Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.013 http://hdl.handle.net/11449/176471 |
Resumo: | The objective of our study was to evaluate the influence of the superoxide dismutase 1 (SOD1) polymorphisms on erythrocyte SOD1 activity and the mortality of patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon ICU admission. However, 38 patients were excluded. Thus, 137 patients were enrolled in the study. Blood samples were taken within the first 24 h of the patient's admission to determine erythrocyte SOD1 activity and nine SOD1 gene polymorphisms. The mean patient age was 63 ± 16 years, 58% were men, and ICU mortality rate was 66%. The patients who died were older and more severely ill, with higher Acute Physiology and Chronic Health Evaluation (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores, as well as higher lactate, urea, and protein carbonyl levels. In the logistic regression model, erythrocyte SOD1 activity was associated with ICU mortality. This relationship was also maintained in the highest tertile of SOD1 activity (odds ratio [OR]: 0.02; 95% confidence interval [CI]: 0.00–0.78; p = 0.037). Only SNP rs2070424 of the SOD1 gene influenced erythrocyte SOD1 activity. For patients with the AA allele, the activity of SOD1 was lower in relation to G-carriers (A/G+G/G genotype) (p = 0.019). None of the nine SOD1 SNPs were associated with ICU mortality. In conclusion, the SNP rs2070424 of the SOD1 gene interferes with erythrocyte SOD1 activity, and higher activity of SOD1 was associated with decreased mortality in patients with septic shock. |
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Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shockOxidative stressSeptic shockSOD1 activitySOD1 polymorphismsThe objective of our study was to evaluate the influence of the superoxide dismutase 1 (SOD1) polymorphisms on erythrocyte SOD1 activity and the mortality of patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon ICU admission. However, 38 patients were excluded. Thus, 137 patients were enrolled in the study. Blood samples were taken within the first 24 h of the patient's admission to determine erythrocyte SOD1 activity and nine SOD1 gene polymorphisms. The mean patient age was 63 ± 16 years, 58% were men, and ICU mortality rate was 66%. The patients who died were older and more severely ill, with higher Acute Physiology and Chronic Health Evaluation (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores, as well as higher lactate, urea, and protein carbonyl levels. In the logistic regression model, erythrocyte SOD1 activity was associated with ICU mortality. This relationship was also maintained in the highest tertile of SOD1 activity (odds ratio [OR]: 0.02; 95% confidence interval [CI]: 0.00–0.78; p = 0.037). Only SNP rs2070424 of the SOD1 gene influenced erythrocyte SOD1 activity. For patients with the AA allele, the activity of SOD1 was lower in relation to G-carriers (A/G+G/G genotype) (p = 0.019). None of the nine SOD1 SNPs were associated with ICU mortality. In conclusion, the SNP rs2070424 of the SOD1 gene interferes with erythrocyte SOD1 activity, and higher activity of SOD1 was associated with decreased mortality in patients with septic shock.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Internal Medicine Botucatu Medical School UNESP – Univ Estadual PaulistaDepartment of Food and Experimental Nutrition Faculty of Pharmaceutical Science USP - University of São PauloChemistry and Biochemistry Department Institute of Biosciences Univ Estadual Paulista (UNESP)Department of Nutrition School of Public Health USP – University of São PauloDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual PaulistaChemistry and Biochemistry Department Institute of Biosciences Univ Estadual Paulista (UNESP)FAPESP: 2014/07988-4FAPESP: FAPESP−2014/17262-0Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Costa, Nara Aline [UNESP]Cunha, Natália Baraldi [UNESP]Gut, Ana Lucia [UNESP]Azevedo, Paula Schmidt [UNESP]Polegato, Bertha Furlan [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]de Paiva, Sergio Alberto Rupp [UNESP]Reis, Bruna ZavarizeFernandes, Ana Angelica Henrique [UNESP]Rogero, Marcelo MacedoNorde, Marina MaintinguerMinicucci, Marcos Ferreira [UNESP]2018-12-11T17:20:55Z2018-12-11T17:20:55Z2018-08-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article199-204application/pdfhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.06.013Free Radical Biology and Medicine, v. 124, p. 199-204.1873-45960891-5849http://hdl.handle.net/11449/17647110.1016/j.freeradbiomed.2018.06.0132-s2.0-850487147642-s2.0-85048714764.pdf5016839015394547121314080140264774387040344716730000-0002-5843-6232Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFree Radical Biology and Medicine2,178info:eu-repo/semantics/openAccess2023-10-21T06:07:33Zoai:repositorio.unesp.br:11449/176471Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-21T06:07:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock |
