HAART with PI had significantly lower viral loads, hypertriglyceridemia, and low HDL levels (p<0.05). There were no differences between groups in relation to the lean body mass percentage obtained by mid-arm muscle circumference adequacy or by bioelectrical impedance. The lower percentage of body fat observed in all the HIV-1 infected patients by antropometric assessment and the decreased tricipital skinfold adequacy in the group treated with PI in relation to CG may suggest lipodystrophy in the upper limbs, especially on those treated with PI.
publishDate 2005
dc.date.none.fl_str_mv 2005-06
2021-07-14T10:30:41Z
2021-07-14T10:30:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-91992005000200006
Journal of Venomous Animals and Toxins including Tropical Diseases. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos, v. 11, n. 2, p. 143-159, 2005.
1678-9199
http://hdl.handle.net/11449/211853
10.1590/S1678-91992005000200006
S1678-91992005000200006
S1678-91992005000200006.pdf
url http://dx.doi.org/10.1590/S1678-91992005000200006
http://hdl.handle.net/11449/211853
identifier_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos, v. 11, n. 2, p. 143-159, 2005.
1678-9199
10.1590/S1678-91992005000200006
S1678-91992005000200006
S1678-91992005000200006.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 143-159
application/pdf
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128870597001216