Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha

Detalhes bibliográficos
Autor(a) principal: Tasca, Karen Ingrid [UNESP]
Data de Publicação: 2021
Outros Autores: Fagundes Vidal, Vânia V. M., Manfio, Vanessa Martinez [UNESP], Barbosa, Alexandre Naime [UNESP], de Souza, Lenice Do Rosário [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.32725/jab.2021.002
http://hdl.handle.net/11449/207503
Resumo: Background: Despite the many benefits that follow antiretroviral therapy (ART) initiation, its chronic use contributes to the early aging of people living with HIV/AIDS (PLWHA). The aim of this cross-sectional study was to trace the prevalence of and investigate possible renal, bone and metabolic changes, as well as cardiovascular risk in 94 asymptomatic PLWHA, relating them to the duration of ART use. Methods: Four groups were evaluated according to ART use: G1 (n = 21), ART-naïve individuals; G2 (n = 17), <2 years; G3 (n = 40), 2–10 years; and G4 (n = 16) on ART for more than 10 years. Results: Our results showed a high prevalence of dyslipidemic individuals (64%), especially in those under ART. Lower creatine phosphokinase levels were observed in G1 as compared to the others (p < 0.05). Regarding the Framingham score, 12.1% of PLWHA showed moderate and high risk, and the highest proportion (38.5%) occurred in G4 (p = 0.003). A decrease in glomerular filtration rates occurred in 20% of patients, which was also more significant in G3 and G4 (p = 0.007). High prevalences of osteopenia and osteoporosis (53.2%) were found, especially in G1 and G4; however, G1 showed the lowest means for alkaline phosphatases (AP, p = 0.04 and BAP, p = 0.005) and osteocalcin (p = 0.005), in addition to higher vitamin-D concentrations (p = 0.04). Conclusions: Our study showed the possible contributory role of ART in these changes, which leads us to reflect on the need for specific conducts and patient care, pointing out the importance of individualized care in an attempt to increase life expectancy.
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spelling Contributory role of art in the development of non-aids comorbidities in asymptomatic plwhaAntiretroviralDyslipidemiaHIV/AidsNon-AIDS comorbiditiesBackground: Despite the many benefits that follow antiretroviral therapy (ART) initiation, its chronic use contributes to the early aging of people living with HIV/AIDS (PLWHA). The aim of this cross-sectional study was to trace the prevalence of and investigate possible renal, bone and metabolic changes, as well as cardiovascular risk in 94 asymptomatic PLWHA, relating them to the duration of ART use. Methods: Four groups were evaluated according to ART use: G1 (n = 21), ART-naïve individuals; G2 (n = 17), <2 years; G3 (n = 40), 2–10 years; and G4 (n = 16) on ART for more than 10 years. Results: Our results showed a high prevalence of dyslipidemic individuals (64%), especially in those under ART. Lower creatine phosphokinase levels were observed in G1 as compared to the others (p < 0.05). Regarding the Framingham score, 12.1% of PLWHA showed moderate and high risk, and the highest proportion (38.5%) occurred in G4 (p = 0.003). A decrease in glomerular filtration rates occurred in 20% of patients, which was also more significant in G3 and G4 (p = 0.007). High prevalences of osteopenia and osteoporosis (53.2%) were found, especially in G1 and G4; however, G1 showed the lowest means for alkaline phosphatases (AP, p = 0.04 and BAP, p = 0.005) and osteocalcin (p = 0.005), in addition to higher vitamin-D concentrations (p = 0.04). Conclusions: Our study showed the possible contributory role of ART in these changes, which leads us to reflect on the need for specific conducts and patient care, pointing out the importance of individualized care in an attempt to increase life expectancy.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University – UNESP Institute of Biosciences of Botucatu Department of Microbiology and ImmunologySpecialist Outpatient Service for Infectious Diseases “Domingos Alves Meira” (SAEI-DAM)São Paulo State University – UNESP Botucatu Medical School Department of Tropical Diseases and Imaging DiagnosisSão Paulo State University – UNESP Institute of Biosciences of Botucatu Department of Microbiology and ImmunologySão Paulo State University – UNESP Botucatu Medical School Department of Tropical Diseases and Imaging DiagnosisFAPESP: 2016/15440-4Universidade Estadual Paulista (Unesp)Specialist Outpatient Service for Infectious Diseases “Domingos Alves Meira” (SAEI-DAM)Tasca, Karen Ingrid [UNESP]Fagundes Vidal, Vânia V. M.Manfio, Vanessa Martinez [UNESP]Barbosa, Alexandre Naime [UNESP]de Souza, Lenice Do Rosário [UNESP]2021-06-25T10:56:16Z2021-06-25T10:56:16Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article73-82http://dx.doi.org/10.32725/jab.2021.002Journal of Applied Biomedicine, v. 19, n. 1, p. 73-82, 2021.1214-02871214-021Xhttp://hdl.handle.net/11449/20750310.32725/jab.2021.0022-s2.0-85103041859Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Biomedicineinfo:eu-repo/semantics/openAccess2024-08-15T15:23:00Zoai:repositorio.unesp.br:11449/207503Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha
title Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha
spellingShingle Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha
Tasca, Karen Ingrid [UNESP]
Antiretroviral
Dyslipidemia
HIV/Aids
Non-AIDS comorbidities
title_short Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha
title_full Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha
title_fullStr Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha
title_full_unstemmed Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha
title_sort Contributory role of art in the development of non-aids comorbidities in asymptomatic plwha
author Tasca, Karen Ingrid [UNESP]
author_facet Tasca, Karen Ingrid [UNESP]
Fagundes Vidal, Vânia V. M.
