Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/aor.14401 http://hdl.handle.net/11449/247685 |
Resumo: | Background: Treatment for severe acute kidney injury (AKI) typically involves the use of acute kidney replacement therapy (AKRT) to prevent or reverse complications. Methodology: We aimed to determine the prevalence of successful discontinuation of AKRT and its predictive factors. A retrospective cohort study was performed with 316 patients hospitalized at a public Brazilian university hospital between January 2011 and June 2020. Results: Success and hospital discharge were achieved for most patients (85% and 74%, respectively). Multivariable logistic regression analysis showed that C-reactive protein (CRP), urine output, and need mechanical ventilation at the time of interruption were variable associated with discontinuation success (OR 0.969, CI 0.918–0.998, p = 0.031; OR 1.008, CI 1.001–1.012, p = 0.041 and OR 0.919, CI 0.901–0.991, p = 0.030; respectively), while the absence of comorbidities such as chronic kidney disease (OR 0.234, CI 0.08–0.683, p = 0.008), cardiovascular disease (OR 0.353, CI 0.134–0.929, p = 0.035) and hypertension (OR 0.278, CI 0.003–0.882, p = 0.009), as well as pH values at the time of AKRT indication (OR 1.273, CI 1.003–1.882, p = 0.041), mechanical ventilation at the time of interruption (OR 0.19, CI 0.19–0.954, p = 0.038) and successful discontinuation (OR 8.657, CI 3.135–23.906, p < 0.001) were identified as variables associated with hospital discharge. Conclusion: These results show that clinical conditions such as comorbidities, urine output, and mechanical ventilation, and laboratory variables such as pH and CRP are factors associated with hospital discharge and AKRT discontinuation success, requiring larger studies for confirmation. |
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Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort studyacute kidney injurydiscontinuationpredictive factorsrenal replacement therapysuccessBackground: Treatment for severe acute kidney injury (AKI) typically involves the use of acute kidney replacement therapy (AKRT) to prevent or reverse complications. Methodology: We aimed to determine the prevalence of successful discontinuation of AKRT and its predictive factors. A retrospective cohort study was performed with 316 patients hospitalized at a public Brazilian university hospital between January 2011 and June 2020. Results: Success and hospital discharge were achieved for most patients (85% and 74%, respectively). Multivariable logistic regression analysis showed that C-reactive protein (CRP), urine output, and need mechanical ventilation at the time of interruption were variable associated with discontinuation success (OR 0.969, CI 0.918–0.998, p = 0.031; OR 1.008, CI 1.001–1.012, p = 0.041 and OR 0.919, CI 0.901–0.991, p = 0.030; respectively), while the absence of comorbidities such as chronic kidney disease (OR 0.234, CI 0.08–0.683, p = 0.008), cardiovascular disease (OR 0.353, CI 0.134–0.929, p = 0.035) and hypertension (OR 0.278, CI 0.003–0.882, p = 0.009), as well as pH values at the time of AKRT indication (OR 1.273, CI 1.003–1.882, p = 0.041), mechanical ventilation at the time of interruption (OR 0.19, CI 0.19–0.954, p = 0.038) and successful discontinuation (OR 8.657, CI 3.135–23.906, p < 0.001) were identified as variables associated with hospital discharge. Conclusion: These results show that clinical conditions such as comorbidities, urine output, and mechanical ventilation, and laboratory variables such as pH and CRP are factors associated with hospital discharge and AKRT discontinuation success, requiring larger studies for confirmation.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Discente de Medicina da Faculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESPDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESPDiscente de Medicina da Faculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESPDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESPCNPq: 12095220203.Universidade Estadual Paulista (UNESP)Ohara, Cristine Naomi [UNESP]Suarez, Maria Irma [UNESP]Kitawara, Koody Hassemi [UNESP]Zamoner, Welder [UNESP]Balbi, André Luis [UNESP]Ponce, Daniela [UNESP]2023-07-29T13:23:05Z2023-07-29T13:23:05Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article187-197http://dx.doi.org/10.1111/aor.14401Artificial Organs, v. 47, n. 1, p. 187-197, 2023.1525-15940160-564Xhttp://hdl.handle.net/11449/24768510.1111/aor.144012-s2.0-85138998112Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArtificial Organsinfo:eu-repo/semantics/openAccess2024-08-14T17:23:00Zoai:repositorio.unesp.br:11449/247685Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study |
