Structural abnormalities of the thalamus in juvenile myoclonic epilepsy
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.yebeh.2011.05.018 http://hdl.handle.net/11449/12506 |
Resumo: | Studies have suggested that the thalamus is a key structure in the pathophysiology of juvenile myoclonic epilepsy. The objective of the present investigation was to examine the thalami of patients with juvenile myoclonic epilepsy using a combination of multiple structural neuroimaging modalities. The association between these techniques may reveal the mechanisms underlying juvenile myoclonic epilepsy and help to identify the neuroanatomical structures involved. Twenty-one patients with juvenile myoclonic epilepsy (13 women, mean age = 30 +/- 9 years) and a control group of 20 healthy individuals (10 women, mean age = 31 +/- 8 years) underwent MRI in a 2-T scanner. The volumetric three-dimensional sequence was used for structural investigation. Evaluation of the thalamus comprised voxel-based morphometry. automatic volumetry, and shape analysis. Comparisons were performed between patient and control groups. Voxel-based morphometry analysis identified areas of atrophy located in the anterior portion of the thalamus. Post hoc analysis of automatic volumetry did not reveal significant differences between the groups. Shape analysis disclosed differences between patients and controls in the anterior and inferior portions of the right thalamus and in the anterior portion of the left thalamus. The present investigation confirms that thalami of patients with juvenile myoclonic epilepsy are structurally abnormal with impairments located mainly in the anterior and inferior sections. (C) 2011 Elsevier B.V. All rights reserved. |
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Structural abnormalities of the thalamus in juvenile myoclonic epilepsyEpilepsyNeuroimagingJuvenile myoclonic epilepsyMagnetic resonanceVolumetryVoxel-based morphometryStudies have suggested that the thalamus is a key structure in the pathophysiology of juvenile myoclonic epilepsy. The objective of the present investigation was to examine the thalami of patients with juvenile myoclonic epilepsy using a combination of multiple structural neuroimaging modalities. The association between these techniques may reveal the mechanisms underlying juvenile myoclonic epilepsy and help to identify the neuroanatomical structures involved. Twenty-one patients with juvenile myoclonic epilepsy (13 women, mean age = 30 +/- 9 years) and a control group of 20 healthy individuals (10 women, mean age = 31 +/- 8 years) underwent MRI in a 2-T scanner. The volumetric three-dimensional sequence was used for structural investigation. Evaluation of the thalamus comprised voxel-based morphometry. automatic volumetry, and shape analysis. Comparisons were performed between patient and control groups. Voxel-based morphometry analysis identified areas of atrophy located in the anterior portion of the thalamus. Post hoc analysis of automatic volumetry did not reveal significant differences between the groups. Shape analysis disclosed differences between patients and controls in the anterior and inferior portions of the right thalamus and in the anterior portion of the left thalamus. The present investigation confirms that thalami of patients with juvenile myoclonic epilepsy are structurally abnormal with impairments located mainly in the anterior and inferior sections. (C) 2011 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Neurol Psiquiatria & Psicol, BR-18618970 Botucatu, SP, BrazilUniv Estadual Campinas, UNICAMP, Fac Med Sci, Dept Neurol, Campinas, SP, BrazilUniv Estadual Campinas, UNICAMP, Fac Med Sci, CInAPCe Program, Campinas, SP, BrazilUniv Estadual Campinas, UNICAMP, Fac Med Sci, Dept Med Genet, Campinas, SP, BrazilUniv Estadual Paulista, UNESP, Fac Med Botucatu, Dept Neurol Psiquiatria & Psicol, BR-18618970 Botucatu, SP, BrazilAcademic Press Inc. Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Mory, Susana BarretoBetting, Luiz Eduardo Gomes Garcia [UNESP]Fernandes, Paula T.Lopes-Cendes, IsciaGuerreiro, Marilisa M.Guerreiro, Carlos A. M.Cendes, FernandoLi, Li M.2014-05-20T13:36:19Z2014-05-20T13:36:19Z2011-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article407-411application/pdfhttp://dx.doi.org/10.1016/j.yebeh.2011.05.018Epilepsy & Behavior. San Diego: Academic Press Inc. Elsevier B.V., v. 21, n. 4, p. 407-411, 2011.1525-5050http://hdl.handle.net/11449/1250610.1016/j.yebeh.2011.05.018WOS:000294104900014WOS000294104900014.pdf5929929597248132Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEpilepsy & Behavior2.6001,131info:eu-repo/semantics/openAccess2024-08-16T15:45:41Zoai:repositorio.unesp.br:11449/12506Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:45:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Structural abnormalities of the thalamus in juvenile myoclonic epilepsy |
