Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://ajpregu.physiology.org/content/275/5/R1431 http://hdl.handle.net/11449/36144 |
Resumo: | The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 mu g . 200 nl(-1). site(-1)) increased the intake of 0.3 ill NaCl induced by intracerebroventricular ANG II (50 ng/1 mu l). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 mu g . 200 nl(-1). site(-1)) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states. |
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Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetitesodium chloride intakewater intakeproglumidesodium appetiteThe present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 mu g . 200 nl(-1). site(-1)) increased the intake of 0.3 ill NaCl induced by intracerebroventricular ANG II (50 ng/1 mu l). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 mu g . 200 nl(-1). site(-1)) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.Univ Iowa, Dept Psychol, Iowa City, IA 52242 USAUniv Iowa, Dept Pharmacol, Iowa City, IA 52242 USAUniv Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USAPaulista State Univ, Fac Odontol, Dept Ciências Fisiol, BR-14801903 São Paulo, BrazilPaulista State Univ, Fac Odontol, Dept Ciências Fisiol, BR-14801903 São Paulo, BrazilAmer Physiological SocUniv IowaUniversidade Estadual Paulista (Unesp)Menani, José Vanderlei [UNESP]Johnson, A. K.2014-05-20T15:25:48Z2014-05-20T15:25:48Z1998-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleR1431-R1437http://ajpregu.physiology.org/content/275/5/R1431American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 275, n. 5, p. R1431-R1437, 1998.0363-6119http://hdl.handle.net/11449/36144WOS:0000768807000071023597870118105Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology3.0821,550info:eu-repo/semantics/openAccess2021-10-23T11:03:31Zoai:repositorio.unesp.br:11449/36144Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T11:03:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite |
title |
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite |
spellingShingle |
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite Menani, José Vanderlei [UNESP] sodium chloride intake water intake proglumide sodium appetite |
title_short |
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite |
title_full |
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite |
title_fullStr |
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite |
title_full_unstemmed |
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite |
title_sort |
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite |
author |
Menani, José Vanderlei [UNESP] |
author_facet |
Menani, José Vanderlei [UNESP] Johnson, A. K. |
author_role |
author |
author2 |
Johnson, A. K. |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Univ Iowa Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Menani, José Vanderlei [UNESP] Johnson, A. K. |
dc.subject.por.fl_str_mv |
sodium chloride intake water intake proglumide sodium appetite |
topic |
sodium chloride intake water intake proglumide sodium appetite |
description |
The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 mu g . 200 nl(-1). site(-1)) increased the intake of 0.3 ill NaCl induced by intracerebroventricular ANG II (50 ng/1 mu l). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 mu g . 200 nl(-1). site(-1)) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-11-01 2014-05-20T15:25:48Z 2014-05-20T15:25:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://ajpregu.physiology.org/content/275/5/R1431 American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 275, n. 5, p. R1431-R1437, 1998. 0363-6119 http://hdl.handle.net/11449/36144 WOS:000076880700007 1023597870118105 |
url |
http://ajpregu.physiology.org/content/275/5/R1431 http://hdl.handle.net/11449/36144 |
identifier_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 275, n. 5, p. R1431-R1437, 1998. 0363-6119 WOS:000076880700007 1023597870118105 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Physiology: Regulatory Integrative and Comparative Physiology 3.082 1,550 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
R1431-R1437 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965128500707328 |