Manfio, Vanessa Martinez [UNESP]
Barbosa, Alexandre Naime [UNESP]
de Souza, Lenice Do Rosário [UNESP]
author_role author
author2 Fagundes Vidal, Vânia V. M.
Manfio, Vanessa Martinez [UNESP]
Barbosa, Alexandre Naime [UNESP]
de Souza, Lenice Do Rosário [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Specialist Outpatient Service for Infectious Diseases “Domingos Alves Meira” (SAEI-DAM)
dc.contributor.author.fl_str_mv Tasca, Karen Ingrid [UNESP]
Fagundes Vidal, Vânia V. M.
Manfio, Vanessa Martinez [UNESP]
Barbosa, Alexandre Naime [UNESP]
de Souza, Lenice Do Rosário [UNESP]
dc.subject.por.fl_str_mv Antiretroviral
Dyslipidemia
HIV/Aids
Non-AIDS comorbidities
topic Antiretroviral
Dyslipidemia
HIV/Aids
Non-AIDS comorbidities
description Background: Despite the many benefits that follow antiretroviral therapy (ART) initiation, its chronic use contributes to the early aging of people living with HIV/AIDS (PLWHA). The aim of this cross-sectional study was to trace the prevalence of and investigate possible renal, bone and metabolic changes, as well as cardiovascular risk in 94 asymptomatic PLWHA, relating them to the duration of ART use. Methods: Four groups were evaluated according to ART use: G1 (n = 21), ART-naïve individuals; G2 (n = 17), <2 years; G3 (n = 40), 2–10 years; and G4 (n = 16) on ART for more than 10 years. Results: Our results showed a high prevalence of dyslipidemic individuals (64%), especially in those under ART. Lower creatine phosphokinase levels were observed in G1 as compared to the others (p < 0.05). Regarding the Framingham score, 12.1% of PLWHA showed moderate and high risk, and the highest proportion (38.5%) occurred in G4 (p = 0.003). A decrease in glomerular filtration rates occurred in 20% of patients, which was also more significant in G3 and G4 (p = 0.007). High prevalences of osteopenia and osteoporosis (53.2%) were found, especially in G1 and G4; however, G1 showed the lowest means for alkaline phosphatases (AP, p = 0.04 and BAP, p = 0.005) and osteocalcin (p = 0.005), in addition to higher vitamin-D concentrations (p = 0.04). Conclusions: Our study showed the possible contributory role of ART in these changes, which leads us to reflect on the need for specific conducts and patient care, pointing out the importance of individualized care in an attempt to increase life expectancy.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:56:16Z
2021-06-25T10:56:16Z
2021-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.32725/jab.2021.002
Journal of Applied Biomedicine, v. 19, n. 1, p. 73-82, 2021.
1214-0287
1214-021X
http://hdl.handle.net/11449/207503
10.32725/jab.2021.002
2-s2.0-85103041859
url http://dx.doi.org/10.32725/jab.2021.002
http://hdl.handle.net/11449/207503
identifier_str_mv Journal of Applied Biomedicine, v. 19, n. 1, p. 73-82, 2021.
1214-0287
1214-021X
10.32725/jab.2021.002
2-s2.0-85103041859
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Applied Biomedicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 73-82
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128158248992768