Noradrenaline and dobutamine effects on the volume expansion with normal saline in rabbits subjected to hemorrhage

• Autor(a) principal: Ramalho, Gualter Lisboa [UNESP]
• Data de Publicação: 2016
• Outros Autores: Vane, Matheus Fachini, Lima, Luciana Cavalcanti, Vane, Lucas Fachini [UNESP], Amorim, Rosa Beatriz [UNESP], Domingues, Maria Aparecida [UNESP], de Moraes, José Mariano Soares, de Carvalho, Lídia Raquel [UNESP], Tanaka, Pedro Paulo, Vane, Luiz Antonio [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1590/S0102-865020160090000008
• Texto Completo: http://dx.doi.org/10.1590/S0102-865020160090000008; http://hdl.handle.net/11449/173655
• topic: Catecholamines; Hemorrhage; Plasma volume; Rabbits

PURPOSE: To evaluate the effects of dobutamine (DB), noradrenaline (NA), and their combination (NADB), on volume retention in rabbits submitted to hemorrhage. METHODS: Thirty six rabbits were randomly divided into 6 groups: SHAM, Control, Saline, DB, NA, DB+NA. All the animals, except for SHAM, were subjected to hemorrhage of 25% of the calculated blood volume. Control animals were replaced with their own blood. The other groups received NSS 3 times the volume withdrawn. The intravascular retention, hematocrit, diuresis, central venous pressure, mean arterial pressure, NGAL, dry-to-wet lung weight ratio (DTWR) and the lung and kidney histology were analyzed. RESULTS: Replacement with NSS and NA, DB or NA+DB did not produce differences in the intravascular retention. After hemorrhage, the animals presented a significant decrease in the MAP and CVP, which were maintained until volume replacement. Regarding NGAL, dry-to-wet-lung-weight ratio, lung and kidney histology, there were no statistical differences between the groups. CONCLUSION: The use of noradrenaline, dobutamine or their combination did not increase the intravascular retention of volume after normal saline infusion.