title |
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study |
spellingShingle |
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study Ohara, Cristine Naomi [UNESP] acute kidney injury discontinuation predictive factors renal replacement therapy success |
title_short |
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study |
title_full |
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study |
title_fullStr |
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study |
title_full_unstemmed |
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study |
title_sort |
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study |
author |
Ohara, Cristine Naomi [UNESP] |
author_facet |
Ohara, Cristine Naomi [UNESP] Suarez, Maria Irma [UNESP] Kitawara, Koody Hassemi [UNESP] Zamoner, Welder [UNESP] Balbi, André Luis [UNESP] Ponce, Daniela [UNESP] |
author_role |
author |
author2 |
Suarez, Maria Irma [UNESP] Kitawara, Koody Hassemi [UNESP] Zamoner, Welder [UNESP] Balbi, André Luis [UNESP] Ponce, Daniela [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Ohara, Cristine Naomi [UNESP] Suarez, Maria Irma [UNESP] Kitawara, Koody Hassemi [UNESP] Zamoner, Welder [UNESP] Balbi, André Luis [UNESP] Ponce, Daniela [UNESP] |
dc.subject.por.fl_str_mv |
acute kidney injury discontinuation predictive factors renal replacement therapy success |
topic |
acute kidney injury discontinuation predictive factors renal replacement therapy success |
description |
Background: Treatment for severe acute kidney injury (AKI) typically involves the use of acute kidney replacement therapy (AKRT) to prevent or reverse complications. Methodology: We aimed to determine the prevalence of successful discontinuation of AKRT and its predictive factors. A retrospective cohort study was performed with 316 patients hospitalized at a public Brazilian university hospital between January 2011 and June 2020. Results: Success and hospital discharge were achieved for most patients (85% and 74%, respectively). Multivariable logistic regression analysis showed that C-reactive protein (CRP), urine output, and need mechanical ventilation at the time of interruption were variable associated with discontinuation success (OR 0.969, CI 0.918–0.998, p = 0.031; OR 1.008, CI 1.001–1.012, p = 0.041 and OR 0.919, CI 0.901–0.991, p = 0.030; respectively), while the absence of comorbidities such as chronic kidney disease (OR 0.234, CI 0.08–0.683, p = 0.008), cardiovascular disease (OR 0.353, CI 0.134–0.929, p = 0.035) and hypertension (OR 0.278, CI 0.003–0.882, p = 0.009), as well as pH values at the time of AKRT indication (OR 1.273, CI 1.003–1.882, p = 0.041), mechanical ventilation at the time of interruption (OR 0.19, CI 0.19–0.954, p = 0.038) and successful discontinuation (OR 8.657, CI 3.135–23.906, p < 0.001) were identified as variables associated with hospital discharge. Conclusion: These results show that clinical conditions such as comorbidities, urine output, and mechanical ventilation, and laboratory variables such as pH and CRP are factors associated with hospital discharge and AKRT discontinuation success, requiring larger studies for confirmation. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:23:05Z 2023-07-29T13:23:05Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/aor.14401 Artificial Organs, v. 47, n. 1, p. 187-197, 2023. 1525-1594 0160-564X http://hdl.handle.net/11449/247685 10.1111/aor.14401 2-s2.0-85138998112 |
url |
http://dx.doi.org/10.1111/aor.14401 http://hdl.handle.net/11449/247685 |
identifier_str_mv |
Artificial Organs, v. 47, n. 1, p. 187-197, 2023. 1525-1594 0160-564X 10.1111/aor.14401 2-s2.0-85138998112 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Artificial Organs |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
187-197 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128147462291456 |