Acmella oleracea and Achyrocline satureioides as Sources of Natural Products in Topical Wound Care

• Autor(a) principal: Yamane, Lais Thiemi
• Data de Publicação: 2016
• Outros Autores: Paula, Eneida de, Jorge, Michelle Pedroza, Freitas-Blanco, Veronica Santana de, Montanari Junior, Ilio, Figueira, Glyn Mara, Anholeto, Luis Adriano [UNESP], Oliveira, Patricia Rosa de [UNESP], Ferreira Rodrigues, Rodney Alexandre
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1155/2016/3606820; http://hdl.handle.net/11449/162035

The Brazilian forests have one of the world's biggest biodiversities. Achyrocline satureioides (macela) and Acmella oleracea (jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu's crude extract after depigmentation with activated charcoal and macela's essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities by in vivo tests: wound healing and antinociceptive. The film containing the highest concentration of depigmented jambu's extract and macela's essential oil obtained an anesthesia time of 83.6 (+/- 28.5) min longer when compared with the positive control EMLA (R); the same occurred with the wound healing test; the film containing the highest concentration had a higherwound contraction (62.0%+/- 12.1) compared to the positive control allantoin and the histopathological analysis demonstrated that it increases collagen synthesis and epidermal thickening. The results demonstrate that the films have a potential use in skin wounds, pressure sore, and infected surgical wounds treatment.