Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite

Detalhes bibliográficos
Autor(a) principal: Menani, José Vanderlei [UNESP]
Data de Publicação: 1998
Outros Autores: Johnson, A. K.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://ajpregu.physiology.org/content/275/5/R1431
http://hdl.handle.net/11449/36144
Resumo: The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 mu g . 200 nl(-1). site(-1)) increased the intake of 0.3 ill NaCl induced by intracerebroventricular ANG II (50 ng/1 mu l). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 mu g . 200 nl(-1). site(-1)) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.
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spelling Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetitesodium chloride intakewater intakeproglumidesodium appetiteThe present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 mu g . 200 nl(-1). site(-1)) increased the intake of 0.3 ill NaCl induced by intracerebroventricular ANG II (50 ng/1 mu l). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 mu g . 200 nl(-1). site(-1)) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.Univ Iowa, Dept Psychol, Iowa City, IA 52242 USAUniv Iowa, Dept Pharmacol, Iowa City, IA 52242 USAUniv Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USAPaulista State Univ, Fac Odontol, Dept Ciências Fisiol, BR-14801903 São Paulo, BrazilPaulista State Univ, Fac Odontol, Dept Ciências Fisiol, BR-14801903 São Paulo, BrazilAmer Physiological SocUniv IowaUniversidade Estadual Paulista (Unesp)Menani, José Vanderlei [UNESP]Johnson, A. K.2014-05-20T15:25:48Z2014-05-20T15:25:48Z1998-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleR1431-R1437http://ajpregu.physiology.org/content/275/5/R1431American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 275, n. 5, p. R1431-R1437, 1998.0363-6119http://hdl.handle.net/11449/36144WOS:0000768807000071023597870118105Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology3.0821,550info:eu-repo/semantics/openAccess2021-10-23T11:03:31Zoai:repositorio.unesp.br:11449/36144Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T11:03:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
title Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
spellingShingle Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
Menani, José Vanderlei [UNESP]
sodium chloride intake
water intake
proglumide
sodium appetite
title_short Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
title_full Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
title_fullStr Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
title_full_unstemmed Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
title_sort Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
author Menani, José Vanderlei [UNESP]
author_facet Menani, José Vanderlei [UNESP]
Johnson, A. K.
author_role author
author2 Johnson, A. K.
author2_role author
dc.contributor.none.fl_str_mv Univ Iowa
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Menani, José Vanderlei [UNESP]
Johnson, A. K.
dc.subject.por.fl_str_mv sodium chloride intake
water intake
proglumide
sodium appetite
topic sodium chloride intake
water intake
proglumide
sodium appetite
description The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 mu g . 200 nl(-1). site(-1)) increased the intake of 0.3 ill NaCl induced by intracerebroventricular ANG II (50 ng/1 mu l). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 mu g . 200 nl(-1). site(-1)) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.
publishDate 1998
dc.date.none.fl_str_mv 1998-11-01
2014-05-20T15:25:48Z
2014-05-20T15:25:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://ajpregu.physiology.org/content/275/5/R1431
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 275, n. 5, p. R1431-R1437, 1998.
0363-6119
http://hdl.handle.net/11449/36144
WOS:000076880700007
1023597870118105
url http://ajpregu.physiology.org/content/275/5/R1431
http://hdl.handle.net/11449/36144
identifier_str_mv American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 275, n. 5, p. R1431-R1437, 1998.
0363-6119
WOS:000076880700007
1023597870118105
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv American Journal of Physiology: Regulatory Integrative and Comparative Physiology
3.082
1,550
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv R1431-R1437
dc.publisher.none.fl_str_mv Amer Physiological Soc
publisher.none.fl_str_mv Amer Physiological Soc
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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