title |
Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock |
spellingShingle |
Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock Costa, Nara Aline [UNESP] Oxidative stress Septic shock SOD1 activity SOD1 polymorphisms |
title_short |
Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock |
title_full |
Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock |
title_fullStr |
Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock |
title_full_unstemmed |
Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock |
title_sort |
Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock |
author |
Costa, Nara Aline [UNESP] |
author_facet |
Costa, Nara Aline [UNESP] Cunha, Natália Baraldi [UNESP] Gut, Ana Lucia [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Reis, Bruna Zavarize Fernandes, Ana Angelica Henrique [UNESP] Rogero, Marcelo Macedo Norde, Marina Maintinguer Minicucci, Marcos Ferreira [UNESP] |
author_role |
author |
author2 |
Cunha, Natália Baraldi [UNESP] Gut, Ana Lucia [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Reis, Bruna Zavarize Fernandes, Ana Angelica Henrique [UNESP] Rogero, Marcelo Macedo Norde, Marina Maintinguer Minicucci, Marcos Ferreira [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Costa, Nara Aline [UNESP] Cunha, Natália Baraldi [UNESP] Gut, Ana Lucia [UNESP] Azevedo, Paula Schmidt [UNESP] Polegato, Bertha Furlan [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Reis, Bruna Zavarize Fernandes, Ana Angelica Henrique [UNESP] Rogero, Marcelo Macedo Norde, Marina Maintinguer Minicucci, Marcos Ferreira [UNESP] |
dc.subject.por.fl_str_mv |
Oxidative stress Septic shock SOD1 activity SOD1 polymorphisms |
topic |
Oxidative stress Septic shock SOD1 activity SOD1 polymorphisms |
description |
The objective of our study was to evaluate the influence of the superoxide dismutase 1 (SOD1) polymorphisms on erythrocyte SOD1 activity and the mortality of patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon ICU admission. However, 38 patients were excluded. Thus, 137 patients were enrolled in the study. Blood samples were taken within the first 24 h of the patient's admission to determine erythrocyte SOD1 activity and nine SOD1 gene polymorphisms. The mean patient age was 63 ± 16 years, 58% were men, and ICU mortality rate was 66%. The patients who died were older and more severely ill, with higher Acute Physiology and Chronic Health Evaluation (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores, as well as higher lactate, urea, and protein carbonyl levels. In the logistic regression model, erythrocyte SOD1 activity was associated with ICU mortality. This relationship was also maintained in the highest tertile of SOD1 activity (odds ratio [OR]: 0.02; 95% confidence interval [CI]: 0.00–0.78; p = 0.037). Only SNP rs2070424 of the SOD1 gene influenced erythrocyte SOD1 activity. For patients with the AA allele, the activity of SOD1 was lower in relation to G-carriers (A/G+G/G genotype) (p = 0.019). None of the nine SOD1 SNPs were associated with ICU mortality. In conclusion, the SNP rs2070424 of the SOD1 gene interferes with erythrocyte SOD1 activity, and higher activity of SOD1 was associated with decreased mortality in patients with septic shock. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:20:55Z 2018-12-11T17:20:55Z 2018-08-20 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.013 Free Radical Biology and Medicine, v. 124, p. 199-204. 1873-4596 0891-5849 http://hdl.handle.net/11449/176471 10.1016/j.freeradbiomed.2018.06.013 2-s2.0-85048714764 2-s2.0-85048714764.pdf 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
url |
http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.013 http://hdl.handle.net/11449/176471 |
identifier_str_mv |
Free Radical Biology and Medicine, v. 124, p. 199-204. 1873-4596 0891-5849 10.1016/j.freeradbiomed.2018.06.013 2-s2.0-85048714764 2-s2.0-85048714764.pdf 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Free Radical Biology and Medicine 2,178 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
199-204 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964644291379200 |