Preparation and characterization of boron-based bioglass by sol−gel process

Detalhes bibliográficos
Autor(a) principal: Furlan, Roberto Gustavo
Data de Publicação: 2018
Outros Autores: Correr, Wagner Raphael, Russi, Ana Flavia Costa, da Costa Iemma, Mônica Rosas, Trovatti, Eliane, Pecoraro, Édison [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10971-018-4806-8
http://hdl.handle.net/11449/180196
Resumo: 45S5 bioglass has been widely studied in the last few decades because of its bioactivity and promising applications in the biomedical field. Boron, even few studied, represents a potential element to improve the properties of the 45S5 bioglass derivatives. The bioglasses are conventionally prepared by heat treatment of oxides and silicon. Here, the sol−gel method is proposed for the preparation of the boron-based 45S5 bioglass (45S5B) and the classical 45S5 bioglass (45S5), using water-soluble salts as raw materials. The bioglasses were characterized by FTIR, XRD, and SEM, indicating the success of the sol−gel method for preparation of the samples. The bioglasses were also tested in vitro for bioactivity in biological conditions and cytotoxicity against eukaryotic cells. The bioactivity of 45S5B was similar to the bioactivity of 45S5 bioglass, indicated by the deposition of hydroxyapatite crystals at the surface of the pristine bioglasses. The results of cytotoxicity tests revealed that the IC50 of 45S5B (IC50 = 7.56 mg mL−1) was similar to the IC50 of 45S5 (IC50 = 8.15 mg mL−1), indicating its safety for application in the biomedical field. [Figure not available: see fulltext.].
id UNSP_966835b03065b38dd2aef8ddc337a2be
oai_identifier_str oai:repositorio.unesp.br:11449/180196
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Preparation and characterization of boron-based bioglass by sol−gel process45S5BioglassBoronCytotoxicityin vitroOSTEO-1 cells45S5 bioglass has been widely studied in the last few decades because of its bioactivity and promising applications in the biomedical field. Boron, even few studied, represents a potential element to improve the properties of the 45S5 bioglass derivatives. The bioglasses are conventionally prepared by heat treatment of oxides and silicon. Here, the sol−gel method is proposed for the preparation of the boron-based 45S5 bioglass (45S5B) and the classical 45S5 bioglass (45S5), using water-soluble salts as raw materials. The bioglasses were characterized by FTIR, XRD, and SEM, indicating the success of the sol−gel method for preparation of the samples. The bioglasses were also tested in vitro for bioactivity in biological conditions and cytotoxicity against eukaryotic cells. The bioactivity of 45S5B was similar to the bioactivity of 45S5 bioglass, indicated by the deposition of hydroxyapatite crystals at the surface of the pristine bioglasses. The results of cytotoxicity tests revealed that the IC50 of 45S5B (IC50 = 7.56 mg mL−1) was similar to the IC50 of 45S5 (IC50 = 8.15 mg mL−1), indicating its safety for application in the biomedical field. [Figure not available: see fulltext.].University of Araraquara—UNIARA, Rua Carlos Gomes, 1217Centre d’Optique Photonique et Laser Université Laval, 2375 rue de la TerrasseInstituto de Física de São Carlos Universidade de São PauloInstitute of Chemistry UNESP—São Paulo State UniversityInstitute of Chemistry UNESP—São Paulo State UniversityUniversity of Araraquara—UNIARAUniversité LavalUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Furlan, Roberto GustavoCorrer, Wagner RaphaelRussi, Ana Flavia Costada Costa Iemma, Mônica RosasTrovatti, ElianePecoraro, Édison [UNESP]2018-12-11T17:38:35Z2018-12-11T17:38:35Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1007/s10971-018-4806-8Journal of Sol-Gel Science and Technology.1573-48460928-0707http://hdl.handle.net/11449/18019610.1007/s10971-018-4806-82-s2.0-850536119992-s2.0-85053611999.pdf5282584912774370000-0002-5049-8797Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Sol-Gel Science and Technology0,4770,477info:eu-repo/semantics/openAccess2023-12-02T06:10:59Zoai:repositorio.unesp.br:11449/180196Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-02T06:10:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Preparation and characterization of boron-based bioglass by sol−gel process
