Benign Pilomatricoma in a Shih-Tzu Dog

Detalhes bibliográficos
Autor(a) principal: Jorge, Manuela Amanda
Data de Publicação: 2023
Outros Autores: Charas dos Santos, Ivan Felismino [UNESP], Oliveira, Julia Viana de, Maciel de Mendonca, Maria Luiza, Sartori, Mariana, Moretti, Marcela Fernanda, Zacarias, Ademir, Zadra, Vivian Ferreira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.22456/1679-9216.126521
http://hdl.handle.net/11449/245242
Resumo: Background: Pilomatricomas are neoplasms of hair follicles, located in the hair bulb, and the incidence is uncommon in the clinical-surgical clinical routine of dogs and cats. It commonly affects adult animals, with no predisposition to sex or race, and is mainly located in the neck, back, and tail region. The diagnosis is made by histopathological examination, where cells are observed in which their nucleus does not stain with hematoxylin and eosin - empty nucleus. The present work aimed to report a case of benign pilomatricoma since it is a rare condition in dogs and cats and, consequently, there is little information in the literature. Case: A 6-year-old male Shih-Tzu dog, not submitted to surgical contraception, weighing 6.9 kg, was treated at the Veterinary School Hospital (HVE) of the North Parana State University (UENP), Bandeirantes, PR, Brazil, with a history of nodules in the tail region, lasting 6 months. On physical examination, no changes were identified in the patient's physiological parameters. However, the presence of neoformations in the distal and medial region of the tail, similar to a nail, adherent, non-ulcerated and non-alopecic, and absence of pruritus or self-mutilation were identified. Vaccination and deworming were updated. Hematological examination, serum biochemicals (urea, creatinine, alanine aminotransferase, alkaline phosphatase, and albumin), and abdominal ultrasound showed no changes. According to the clinical and laboratory signs, it was decided to perform an excisional biopsy, using a caudectomy, for subsequent histopathological examination. The specimens were fixed in 10% formaldehyde and sent for histopathological examination. Histological examination was compatible with benign pilomatricoma. Postoperatively, cephalexin, dipyrone, tramadol hydrochloride, and meloxicam were prescribed, surgical wound cleaning, and the use of an Elizabethan collar until the suture was removed. After 10 days of the surgical procedure, the patient was asked to remove the sutures, and no changes were identified regarding the physiological parameters and blood count. Discussion: Pilomatricomas are commonly benign neoplasms arising from the germ cells of the follicular matrix. They present dermal or subdermal forms, with several cystic structures which are surrounded by keratinocytes, similar to the matrix cells of an anagen hair follicle, more keratinized and firmer areas, corroborating the results of the present report. In the ultrasound examination, the presence of intra-abdominal metastases was not identified, which is consistent with the literature, since in this type of neoplasm it is not common to identify foci of intra-abdominal and thoracic metastases. In the present report, immunohistochemistry was not used, even though it is used to differentiate follicular neoplasms from pilomatricomas. However, histopathological examination is considered the best method for the definitive diagnosis of pilomatricomas in dogs. It was concluded that the surgical treatment through excisional biopsy, with safety margins of 2 cm, was effective as a therapeutic method in the case of benign pilomatricoma, and the definitive diagnosis must be made through histopathological examination.
