Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1055/a-1089-8342 http://hdl.handle.net/11449/196784 |
Resumo: | Bidens pilosa is an herb popularly used to treat inflammation, hemorrhoids, fever, and gastric ulcers with reported pharmacological activities and chemical composition that sustain its selection as a potential intestinal anti-inflammatory product. Based on this, we examined the effects of a B. pilosa fatty acid-standardized supercritical preparation on the intestinal inflammatory process induced by trinitrobenzenesulphonic acid in rats, using either preventative or curative treatments. We also investigated the safety of plant extract by acute and sub-chronic toxicological analysis. The intestinal anti-inflammatory activity was related to modulation of the immune response, increasing IL-10 production and reducing IL-1 beta , IL-6, and TNF- alpha level, the oxidative stress, and the MUC production in the inflamed colon. Optic, scanning, and transmission electron microscopy (TEM) analysis supported the beneficial effects promoted by B. pilosa , which were closely related to downregulation of heparanase, Hsp70, Mapk 3, and NF- kappa B signaling and with the presence of long-chain fatty acids in extract. Our data suggest that B. pilosa supercritical preparation is a chemically standardized preparation potentially useful as complementary intestinal anti-inflammatory agent to treat inflammatory bowel disease. |
id |
UNSP_9809cfe6f39b23b558360e8890b5719f |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/196784 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in RatsIBDBidens pilosaAsteraceaecytokinesmucinsoxidative stressimmune modulationBidens pilosa is an herb popularly used to treat inflammation, hemorrhoids, fever, and gastric ulcers with reported pharmacological activities and chemical composition that sustain its selection as a potential intestinal anti-inflammatory product. Based on this, we examined the effects of a B. pilosa fatty acid-standardized supercritical preparation on the intestinal inflammatory process induced by trinitrobenzenesulphonic acid in rats, using either preventative or curative treatments. We also investigated the safety of plant extract by acute and sub-chronic toxicological analysis. The intestinal anti-inflammatory activity was related to modulation of the immune response, increasing IL-10 production and reducing IL-1 beta , IL-6, and TNF- alpha level, the oxidative stress, and the MUC production in the inflamed colon. Optic, scanning, and transmission electron microscopy (TEM) analysis supported the beneficial effects promoted by B. pilosa , which were closely related to downregulation of heparanase, Hsp70, Mapk 3, and NF- kappa B signaling and with the presence of long-chain fatty acids in extract. Our data suggest that B. pilosa supercritical preparation is a chemically standardized preparation potentially useful as complementary intestinal anti-inflammatory agent to treat inflammatory bowel disease.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sao Paulo State Univ, Lab Phytomed Pharmacol & Biotechnol PhytoPharmaTe, Dept Pharmacol, UNESP,Inst Biosci, Rua Prof Dr Antonio Celso Wagner Zanin 250, BR-18618689 Botucatu, SP, BrazilSao Paulo State Univ, Lab Phytomed Pharmacol & Biotechnol PhytoPharmaTe, Dept Pharmacol, UNESP,Inst Biosci, Rua Prof Dr Antonio Celso Wagner Zanin 250, BR-18618689 Botucatu, SP, BrazilFAPESP: 15/15267-8FAPESP: 17/03959-8FAPESP: 11/50824-4Georg Thieme Verlag KgUniversidade Estadual Paulista (Unesp)Quaglio, Ana E. [UNESP]Cruz, Vinicius M. [UNESP]Almeida-Junior, Luiz D. [UNESP]Costa, Celso A. R. A. [UNESP]Di Stasi, Luiz C. [UNESP]2020-12-10T19:56:03Z2020-12-10T19:56:03Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article319-330http://dx.doi.org/10.1055/a-1089-8342Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 86, n. 5, p. 319-330, 2020.0032-0943http://hdl.handle.net/11449/19678410.1055/a-1089-8342WOS:000526569700003Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlanta Medicainfo:eu-repo/semantics/openAccess2021-10-23T10:02:18Zoai:repositorio.unesp.br:11449/196784Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T10:02:18Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats |
title |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats |
spellingShingle |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats Quaglio, Ana E. [UNESP] IBD Bidens pilosa Asteraceae cytokines mucins oxidative stress immune modulation |
title_short |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats |
title_full |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats |
title_fullStr |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats |
title_full_unstemmed |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats |
title_sort |
Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats |
author |
Quaglio, Ana E. [UNESP] |
author_facet |
Quaglio, Ana E. [UNESP] Cruz, Vinicius M. [UNESP] Almeida-Junior, Luiz D. [UNESP] Costa, Celso A. R. A. [UNESP] Di Stasi, Luiz C. [UNESP] |
author_role |
author |
author2 |
Cruz, Vinicius M. [UNESP] Almeida-Junior, Luiz D. [UNESP] Costa, Celso A. R. A. [UNESP] Di Stasi, Luiz C. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Quaglio, Ana E. [UNESP] Cruz, Vinicius M. [UNESP] Almeida-Junior, Luiz D. [UNESP] Costa, Celso A. R. A. [UNESP] Di Stasi, Luiz C. [UNESP] |
dc.subject.por.fl_str_mv |
IBD Bidens pilosa Asteraceae cytokines mucins oxidative stress immune modulation |
topic |
IBD Bidens pilosa Asteraceae cytokines mucins oxidative stress immune modulation |
description |
Bidens pilosa is an herb popularly used to treat inflammation, hemorrhoids, fever, and gastric ulcers with reported pharmacological activities and chemical composition that sustain its selection as a potential intestinal anti-inflammatory product. Based on this, we examined the effects of a B. pilosa fatty acid-standardized supercritical preparation on the intestinal inflammatory process induced by trinitrobenzenesulphonic acid in rats, using either preventative or curative treatments. We also investigated the safety of plant extract by acute and sub-chronic toxicological analysis. The intestinal anti-inflammatory activity was related to modulation of the immune response, increasing IL-10 production and reducing IL-1 beta , IL-6, and TNF- alpha level, the oxidative stress, and the MUC production in the inflamed colon. Optic, scanning, and transmission electron microscopy (TEM) analysis supported the beneficial effects promoted by B. pilosa , which were closely related to downregulation of heparanase, Hsp70, Mapk 3, and NF- kappa B signaling and with the presence of long-chain fatty acids in extract. Our data suggest that B. pilosa supercritical preparation is a chemically standardized preparation potentially useful as complementary intestinal anti-inflammatory agent to treat inflammatory bowel disease. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-10T19:56:03Z 2020-12-10T19:56:03Z 2020-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1055/a-1089-8342 Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 86, n. 5, p. 319-330, 2020. 0032-0943 http://hdl.handle.net/11449/196784 10.1055/a-1089-8342 WOS:000526569700003 |
url |
http://dx.doi.org/10.1055/a-1089-8342 http://hdl.handle.net/11449/196784 |
identifier_str_mv |
Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 86, n. 5, p. 319-330, 2020. 0032-0943 10.1055/a-1089-8342 WOS:000526569700003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Planta Medica |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
319-330 |
dc.publisher.none.fl_str_mv |
Georg Thieme Verlag Kg |
publisher.none.fl_str_mv |
Georg Thieme Verlag Kg |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964505057263616 |