title |
Structural abnormalities of the thalamus in juvenile myoclonic epilepsy |
spellingShingle |
Structural abnormalities of the thalamus in juvenile myoclonic epilepsy Mory, Susana Barreto Epilepsy Neuroimaging Juvenile myoclonic epilepsy Magnetic resonance Volumetry Voxel-based morphometry |
title_short |
Structural abnormalities of the thalamus in juvenile myoclonic epilepsy |
title_full |
Structural abnormalities of the thalamus in juvenile myoclonic epilepsy |
title_fullStr |
Structural abnormalities of the thalamus in juvenile myoclonic epilepsy |
title_full_unstemmed |
Structural abnormalities of the thalamus in juvenile myoclonic epilepsy |
title_sort |
Structural abnormalities of the thalamus in juvenile myoclonic epilepsy |
author |
Mory, Susana Barreto |
author_facet |
Mory, Susana Barreto Betting, Luiz Eduardo Gomes Garcia [UNESP] Fernandes, Paula T. Lopes-Cendes, Iscia Guerreiro, Marilisa M. Guerreiro, Carlos A. M. Cendes, Fernando Li, Li M. |
author_role |
author |
author2 |
Betting, Luiz Eduardo Gomes Garcia [UNESP] Fernandes, Paula T. Lopes-Cendes, Iscia Guerreiro, Marilisa M. Guerreiro, Carlos A. M. Cendes, Fernando Li, Li M. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Mory, Susana Barreto Betting, Luiz Eduardo Gomes Garcia [UNESP] Fernandes, Paula T. Lopes-Cendes, Iscia Guerreiro, Marilisa M. Guerreiro, Carlos A. M. Cendes, Fernando Li, Li M. |
dc.subject.por.fl_str_mv |
Epilepsy Neuroimaging Juvenile myoclonic epilepsy Magnetic resonance Volumetry Voxel-based morphometry |
topic |
Epilepsy Neuroimaging Juvenile myoclonic epilepsy Magnetic resonance Volumetry Voxel-based morphometry |
description |
Studies have suggested that the thalamus is a key structure in the pathophysiology of juvenile myoclonic epilepsy. The objective of the present investigation was to examine the thalami of patients with juvenile myoclonic epilepsy using a combination of multiple structural neuroimaging modalities. The association between these techniques may reveal the mechanisms underlying juvenile myoclonic epilepsy and help to identify the neuroanatomical structures involved. Twenty-one patients with juvenile myoclonic epilepsy (13 women, mean age = 30 +/- 9 years) and a control group of 20 healthy individuals (10 women, mean age = 31 +/- 8 years) underwent MRI in a 2-T scanner. The volumetric three-dimensional sequence was used for structural investigation. Evaluation of the thalamus comprised voxel-based morphometry. automatic volumetry, and shape analysis. Comparisons were performed between patient and control groups. Voxel-based morphometry analysis identified areas of atrophy located in the anterior portion of the thalamus. Post hoc analysis of automatic volumetry did not reveal significant differences between the groups. Shape analysis disclosed differences between patients and controls in the anterior and inferior portions of the right thalamus and in the anterior portion of the left thalamus. The present investigation confirms that thalami of patients with juvenile myoclonic epilepsy are structurally abnormal with impairments located mainly in the anterior and inferior sections. (C) 2011 Elsevier B.V. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-08-01 2014-05-20T13:36:19Z 2014-05-20T13:36:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.yebeh.2011.05.018 Epilepsy & Behavior. San Diego: Academic Press Inc. Elsevier B.V., v. 21, n. 4, p. 407-411, 2011. 1525-5050 http://hdl.handle.net/11449/12506 10.1016/j.yebeh.2011.05.018 WOS:000294104900014 WOS000294104900014.pdf 5929929597248132 |
url |
http://dx.doi.org/10.1016/j.yebeh.2011.05.018 http://hdl.handle.net/11449/12506 |
identifier_str_mv |
Epilepsy & Behavior. San Diego: Academic Press Inc. Elsevier B.V., v. 21, n. 4, p. 407-411, 2011. 1525-5050 10.1016/j.yebeh.2011.05.018 WOS:000294104900014 WOS000294104900014.pdf 5929929597248132 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Epilepsy & Behavior 2.600 1,131 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
407-411 application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press Inc. Elsevier B.V. |
publisher.none.fl_str_mv |
Academic Press Inc. Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128142256111616 |