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spelling Benign Pilomatricoma in a Shih-Tzu Dogsurgerydermatologyhair follicleneoplasiaBackground: Pilomatricomas are neoplasms of hair follicles, located in the hair bulb, and the incidence is uncommon in the clinical-surgical clinical routine of dogs and cats. It commonly affects adult animals, with no predisposition to sex or race, and is mainly located in the neck, back, and tail region. The diagnosis is made by histopathological examination, where cells are observed in which their nucleus does not stain with hematoxylin and eosin - empty nucleus. The present work aimed to report a case of benign pilomatricoma since it is a rare condition in dogs and cats and, consequently, there is little information in the literature. Case: A 6-year-old male Shih-Tzu dog, not submitted to surgical contraception, weighing 6.9 kg, was treated at the Veterinary School Hospital (HVE) of the North Parana State University (UENP), Bandeirantes, PR, Brazil, with a history of nodules in the tail region, lasting 6 months. On physical examination, no changes were identified in the patient's physiological parameters. However, the presence of neoformations in the distal and medial region of the tail, similar to a nail, adherent, non-ulcerated and non-alopecic, and absence of pruritus or self-mutilation were identified. Vaccination and deworming were updated. Hematological examination, serum biochemicals (urea, creatinine, alanine aminotransferase, alkaline phosphatase, and albumin), and abdominal ultrasound showed no changes. According to the clinical and laboratory signs, it was decided to perform an excisional biopsy, using a caudectomy, for subsequent histopathological examination. The specimens were fixed in 10% formaldehyde and sent for histopathological examination. Histological examination was compatible with benign pilomatricoma. Postoperatively, cephalexin, dipyrone, tramadol hydrochloride, and meloxicam were prescribed, surgical wound cleaning, and the use of an Elizabethan collar until the suture was removed. After 10 days of the surgical procedure, the patient was asked to remove the sutures, and no changes were identified regarding the physiological parameters and blood count. Discussion: Pilomatricomas are commonly benign neoplasms arising from the germ cells of the follicular matrix. They present dermal or subdermal forms, with several cystic structures which are surrounded by keratinocytes, similar to the matrix cells of an anagen hair follicle, more keratinized and firmer areas, corroborating the results of the present report. In the ultrasound examination, the presence of intra-abdominal metastases was not identified, which is consistent with the literature, since in this type of neoplasm it is not common to identify foci of intra-abdominal and thoracic metastases. In the present report, immunohistochemistry was not used, even though it is used to differentiate follicular neoplasms from pilomatricomas. However, histopathological examination is considered the best method for the definitive diagnosis of pilomatricomas in dogs. It was concluded that the surgical treatment through excisional biopsy, with safety margins of 2 cm, was effective as a therapeutic method in the case of benign pilomatricoma, and the definitive diagnosis must be made through histopathological examination.Univ Norte Parana UNOPAR, Curso Mestrado Saude & Prod Anim, Arapongas, Parana, BrazilUniv Fed Rondonia UNIR, Curso Med Vet, Rolim De Moura, RO, BrazilUniv Estadual Paulista UNESP, Fac Med Vet & Zootecnia FMVZ, Programa Posgrad Biotecnol Anim, Botucatu, SP, BrazilUniv Estadual Londrina UEL, Curso Mestrado Ciencia Anim, Londrina, PR, BrazilUniv Estadual Norte Parana UENP, Bandeirantes, PR, BrazilUniv Estadual Maringa UEM, Dept Med Vet, Umuarama, PR, BrazilUniv Estadual Paulista UNESP, Fac Med Vet & Zootecnia FMVZ, Programa Posgrad Biotecnol Anim, Botucatu, SP, BrazilUniv Fed Rio Grande Do SulUniv Norte Parana UNOPARUniv Fed Rondonia UNIRUniversidade Estadual Paulista (UNESP)Universidade Estadual de Londrina (UEL)Univ Estadual Norte Parana UENPUniversidade Estadual de Maringá (UEM)Jorge, Manuela AmandaCharas dos Santos, Ivan Felismino [UNESP]Oliveira, Julia Viana deMaciel de Mendonca, Maria LuizaSartori, MarianaMoretti, Marcela FernandaZacarias, AdemirZadra, Vivian Ferreira2023-07-29T11:49:21Z2023-07-29T11:49:21Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6http://dx.doi.org/10.22456/1679-9216.126521Acta Scientiae Veterinariae. Porto Alegre Rs: Univ Fed Rio Grande do Sul, v. 51, 6 p., 2023.1678-0345http://hdl.handle.net/11449/24524210.22456/1679-9216.126521WOS:000946274400009Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporActa Scientiae Veterinariaeinfo:eu-repo/semantics/openAccess2023-07-29T11:49:21Zoai:repositorio.unesp.br:11449/245242Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:03:00.108093Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Benign Pilomatricoma in a Shih-Tzu Dog
title Benign Pilomatricoma in a Shih-Tzu Dog
spellingShingle Benign Pilomatricoma in a Shih-Tzu Dog
Jorge, Manuela Amanda
surgery
dermatology
hair follicle
neoplasia
title_short Benign Pilomatricoma in a Shih-Tzu Dog
title_full Benign Pilomatricoma in a Shih-Tzu Dog
title_fullStr Benign Pilomatricoma in a Shih-Tzu Dog
title_full_unstemmed Benign Pilomatricoma in a Shih-Tzu Dog