title Preparation and characterization of boron-based bioglass by sol−gel process
spellingShingle Preparation and characterization of boron-based bioglass by sol−gel process
Furlan, Roberto Gustavo
45S5
Bioglass
Boron
Cytotoxicity
in vitro
OSTEO-1 cells
title_short Preparation and characterization of boron-based bioglass by sol−gel process
title_full Preparation and characterization of boron-based bioglass by sol−gel process
title_fullStr Preparation and characterization of boron-based bioglass by sol−gel process
title_full_unstemmed Preparation and characterization of boron-based bioglass by sol−gel process
title_sort Preparation and characterization of boron-based bioglass by sol−gel process
author Furlan, Roberto Gustavo
author_facet Furlan, Roberto Gustavo
Correr, Wagner Raphael
Russi, Ana Flavia Costa
da Costa Iemma, Mônica Rosas
Trovatti, Eliane
Pecoraro, Édison [UNESP]
author_role author
author2 Correr, Wagner Raphael
Russi, Ana Flavia Costa
da Costa Iemma, Mônica Rosas
Trovatti, Eliane
Pecoraro, Édison [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv University of Araraquara—UNIARA
Université Laval
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Furlan, Roberto Gustavo
Correr, Wagner Raphael
Russi, Ana Flavia Costa
da Costa Iemma, Mônica Rosas
Trovatti, Eliane
Pecoraro, Édison [UNESP]
dc.subject.por.fl_str_mv 45S5
Bioglass
Boron
Cytotoxicity
in vitro
OSTEO-1 cells
topic 45S5
Bioglass
Boron
Cytotoxicity
in vitro
OSTEO-1 cells
description 45S5 bioglass has been widely studied in the last few decades because of its bioactivity and promising applications in the biomedical field. Boron, even few studied, represents a potential element to improve the properties of the 45S5 bioglass derivatives. The bioglasses are conventionally prepared by heat treatment of oxides and silicon. Here, the sol−gel method is proposed for the preparation of the boron-based 45S5 bioglass (45S5B) and the classical 45S5 bioglass (45S5), using water-soluble salts as raw materials. The bioglasses were characterized by FTIR, XRD, and SEM, indicating the success of the sol−gel method for preparation of the samples. The bioglasses were also tested in vitro for bioactivity in biological conditions and cytotoxicity against eukaryotic cells. The bioactivity of 45S5B was similar to the bioactivity of 45S5 bioglass, indicated by the deposition of hydroxyapatite crystals at the surface of the pristine bioglasses. The results of cytotoxicity tests revealed that the IC50 of 45S5B (IC50 = 7.56 mg mL−1) was similar to the IC50 of 45S5 (IC50 = 8.15 mg mL−1), indicating its safety for application in the biomedical field. [Figure not available: see fulltext.].
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:38:35Z
2018-12-11T17:38:35Z
2018-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10971-018-4806-8
Journal of Sol-Gel Science and Technology.
1573-4846
0928-0707
http://hdl.handle.net/11449/180196
10.1007/s10971-018-4806-8
2-s2.0-85053611999
2-s2.0-85053611999.pdf
528258491277437
0000-0002-5049-8797
url http://dx.doi.org/10.1007/s10971-018-4806-8
http://hdl.handle.net/11449/180196
identifier_str_mv Journal of Sol-Gel Science and Technology.
1573-4846
0928-0707
10.1007/s10971-018-4806-8
2-s2.0-85053611999
2-s2.0-85053611999.pdf
528258491277437
0000-0002-5049-8797
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Sol-Gel Science and Technology
0,477
0,477
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965140380024832