title_sort Benign Pilomatricoma in a Shih-Tzu Dog
author Jorge, Manuela Amanda
author_facet Jorge, Manuela Amanda
Charas dos Santos, Ivan Felismino [UNESP]
Oliveira, Julia Viana de
Maciel de Mendonca, Maria Luiza
Sartori, Mariana
Moretti, Marcela Fernanda
Zacarias, Ademir
Zadra, Vivian Ferreira
author_role author
author2 Charas dos Santos, Ivan Felismino [UNESP]
Oliveira, Julia Viana de
Maciel de Mendonca, Maria Luiza
Sartori, Mariana
Moretti, Marcela Fernanda
Zacarias, Ademir
Zadra, Vivian Ferreira
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Norte Parana UNOPAR
Univ Fed Rondonia UNIR
Universidade Estadual Paulista (UNESP)
Universidade Estadual de Londrina (UEL)
Univ Estadual Norte Parana UENP
Universidade Estadual de Maringá (UEM)
dc.contributor.author.fl_str_mv Jorge, Manuela Amanda
Charas dos Santos, Ivan Felismino [UNESP]
Oliveira, Julia Viana de
Maciel de Mendonca, Maria Luiza
Sartori, Mariana
Moretti, Marcela Fernanda
Zacarias, Ademir
Zadra, Vivian Ferreira
dc.subject.por.fl_str_mv surgery
dermatology
hair follicle
neoplasia
topic surgery
dermatology
hair follicle
neoplasia
description Background: Pilomatricomas are neoplasms of hair follicles, located in the hair bulb, and the incidence is uncommon in the clinical-surgical clinical routine of dogs and cats. It commonly affects adult animals, with no predisposition to sex or race, and is mainly located in the neck, back, and tail region. The diagnosis is made by histopathological examination, where cells are observed in which their nucleus does not stain with hematoxylin and eosin - empty nucleus. The present work aimed to report a case of benign pilomatricoma since it is a rare condition in dogs and cats and, consequently, there is little information in the literature. Case: A 6-year-old male Shih-Tzu dog, not submitted to surgical contraception, weighing 6.9 kg, was treated at the Veterinary School Hospital (HVE) of the North Parana State University (UENP), Bandeirantes, PR, Brazil, with a history of nodules in the tail region, lasting 6 months. On physical examination, no changes were identified in the patient's physiological parameters. However, the presence of neoformations in the distal and medial region of the tail, similar to a nail, adherent, non-ulcerated and non-alopecic, and absence of pruritus or self-mutilation were identified. Vaccination and deworming were updated. Hematological examination, serum biochemicals (urea, creatinine, alanine aminotransferase, alkaline phosphatase, and albumin), and abdominal ultrasound showed no changes. According to the clinical and laboratory signs, it was decided to perform an excisional biopsy, using a caudectomy, for subsequent histopathological examination. The specimens were fixed in 10% formaldehyde and sent for histopathological examination. Histological examination was compatible with benign pilomatricoma. Postoperatively, cephalexin, dipyrone, tramadol hydrochloride, and meloxicam were prescribed, surgical wound cleaning, and the use of an Elizabethan collar until the suture was removed. After 10 days of the surgical procedure, the patient was asked to remove the sutures, and no changes were identified regarding the physiological parameters and blood count. Discussion: Pilomatricomas are commonly benign neoplasms arising from the germ cells of the follicular matrix. They present dermal or subdermal forms, with several cystic structures which are surrounded by keratinocytes, similar to the matrix cells of an anagen hair follicle, more keratinized and firmer areas, corroborating the results of the present report. In the ultrasound examination, the presence of intra-abdominal metastases was not identified, which is consistent with the literature, since in this type of neoplasm it is not common to identify foci of intra-abdominal and thoracic metastases. In the present report, immunohistochemistry was not used, even though it is used to differentiate follicular neoplasms from pilomatricomas. However, histopathological examination is considered the best method for the definitive diagnosis of pilomatricomas in dogs. It was concluded that the surgical treatment through excisional biopsy, with safety margins of 2 cm, was effective as a therapeutic method in the case of benign pilomatricoma, and the definitive diagnosis must be made through histopathological examination.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T11:49:21Z
2023-07-29T11:49:21Z
2023-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.22456/1679-9216.126521
Acta Scientiae Veterinariae. Porto Alegre Rs: Univ Fed Rio Grande do Sul, v. 51, 6 p., 2023.
1678-0345
http://hdl.handle.net/11449/245242
10.22456/1679-9216.126521
WOS:000946274400009
url http://dx.doi.org/10.22456/1679-9216.126521
http://hdl.handle.net/11449/245242
identifier_str_mv Acta Scientiae Veterinariae. Porto Alegre Rs: Univ Fed Rio Grande do Sul, v. 51, 6 p., 2023.
1678-0345
10.22456/1679-9216.126521
WOS:000946274400009
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language por
dc.relation.none.fl_str_mv Acta Scientiae Veterinariae
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dc.publisher.none.fl_str_mv Univ Fed Rio Grande Do Sul
publisher.none.fl_str_mv Univ Fed Rio Grande Do Sul
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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